DOI stringlengths 28 49 | Title stringlengths 19 460 | Authors stringlengths 12 2.65k | Abstract stringlengths 279 7.2k | Journal stringlengths 3 82 | Date stringclasses 49
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('LID', '10.1016/j.ccell.2025.02.024') | PAI-1-driven SFRP2(high) cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy. | Zhang, Yan-Pei, Guo, Ze-Qin, Cai, Xiao-Ting, Rong, Zi-Xuan, Fang, Yuan, Chen, Jia-Qi, Zhuang, Kui-Mao, Ruan, Min-Jie, Ma, Si-Cong, Lin, Le-Yi, Han, Duan-Duan, Li, Yang-Si, Wang, Yuan-Yuan, Wang, Jian, Cao, Chuan-Hui, Tang, Xin-Ran, Xie, Qian-Kun, Chen, Yue, Lin, Yan, Tan, Jia-Le, Yu, Zi-Hang, Wu, Ze-Nan, Wei, Wei, Zhen... | The abscopal effect of radioimmunotherapy, wherein tumor shrinkage occurs beyond the irradiated field, is therapeutically promising but clinically rare. The mechanisms underlying this effect remain elusive. Here, in vivo genome-wide CRISPR screening identifies SFRP2 as a potential stromal regulator of the ... | Cancer cell | 12/03/2025 |
('LID', '10.1038/s41590-025-02104-y') | Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation. | Feng, Xiaogang, Andersson, Tilde, Flüchter, Pascal, Gschwend, Julia, Berest, Ivan, Muff, Julian L, Lechner, Antonie, Gondrand, Aurelia, Westermann, Patrick, Brander, Nina, Carchidi, Daniele, De Tenorio, Jeshua C, Pan, Tianlang, Boehm, Ulrich, Klose, Christoph S N, Artis, David, Messner, Christoph B, Leinders-Zufall, Tr... | The tuft cell-group 2 innate lymphoid cell (ILC2) circuit orchestrates rapid type 2 responses upon detecting microbially derived succinate and luminal helminths. Our findings delineate key mechanistic steps involving IP3R2 engagement and Ca(2+) flux, governing interleukin-25 (IL-25) production by tuft cells... | Nature immunology | 12/03/2025 |
('LID', '10.1126/science.adm9805') | Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling. | Koundouros, Nikos, Nagiec, Michal J, Bullen, Nayah, Noch, Evan K, Burgos-Barragan, Guillermo, Li, Zhongchi, He, Long, Cho, Sungyun, Parang, Bobak, Leone, Dominique, Andreopoulou, Eleni, Blenis, John | Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrient signaling mechanism involving fatty acid-binding protein 5 (FABP5) and mechanistic target of rapamycin com... | Science (New York, N.Y.) | 14/03/2025 |
('LID', '10.5546/aap.2020.eng.433') | Scientific paper management. How do articles get published in medical journals? | Serra, María E | The life-cycle of a manuscript from writing to publication is not usually taught during health care professionals' training. This article reviews the process that goes from from the authors' decision to communicate to its eventual publication, detailing practical aspects to be considered in each step. The r... | Archivos argentinos de pediatria | 00/12/2020 |
('LID', '10.1053/j.gastro.2025.01.252') | Mucosal macrophages govern intestinal regeneration in response to injury. | Moraitis, Ilias, Taelman, Jasin, Arozamena, Borja, Mularoni, Loris, Wienskowska, Olga, Sanjuan Garriga, Xavier, Arregui, Laura, Stefanovic, Milica, Modolell Farré, Ignasi, Guedea, Ferran, Diaz, Mònica, Guiu, Jordi | BACKGROUND & AIMS: Cancer patients treated with radiotherapy in the abdominal and pelvic cavity develop radiation-induced enteritis, a condition that impairs their quality of life. Radiation injury depletes proliferative intestinal stem cells (ISCs); in response to this, the epithelium activates a regenerat... | Gastroenterology | 03/03/2025 |
('LID', '10.1186/s40359-023-01477-9') | The development of the fear of earthquake scale: validity and reliability study in Türkiye after the 2023 earthquake. | Sarı, Tuğba, Taşdelen-Karçkay, Arzu, Tarcan, Şule | BACKGROUND: In 2023, Türkiye experienced a significant earthquake disaster that profoundly impacted 11 provinces. The enduring consequences of these earthquakes on daily life triggered widespread fears and anxieties in society, leading to scholarly investigations in this field. OBJECTIVE: The primary object... | BMC psychology | 07/12/2023 |
('LID', '10.1126/science.ado4188') | Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. | Lin, Hui, Ma, Chuanshun, Cai, Kui, Guo, Lulu, Wang, Xuemei, Lv, Lin, Zhang, Chao, Lin, Jun, Zhang, Daolai, Ye, Chuan, Wang, Tengwei, Huang, Shenming, Han, Jifei, Zhang, Zihao, Gao, Junyan, Zhang, Mingxiang, Pu, Zhao, Li, Fengyang, Guo, Yongyuan, Zhou, Xiaojun, Qin, Chengxue, Yi, Fan, Yu, Xiao, Kong, Wei, Jiang, Changta... | Ceramides play a central role in human health and disease, yet their role as systemic signaling molecules remain poorly understood. In this work, we identify FPR2 as a membrane receptor that specifically binds long-chain ceramides (C14-C20). In brown and beige adipocytes, C16:0 ceramide binding to FPR2 inhi... | Science (New York, N.Y.) | 13/03/2025 |
('LID', '10.1038/s41586-025-08668-x') | Spatial immune scoring system predicts hepatocellular carcinoma recurrence. | Jia, Gengjie, He, Peiqi, Dai, Tianli, Goh, Denise, Wang, Jiabei, Sun, Mengyuan, Wee, Felicia, Li, Fuling, Lim, Jeffrey Chun Tatt, Hao, Shuxia, Liu, Yao, Lim, Tony Kiat Hon, Ngo, Nye-Thane, Tao, Qingping, Wang, Wei, Umar, Ahitsham, Nashan, Björn, Zhang, Yongchang, Ding, Chen, Yeong, Joe, Liu, Lianxin, Sun, Cheng | Given the high recurrence rates of hepatocellular carcinoma (HCC) post-resection(1-3), improved early identification of patients at high risk for post-resection recurrence would help to improve patient outcomes and prioritize healthcare resources(4-6). Here we observed a spatial and HCC recurrence-assoc... | Nature | 12/03/2025 |
('LID', '10.1021/ja503015f') | Thieno-pyrrole-fused 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-fullerene dyads: utilization of near-infrared sensitizers for ultrafast charge separation in donor-acceptor systems. | Bandi, Venugopal, Das, Sushanta K, Awuah, Samuel G, You, Youngjae, D'Souza, Francis | Donor-acceptor dyads featuring near-IR sensitizers derived from thieno-pyrrole-fused BODIPY (abbreviated as SBDPiR) and fullerene, C60 have been newly synthesized and characterized. Occurrence of ultrafast photoinduced electron transfer (PET) leading to the formation of charge-separated state in these d... | Journal of the American Chemical Society | 28/05/2014 |
('LID', '10.1186/s12883-025-04122-7') | Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period. | López-Medina, Diana Carolina, Arboleda-Ramírez, Alejandra, Ríos-Díaz, Sara, Zambrano-Cruz, Renato, Arboleda-Jaramillo, Andrés, Betancur-Henao, Cristian, Henao-Pérez, Marcela | INTRODUCTION: Migraine is a highly prevalent and disabling condition, not only due to its painful symptoms but also because of its significant impact on mental health and cognitive functioning, leading to a considerable deterioration in quality of life. This study aimed to evaluate the cognitive profile, me... | BMC neurology | 14/03/2025 |
('LID', '10.1038/s41392-025-02170-6') | Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer. | Ma, Sheng, Wang, Zixian, Xiong, Zezhong, Ge, Yue, Xu, Meng-Yao, Zhang, Junbiao, Peng, Yuzheng, Zhang, Qin, Sun, Jiaxue, Xi, Zirui, Peng, Hao, Xu, Wenjie, Wang, Yanan, Li, Le, Zhang, Chunyu, Chao, Zheng, Wang, Baojun, Gao, Xu, Zhang, Xu, Wei, Gong-Hong, Wang, Zhihua | Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we performed integrated chromatin accessibility and transcriptomic anal... | Signal transduction and targeted therapy | 14/03/2025 |
('LID', '10.1016/S0140-6736(25)00263-6') | A multifaceted intervention to improve diagnosis and early management of hospitalised patients with suspected acute brain infections in Brazil, India, and Malawi: an international multicentre intervention study. | Singh, Bhagteshwar, Lipunga, Gareth D, Thangavelu, Premkumar, Dhar, Shalley, Ferreira Cronemberger, Lorena, Abhilash, Kundavaram Paul Prabhakar, Abraham, Asha Mary, de Brito, Carlos Alexandre Antunes, Brito Ferreira, Maria Lúcia, Chandrashekar, Nagarathna, Duarte, Rui, Fajardo Modol, Anna, Ghale, Ben Chirag, Kang, Gaga... | BACKGROUND: Brain infections pose substantial challenges in diagnosis and management and carry high mortality and morbidity, especially in low-income and middle-income countries. We aimed to improve the diagnosis and early management of patients admitted to hospital (adults aged 16 years and older and child... | Lancet (London, England) | 10/03/2025 |
('LID', '10.1016/j.neuron.2025.02.014') | Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum. | Ali, Muhammad, Timsina, Jigyasha, Western, Daniel, Liu, Menghan, Beric, Aleksandra, Budde, John, Do, Anh, Heo, Gyujin, Wang, Lihua, Gentsch, Jen, Schindler, Suzanne E, Morris, John C, Holtzman, David M, Ruiz, Agustin, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Rutledge, Jarod, Oh, Hamilton, Wilson, Edward N, Guen,... | Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a thr... | Neuron | 12/03/2025 |
('LID', '10.1016/j.cell.2025.02.012') | Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits. | Binan, Loϊc, Jiang, Aiping, Danquah, Serwah A, Valakh, Vera, Simonton, Brooke, Bezney, Jon, Manguso, Robert T, Yates, Kathleen B, Nehme, Ralda, Cleary, Brian, Farhi, Samouil L | Pooled optical screens have enabled the study of cellular interactions, morphology, or dynamics at massive scale, but they have not yet leveraged the power of highly plexed single-cell resolved transcriptomic readouts to inform molecular pathways. Here, we present a combination of imaging spatial transc... | Cell | 10/03/2025 |
('LID', '10.1016/j.intimp.2025.114388') | Indole-3-propionic acid alleviates DSS-induced colitis in mice through macrophage glycolipid metabolism. | Li, Jiahong, Zou, Peicen, Xiao, Ruiqi, Wang, Yajuan | Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease for which current therapeutic approaches still face many dilemmas, and targeting macrophage polarization and metabolism for the treatment of this disease is a potentially effective strategy. The gut microbial metabolite indole-3-propi... | International immunopharmacology | 13/03/2025 |
('LID', '10.1016/j.foodchem.2018.04.067') | Transglutaminase mediated microencapsulation of sea buckthorn supercritical CO(2) extract in whey protein isolate and valorization in highly value added food products. | Mihalcea, Liliana, Turturică, Mihaela, Barbu, Vasilica, Ioniţă, Elena, Pătraşcu, Livia, Cotârleţ, Mihaela, Dumitraşcu, Loredana, Aprodu, Iuliana, Râpeanu, Gabriela, Stănciuc, Nicoleta | Sea buckthorn carotenoids extracted using CO(2) supercritical fluids method were encapsulated within whey proteins isolate by transglutaminase (TG) mediated crosslinking reaction, coacervation and freeze drying. The encapsulation efficiency was 36.23 ± 1.58%, with β-carotene the major carotenoid present in ... | Food chemistry | 01/10/2018 |
('LID', '10.1016/S0140-6736(24)02722-3') | Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China. | Xiong, Anwen, Wang, Lei, Chen, Jianhua, Wu, Lin, Liu, Baogang, Yao, Jun, Zhong, Hua, Li, Jie, Cheng, Ying, Sun, Yulan, Ge, Hui, Yao, Jifang, Shi, Qin, Zhou, Ming, Chen, Bolin, Han, Zhengxiang, Wang, Jinliang, Bu, Qing, Zhao, Yanqiu, Chen, Junqiang, Nie, Ligong, Li, Gaofeng, Li, Xingya, Yu, Xinmin, Ji, Yinghua, Sun, Daq... | BACKGROUND: Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outcomes for patients with advanced non-small cell lung cancer in early-phase studies. We compared the efficacy and safety of ivonescimab with pembroli... | Lancet (London, England) | 08/03/2025 |
('LID', '10.1002/anie.201601989') | Positioning a Carbon-Fluorine Bond over the π Cloud of an Aromatic Ring: A Different Type of Arene Activation. | Holl, Maxwell Gargiulo, Struble, Mark D, Singal, Prakhar, Siegler, Maxime A, Lectka, Thomas | It is known that the fluoro group has only a small effect on the rates of electrophilic aromatic substitutions. Imagine instead a carbon-fluorine (C-F) bond positioned tightly over the π cloud of an aryl ring-such an orthogonal, noncovalent arrangement could instead stabilize a positively charged arene ... | Angewandte Chemie (International ed. in English) | 11/07/2016 |
('LID', '10.1038/s41591-025-03600-2') | A B7H3-targeting antibody-drug conjugate in advanced solid tumors: a phase 1/1b trial. | Ma, Yuxiang, Yang, Yunpeng, Huang, Yan, Fang, Wenfeng, Xue, Jinhui, Meng, Xiangjiao, Fan, Yun, Fu, Siqing, Wu, Lin, Zheng, Yulong, Liu, Jian, Liu, Zhihua, Zhuang, Wu, Rosen, Seth, Qu, Song, Li, Bihui, Li, Mingjun, Zhao, Yanqiu, Yang, Shujun, Ji, Yinghua, Sommerhalder, David, Luo, Suxia, Yang, Kunyu, Li, Jingao, Lv, Don... | Antibody-drug conjugates (ADCs) have emerged as a transformative modality in the treatment of solid tumors. YL201, a novel B7H3-targeting ADC, leverages a tumor microenvironment activable linker-payload platform, coupled with a novel topoisomerase 1 inhibitor via a protease-cleavable linker. Here we report ... | Nature medicine | 13/03/2025 |
('LID', '10.1126/science.adv3451') | Cryo-EM reveals mechanisms of natural RNA multivalency. | Wang, Liu, Xie, Jiahao, Gong, Tao, Wu, Hao, Tu, Yifan, Peng, Xin, Shang, Sitong, Jia, Xinyu, Ma, Haiyun, Zou, Jian, Xu, Sheng, Zheng, Xin, Zhang, Dong, Liu, Yang, Zhang, Chong, Luo, Yongbo, Huang, Zirui, Shao, Bin, Ying, Binwu, Cheng, Yu, Guo, Yingqiang, Lai, Ying, Huang, Dingming, Liu, Jianquan, Wei, Yuquan, Sun, Siqi... | Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical to understanding various cellular processes. However, RNA quaternary structures have been rarely reported. Comparative genomics analysis has identified RNA families containing hundreds of sequences that adopt ... | Science (New York, N.Y.) | 13/03/2025 |
('LID', '10.1016/j.ccell.2025.02.009') | Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis. | Chang, Jiang, Lu, Junting, Liu, Qingyi, Xiang, Tao, Zhang, Shaosen, Yi, Yonglin, Li, Dongxu, Liu, Tianyuan, Liu, Zeyuan, Chen, Xinjie, Dong, Zhenghao, Li, Cainan, Yi, HanZhang, Yu, Siqi, Huang, Luwei, Qu, Fangfei, Wang, Mengdi, Wang, Dehe, Dong, Hao, Cheng, Guoyu, Zhu, Liang, Li, Jiachen, Li, Chenying, Wu, Pujie, Xie, ... | Cancer development involves the co-evolution of cancer cells and their surrounding microenvironment, yet the dynamics of this interaction within the physical architecture remains poorly understood. Here, we present a spatial transcriptomic map at single-cell resolution, encompassing 127 multi-stage fields ... | Cancer cell | 10/03/2025 |
('LID', '10.1158/0008-5472.CAN-24-1879') | Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals. | Lawson-Michod, Katherine A, Marks, Jeffrey R, Collin, Lindsay J, Nix, David A, Davidson, Natalie R, Huff, Chad D, Yu, Yao, Atkinson, Aaron, Johnson, Courtney E, Salas, Lucas A, Peres, Lauren C, Greene, Casey S, Schildkraut, Joellen M, Doherty, Jennifer A | Black individuals experience worse survival after a diagnosis of high-grade serous ovarian carcinoma (HGSC) than White individuals and are underrepresented in ovarian cancer research. To date, the understanding of the molecular and genomic heterogeneity of HGSC is based primarily on the evaluation of tumors... | Cancer research | 10/03/2025 |
('LID', '10.1016/S2468-1253(24)00390-X') | The intestinal barrier: a pivotal role in health, inflammation, and cancer. | Neurath, Markus F, Artis, David, Becker, Christoph | The intestinal barrier serves as a boundary between the mucosal immune system in the lamina propria and the external environment of the intestinal lumen, which contains a diverse array of microorganisms and ingested environmental factors, including pathogens, food antigens, toxins, and other foreign substan... | The lancet. Gastroenterology & hepatology | 11/03/2025 |
('LID', '10.1016/j.ccell.2025.02.026') | Distinct CD8(+) T cell dynamics associate with response to neoadjuvant cancer immunotherapies. | Li, Housaiyin, Zandberg, Dan P, Kulkarni, Aditi, Chiosea, Simion I, Santos, Patricia M, Isett, Brian R, Joy, Marion, Sica, Gabriel L, Contrera, Kevin J, Tatsuoka, Curtis M, Brand, Matthias, Duvvuri, Umamaheswar, Kim, Seungwon, Kubik, Mark, Sridharan, Shaum, Tu, Fei, Chen, Jie, Bruno, Tullia C, Vignali, Dario A A, Cillo... | We leverage a clinical trial (NCT04080804) that compared neoadjuvant anti-PD-1, anti-PD-1+CTLA-4, and anti-PD-1+LAG-3 therapies in head and neck squamous cell carcinoma patients. Combination therapies promote higher pathologic response rates versus monotherapy, and major pathologic response is associated wi... | Cancer cell | 12/03/2025 |
('LID', '10.1038/s41593-025-01914-5') | Endothelial TDP-43 depletion disrupts core blood-brain barrier pathways in neurodegeneration. | Omar, Omar M F, Kimble, Amy L, Cheemala, Ashok, Tyburski, Jordan D, Pandey, Swati, Wu, Qian, Reese, Bo, Jellison, Evan R, Hao, Bing, Li, Yunfeng, Yan, Riqiang, Murphy, Patrick A | Endothelial cells (ECs) help maintain the blood-brain barrier but deteriorate in many neurodegenerative disorders. Here we show, using a specialized method to isolate EC and microglial nuclei from postmortem human cortex (92 donors, 50 male and 42 female, aged 20-98 years), that intranuclear cellular indexi... | Nature neuroscience | 14/03/2025 |
('LID', '10.1016/j.freeradbiomed.2025.03.014') | Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation. | Cao, Min-Min, Guo, Zhe, Wang, Jun, Ma, Hui-Yong, Qin, Xiao-Yan, Hu, Yang, Lan, Rongfeng | Astragalin (AST) is a flavonoid glycoside commonly found in edible plants and medicinal herbs with a variety of therapeutic effects. This study aimed to investigate whether AST protects the integrity of the blood-brain barrier (BBB) and inhibits neuroinflammation, thereby alleviating depressive-like behavio... | Free radical biology & medicine | 13/03/2025 |
('LID', '10.1001/jamanetworkopen.2025.0648') | Mizoribine or Cyclophosphamide for Lupus Nephritis: A Randomized Clinical Trial. | Dong, Zheyi, Luo, Ping, Sun, Shiren, Ni, Zhaohui, He, Yani, Huang, Xiangyang, Liu, Zhangsuo, Wu, Zhenbiao, Zhang, Xinzhou, Liao, Yunhua, Zhao, Jianhong, Lin, Hongli, Zhang, Xiao, Fu, Rongguo, Ding, Guohua, Xu, Yan, Wang, Lihua, Xiao, Yuefei, Shi, Shumei, Zuo, Xiaoxia, Li, Zhanguo, Qiao, Li, Wang, Rong, Li, Wenge, Wan, ... | IMPORTANCE: Lupus nephritis is typically treated with intravenous cyclophosphamide, which is associated with serious adverse effects. Oral mizoribine may be an alternative for induction therapy of lupus nephritis. However, large-scale, long-term, randomized clinical studies of mizoribine are lacking. OB... | JAMA network open | 03/03/2025 |
('LID', '10.1038/s42255-025-01235-8') | SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1. | Zhao, Qian, Jing, Ying, Jiang, Xiaoyu, Zhang, Xin, Liu, Feifei, Huang, Haoyan, Zhang, Zhihua, Wang, Haijun, Sun, Shuhui, Ma, Shuai, Zhang, Weiqi, Yu, Yang, Fu, Xiaobing, Zhao, Guoguang, Qu, Jing, Wang, Si, Liu, Guang-Hui | Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate sk... | Nature metabolism | 14/03/2025 |
('AID', '10.3347/kjp.1983.21.1.41') | [Aspartate And Alanine Aminotransferase In Fasciola Hepatica]. | Park, Sun Hyo, Kwon, Nyon Soo, Lee, Hi Sung, Song, Chul Yong | The activity and distribution of aspartate aminotransferase (EC 2.6.1.1) and alanine aminotransferase (EC 2.6.1.2) in adult Fasciola hepatica have been studied. Fasciola hepatica was fractionated by differential centrifugation into nuclear, mitochondrial and cytosolic fractions. The activity of GOT and GPT ... | Kisaengch'unghak chapchi. The Korean journal of parasitology | 00/06/1983 |
('LID', '10.1038/s41586-025-08721-9') | MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. | Fiorini, Elena, Malinova, Antonia, Schreyer, Daniel, Pasini, Davide, Bevere, Michele, Alessio, Giorgia, Rosa, Diego, D'Agosto, Sabrina, Azzolin, Luca, Milite, Salvatore, Andreani, Silvia, Lupo, Francesca, Veghini, Lisa, Grimaldi, Sonia, Pedron, Serena, Castellucci, Monica, Nourse, Craig, Salvia, Roberto, Malleo, Giusep... | Intratumour heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance(1,2). Oncogene dosage variation contributes to cell-state transitions and phenotypic heterogeneity(3), thereby providing a substrate for somatic evolution. Nonetheless, the genetic mechanisms underlying pheno... | Nature | 12/03/2025 |
('LID', '10.1016/j.jaci.2025.02.034') | Cigarette smoke-induced epithelial cell ferroptosis promotes neutrophilic inflammation in patients with nasal polyps. | Pan, Li, Yu, Ze, Xiang, Wen-Xuan, Sun, Shi-Ran, Li, Jing-Xian, Deng, Yi-Ke, Wang, Meng-Chen, Zhong, Ji-Xin, Huang, Kun, Gao, Pei-Song, Zhu, Li-Ping, Yao, Yin, Liu, Zheng | BACKGROUND: Regulation of epithelial cell death has emerged as a key mechanism maintaining immune homeostasis in the airway. However, the mechanisms governing epithelial cell survival in nasal polyps (NPs) remains poorly understood. OBJECTIVE: To investigate the ferroptosis of nasal epithelial cell and its ... | The Journal of allergy and clinical immunology | 12/03/2025 |
('LID', '10.1016/j.biortech.2011.11.059') | A novel and efficient method for the immobilization of thermolysin using sodium chloride salting-in and consecutive microwave irradiation. | Chen, Feifei, Zhang, Fangkai, Du, Fangchuan, Wang, Anming, Gao, Weifang, Wang, Qiuyan, Yin, Xiaopu, Xie, Tian | Sodium chloride salting-in and microwave irradiation were combined to drive thermolysin molecules into mesoporous support to obtain efficiently immobilized enzyme. When the concentration of sodium chloride was 3 M and microwave power was 40 W, 93.2% of the enzyme was coupled to the support by 3 min, and the... | Bioresource technology | 00/07/2012 |
('LID', '10.1016/j.ccell.2025.02.014') | Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy. | Song, Huan, Chen, Lin, Pan, Xuanxuan, Shen, Yuru, Ye, Maolin, Wang, Guohong, Cui, Can, Zhou, Qi, Tseng, Yujen, Gong, Zheng, Zhong, Bin, Cui, Haoshu, Mo, Shaocong, Zheng, Jiayue, Jin, Bryan, Zheng, Wanwei, Luo, Feifei, Liu, Jie | STING is an important DNA sensing machinery in initiating immune response, yet therapies targeting STING have shown poor outcomes in clinical trials. Here, we reveal that STING signaling induces PD-L1(hi) tumor monocytes (Tu.Mons) that dominate the resistance against STING agonist therapy. Cell-intrinsic PD... | Cancer cell | 10/03/2025 |
('LID', '10.1038/s42255-025-01246-5') | Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control. | Jiang, Zengliang, He, Liuqing, Li, Diyin, Zhuo, Laibao, Chen, Lingjun, Shi, Rui-Qi, Luo, Jianhua, Feng, Yuhui, Liang, Yuhui, Li, Danyang, Congmei, Xiao, Fu, Yuanqing, Chen, Yu-Ming, Zheng, Ju-Sheng, Tao, Liang | Obesity affects millions of people in the world. The gut microbiome influences body fat accumulation, but the mechanisms remain to be investigated. Here, we show an association between microbial aromatic amino acid metabolites in serum and body fat accumulation in a large Chinese longitudinal cohort. We nex... | Nature metabolism | 14/03/2025 |
('LID', '10.1002/cac2.70016') | Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages. | Zhao, Rongrong, Pan, Ziwen, Qiu, Jiawei, Li, Boyan, Qi, Yanhua, Gao, Zijie, Qiu, Wei, Tang, Weijie, Guo, Xiaofan, Deng, Lin, Li, Gang, Xue, Hao | BACKGROUND: Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti-PD-1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti-PD-1 therapy is necessary to design more effective immunotherapies for GBM. This study aimed to ... | Cancer communications (London, England) | 14/03/2025 |
('LID', '10.1182/blood.2024026622') | Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma. | Ma, Sha, Xia, Jieyun, Zhang, Miao, Li, Wenyu, Xiao, Meng, Sha, Yuqian, Wang, Wenya, Zhou, Jianteng, Wang, Ying, Qi, Kunming, Fu, Chunling, Sun, Zengtian, Zhou, Dian, Sun, Qian, Qiu, Tingting, Yan, Zhiling, Zhu, Feng, Chen, Wei, Cheng, Hai, Sang, Wei, Cao, Jiang, Li, Depeng, Li, Zhenyu Zhen, Fulciniti, Mariateresa, Yao,... | G protein-coupled receptor, class C, group 5, member D (GPRC5D) has emerged as a novel target for chimeric antigen receptor (CAR) T-cell therapy, demonstrating promising efficacy in multiple myeloma (MM). However, disease relapse is still common, and the mechanism of resistance remains poorly understood. In... | Blood | 16/03/2025 |
('LID', '10.1097/HEP.0000000000001302') | Pre-B-Cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in hepatic stellate cells. | Zhao, Qianwen, Liu, Hong, Yang, Zhen, Han, Xingxing, Kang, Aoqi, Li, Hao, Ren, Wenjing, Chen, Qianqian, Huan, Yue, Xu, Yong, Li, Jie, Kong, Ming, Li, Zilong | BACKGROUND AND AIMS: Liver fibrosis, when dysregulated, contributes to irreversible loss of hepatic structure and function heralding end-stage liver diseases including cirrhosis and hepatocellular carcinoma. Hepatic stellate cells (HSCs) represent the common progenitor to myofibroblasts that produce ext... | Hepatology (Baltimore, Md.) | 13/03/2025 |
('LID', '10.1146/annurev-immunol-101721-032910') | Regulation of the cGAS-STING Pathway. | Zhang, Bing, Xu, Pengbiao, Ablasser, Andrea | The cGAS-cGAMP-STING pathway is essential for immune defense against pathogens. Upon binding DNA, cGAS synthesizes cGAMP, which activates STING, leading to potent innate immune effector responses. However, lacking specific features to distinguish between self and nonself DNA, cGAS-STING immunity requires pr... | Annual review of immunology | 14/03/2025 |
('LID', '10.1038/s41467-025-57823-5') | Identification of a non-inhibitory aptameric ligand to CRL2(ZYG11B) E3 ligase for targeted protein degradation. | Yang, Zhihao, Chen, Miao, Ge, Ruixin, Zhou, Ping, Pan, Wei, Song, Jiayi, Ma, Shuwen, Chen, Song, Xu, Chenyu, Zhou, Mengyu, Mi, Wenyi, Ni, Hua, Chen, He, Yao, Xue, Dong, Xifeng, Chen, Yan, Zhou, Jun, Xuan, Chenghao, Dong, Cheng, Yan, Hua, Xie, Songbo | As a crucial element of proteolysis targeting chimeras (PROTACs), the choice of E3 ubiquitin ligase significantly influences degradation efficacy and selectivity. However, the available arsenal of E3 ligases for PROTAC development remains underexplored, severely limiting the scope of targeted protein de... | Nature communications | 13/03/2025 |
('LID', '10.1038/s43587-025-00816-2') | Interleukin-12 signaling drives Alzheimer's disease pathology through disrupting neuronal and oligodendrocyte homeostasis. | Schneeberger, Shirin, Kim, Seung Joon, Geesdorf, Maria N, Friebel, Ekaterina, Eede, Pascale, Jendrach, Marina, Boltengagen, Anastasiya, Braeuning, Caroline, Ruhwedel, Torben, Hülsmeier, Andreas J, Gimber, Niclas, Foerster, Marlene, Obst, Juliane, Andreadou, Myrto, Mundt, Sarah, Schmoranzer, Jan, Prokop, Stefan, Kessler... | Neuroinflammation including interleukin (IL)-12/IL-23-signaling is central to Alzheimer's disease (AD) pathology. Inhibition of p40, a subunit of IL-12/IL-23, attenuates pathology in AD-like mice; however, its signaling mechanism and expression pattern remained elusive. Here we show that IL-12 receptors are... | Nature aging | 13/03/2025 |
('LID', '10.1016/j.dsx.2025.103212') | Comparative efficacy and safety of semaglutide 2.4 mg and tirzepatide 5-15 mg in obesity with or without type 2 diabetes: A systematic review of Phase 3 clinical trials. | Singh, Akriti, Singh, Awadhesh Kumar, Singh, Ritu, Misra, Anoop | BACKGROUND AND AIMS: Both semaglutide 2.4 mg and tirzepatide have been recently approved for chronic use in obesity. There is a lack of literature comparing the efficacy and safety of both these agents in people with obesity/overweight with or without type 2 diabetes (T2D). We systematically reviewed Phase ... | Diabetes & metabolic syndrome | 08/03/2025 |
('LID', '10.1136/jitc-2024-010639') | Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer. | Duan, Jinlin, Chen, Tao, Li, Qiwei, Zhang, Yu, Lu, Ting, Xue, Junyan, Sun, Yang, Gao, Ling, Zhang, Yonglong | BACKGROUND: The emergence of immunotherapy has revolutionized the paradigm of cancer treatment with immune checkpoint blockades (ICB) in solid cancers, including colorectal cancer (CRC). However, only a small subset of CRC patients harboring deficient mismatch repair (dMMR) or microsatellite instability-hig... | Journal for immunotherapy of cancer | 13/03/2025 |
('LID', '10.1161/CIRCRESAHA.124.325049') | March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization. | Li, Yiran E, Liu, Shuolin, Wang, Litao, Du, Yuxin, Wu, Lin, Chen, Haoran, Zhu, Tingfang, Lin, Jie, Xiong, Shengjun, Wang, Yayu, Zheng, Qijun, Zou, Rongjun, Lin, Ling, Li, Zheyun, Wang, Lixin, Ge, Junbo, Ren, Jun, Zhang, Yingmei | BACKGROUND: Aortic aneurysm/dissection (AAD) is a life-threatening disease lacking effective pharmacological treatment. Protein ubiquitination plays a pivotal role in cardiovascular diseases. However, the possible contribution of the E3 ubiquitin ligase March2 (membrane-associated RING finger protein 2) to ... | Circulation research | 13/03/2025 |
('LID', '10.1016/j.neuron.2025.02.003') | Population coding of predator imminence in the hypothalamus. | Cheung, Kathy Y M, Nair, Aditya, Li, Ling-Yun, Shapiro, Mikhail G, Anderson, David J | Hypothalamic VMHdm(SF1) neurons are activated by predator cues and are necessary and sufficient for instinctive defensive responses. However, such data do not distinguish which features of a predator encounter are encoded by VMHdm(SF1) neural activity. To address this issue, we imaged VMHdm(SF1) neurons at ... | Neuron | 13/03/2025 |
('LID', '10.1016/j.ccell.2025.02.018') | Effective targeting of PDGFRA-altered high-grade glioma with avapritinib. | Mayr, Lisa, Neyazi, Sina, Schwark, Kallen, Trissal, Maria, Beck, Alexander, Labelle, Jenna, Eder, Sebastian K, Weiler-Wichtl, Liesa, Marques, Joana G, de Biagi-Junior, Carlos A O, Lo Cascio, Costanza, Chapman, Owen, Sridhar, Sunita, Kenkre, Rishaan, Dutta, Aditi, Wang, Shanqing, Wang, Jessica, Hack, Olivia, Nascimento,... | PDGFRA is crucial to tumorigenesis and frequently genomically altered in high-grade glioma (HGG). In a comprehensive dataset of pediatric HGG (n = 261), we detect PDGFRA mutations and/or amplifications in 15% of cases, suggesting PDGFRA as a therapeutic target. We reveal that the PDGFRA/KIT inhibitor av... | Cancer cell | 13/03/2025 |
('LID', '10.1016/j.cels.2025.101205') | Proliferation history and transcription factor levels drive direct conversion to motor neurons. | Wang, Nathan B, Lende-Dorn, Brittany A, Beitz, Adam M, Han, Patrick, Adewumi, Honour O, O'Shea, Timothy M, Galloway, Kate E | The sparse and stochastic nature of conversion has obscured our understanding of how transcription factors (TFs) drive cells to new identities. To overcome this limit, we develop a tailored, high-efficiency conversion system that increases the direct conversion of fibroblasts to motor neurons 100-fold. By t... | Cell systems | 11/03/2025 |
('LID', '10.1177/15333175251325091') | Automatic Detection of Cognitive Impairment in Patients With White Matter Hyperintensity Using Deep Learning and Radiomics. | Feng, Junbang, Le, Xingyan, Li, Li, Tang, Lin, Xia, Yuwei, Shi, Feng, Guo, Yi, Zhou, Yueqin, Li, Chuanming | White matter hyperintensity (WMH) is associated with cognitive impairment. In this study, 79 patients with WMH from hospital 1 were randomly divided into a training set (62 patients) and an internal validation set (17 patients). In addition, 29 WMH patients from hospital 2 were used as an external validatio... | American journal of Alzheimer's disease and other dementias | 00/01/2025 |
('LID', '10.1016/j.ccell.2025.02.018') | Effective targeting of PDGFRA-altered high-grade glioma with avapritinib. | Mayr, Lisa, Neyazi, Sina, Schwark, Kallen, Trissal, Maria, Beck, Alexander, Labelle, Jenna, Eder, Sebastian K, Weiler-Wichtl, Liesa, Marques, Joana G, de Biagi-Junior, Carlos A O, Lo Cascio, Costanza, Chapman, Owen, Sridhar, Sunita, Kenkre, Rishaan, Dutta, Aditi, Wang, Shanqing, Wang, Jessica, Hack, Olivia, Nascimento,... | PDGFRA is crucial to tumorigenesis and frequently genomically altered in high-grade glioma (HGG). In a comprehensive dataset of pediatric HGG (n = 261), we detect PDGFRA mutations and/or amplifications in 15% of cases, suggesting PDGFRA as a therapeutic target. We reveal that the PDGFRA/KIT inhibitor av... | Cancer cell | 13/03/2025 |
('LID', '10.1016/j.cels.2025.101205') | Proliferation history and transcription factor levels drive direct conversion to motor neurons. | Wang, Nathan B, Lende-Dorn, Brittany A, Beitz, Adam M, Han, Patrick, Adewumi, Honour O, O'Shea, Timothy M, Galloway, Kate E | The sparse and stochastic nature of conversion has obscured our understanding of how transcription factors (TFs) drive cells to new identities. To overcome this limit, we develop a tailored, high-efficiency conversion system that increases the direct conversion of fibroblasts to motor neurons 100-fold. By t... | Cell systems | 11/03/2025 |
('LID', '10.1177/15333175251325091') | Automatic Detection of Cognitive Impairment in Patients With White Matter Hyperintensity Using Deep Learning and Radiomics. | Feng, Junbang, Le, Xingyan, Li, Li, Tang, Lin, Xia, Yuwei, Shi, Feng, Guo, Yi, Zhou, Yueqin, Li, Chuanming | White matter hyperintensity (WMH) is associated with cognitive impairment. In this study, 79 patients with WMH from hospital 1 were randomly divided into a training set (62 patients) and an internal validation set (17 patients). In addition, 29 WMH patients from hospital 2 were used as an external validatio... | American journal of Alzheimer's disease and other dementias | 00/01/2025 |
('LID', '10.1126/sciadv.adr3757') | Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank. | Yi, Fan, Yuan, Jing, Somekh, Judith, Peleg, Mor, Zhu, Yi-Cheng, Jia, Zhilong, Wu, Fei, Huang, Zhengxing | Brain age gap (BAG), the deviation between estimated brain age and chronological age, is a promising marker of brain health. However, the genetic architecture and reliable targets for brain aging remains poorly understood. In this study, we estimate magnetic resonance imaging (MRI)-based brain age using dee... | Science advances | 14/03/2025 |
('LID', '10.1038/s41572-025-00600-x') | Primary sclerosing cholangitis. | Manns, Michael P, Bergquist, Annika, Karlsen, Tom H, Levy, Cynthia, Muir, Andrew J, Ponsioen, Cyriel, Trauner, Michael, Wong, Grace, Younossi, Zobair M | Primary sclerosing cholangitis (PSC) is a chronic biliary inflammation associated with periductular fibrosis of the intrahepatic and extrahepatic bile ducts leading to strictures, bacterial cholangitis, decompensated liver disease and need for liver transplantation. This rare focal liver disease affects all... | Nature reviews. Disease primers | 13/03/2025 |
('LID', '10.1001/jamanetworkopen.2025.0669') | Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial. | Bettocchi, Silvia, Comotti, Anna, Elli, Marina, De Cosmi, Valentina, Berti, Cristiana, Alberti, Ilaria, Mazzocchi, Alessandra, Rosazza, Chiara, Agostoni, Carlo, Milani, Gregorio Paolo | IMPORTANCE: Upper respiratory tract infections (URTIs) are prevalent in children, prompting frequent health care consultations, especially among those with fever. Probiotics show potential as an adjuvant treatment for URTIs, but evidence in children is limited. OBJECTIVE: To evaluate the efficacy of a probi... | JAMA network open | 03/03/2025 |
('LID', '10.1016/j.ygyno.2015.01.552') | Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons. | Bakkum-Gamez, Jamie N, Wentzensen, Nicolas, Maurer, Matthew J, Hawthorne, Kieran M, Voss, Jesse S, Kroneman, Trynda N, Famuyide, Abimbola O, Clayton, Amy C, Halling, Kevin C, Kerr, Sarah E, Cliby, William A, Dowdy, Sean C, Kipp, Benjamin R, Mariani, Andrea, Oberg, Ann L, Podratz, Karl C, Shridhar, Viji, Sherman, Mark E | OBJECTIVE: We demonstrate the feasibility of detecting EC by combining minimally-invasive specimen collection techniques with sensitive molecular testing. METHODS: Prior to hysterectomy for EC or benign indications, women collected vaginal pool samples with intravaginal tampons and underwent endometrial... | Gynecologic oncology | 00/04/2015 |
('LID', '10.1093/jimmun/vkaf005') | Sustained activation induced cytidine deaminase (AID) expression in B cells following Plasmodium falciparum malaria infection in Kenyan children. | Ariera, Bonface, Guyah, Bernard, Rahkola, Jeremy, Arao, Ian, Waomba, Kevin, Koech, Emmily, Samayoa-Reyes, Gabriela, Sabourin, Katherine R, Ogolla, Sidney, Rochford, Rosemary | Burkitt lymphoma (BL) is characterized by elevated levels of the enzyme activation-induced cytidine deaminase (AID), an enzyme critical for MYC translocation that is the hallmark of BL. Both EBV and Plasmodium falciparum malaria are cofactors in the etiology of BL. However, how these 2 pathogens drive B... | Journal of immunology (Baltimore, Md. : 1950) | 14/03/2025 |
('LID', '10.1016/j.annonc.2025.03.005') | Redefining Clinical Trial Strategic Design to Support Drug Approval in Medical Oncology. | Antonarelli, G, Pérez-García, J M, Gion, M, Rugo, H, Schmid, P, Bardia, A, Hurvitz, S, Harbeck, N, Tolaney, S M, Curigliano, G, Llombart-Cussac, A, Cortés, J | Randomized clinical trials represent the gold standard for the introduction of innovative therapies in medical oncology, and they provide the highest level of evidence to ascertain the clinical activity of new drugs or novel combinations. However, the current infrastructure of clinical trials supporting inn... | Annals of oncology : official journal of the European Society for Medical | 12/03/2025 |
('LID', '10.7554/eLife.96519') | A microglia clonal inflammatory disorder in Alzheimer's disease. | Vicario, Rocio, Fragkogianni, Stamatina, Weber, Leslie, Lazarov, Tomi, Hu, Yang, Hayashi, Samantha Y, Craddock, Barbara, Socci, Nicholas D, Alberdi, Araitz, Baako, Ann, Ay, Oyku, Ogishi, Masato, Lopez-Rodrigo, Estibaliz, Kappagantula, Rajya, Viale, Agnes, Iacobuzio-Donahue, Christine A, Zhou, Ting, Ransohoff, Richard M... | Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have investigated its role in neurodegenerative processes such as Alzheimer's disease (AD). Here, we report the selective enrichment of microglia clones carryin... | eLife | 14/03/2025 |
('LID', '10.1016/j.amjmed.2025.03.010') | Vaccines for International Travelers: Current Status and Recent Developments. | Murray, Henry W | Immunizations, malaria chemoprophylaxis, insect repellent use, and prevention and management of travelers' diarrhea are the cornerstones of the pretravel consultation. This report updates one of these topics, vaccine immunizations, for adult international travelers. | The American journal of medicine | 12/03/2025 |
('LID', '10.1021/acsami.4c19748') | Stem Cells from Human Exfoliated Deciduous Teeth-Derived Exosomes for the Treatment of Acute Liver Injury and Liver Fibrosis. | Wang, Ziyuan, Zhong, Danyang, Yan, Tingting, Zheng, Qiang, Zhou, Enjie, Ye, Zhichao, He, Xiaoyan, Liu, Yu, Yan, Jianing, Yuan, Yuyang, Wang, Yifan, Cai, Xiujun | Mesenchymal stem cells (MSCs) play a crucial role in regenerative medicine due to their regenerative potential. However, traditional MSC-based therapies are hindered by issues such as microvascular obstruction and low cell survival after transplantation. Exosomes derived from MSCs (MSC-Exo) provide a cell-f... | ACS applied materials & interfaces | 14/03/2025 |
('LID', '10.1002/advs.202413125') | Integration of Circulating Tumor DNA and Metabolic Parameters on (18)F-Fludeoxyglucose Positron Emission Tomography for Outcome Prediction in Unresectable Locally Advanced Non-Small Cell Lung Cancer. | Wu, Leilei, Zhang, Zhenshan, Jiang, Chenxue, Li, Li, Sun, Xiaojiang, Bai, Menglin, Liu, Ming, Xiong, Kangli, Shang, Jinbiao, Yu, Jinming, Yuan, Shuanghu, Yang, Yang, Xu, Yaping | This prospective study explores the prognostic value of circulating tumor DNA (ctDNA) and positron emission tomography/computed tomograpy (PET/CT) in unresectable locally advanced non-small cell lung cancer (LA-NSCLC) treated with definitive chemoradiotherapy (CRT). The discovery set includes 62 patients, w... | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 16/03/2025 |
('LID', '10.1182/blood.2024025440') | A TIM-3-Fc decoy secreted by engineered T cells improves CD19 CAR-T cell therapy in B-cell acute lymphoblastic leukemia. | Falgàs, Aïda, Lázaro-Gorines, Rodrigo, Zanetti, Samanta Romina, Rubio-Pérez, Laura, Martinez-Moreno, Alba, Vinyoles, Meritxell, Guerrero-Murillo, Mercedes, Fernandez-Fuentes, Narcís, Roca-Ho, Heleia, Tirado, Néstor, Panisello, Carla, Velasco-Hernandez, Talía, Mayado, Andrea, Pérez-Pons, Alba, Genesca, Eulalia, Ribera, ... | Relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging disease with a dismal prognosis. Despite the revolutionary impact of CD19-directed chimeric antigen receptor (CAR19)-T cell therapy, >50% of patients relapse within a year. Both leukemia cell-intrinsic factors fav... | Blood | 16/03/2025 |
('LID', '10.1016/S2352-3026(24)00377-6') | Talicabtagene autoleucel for relapsed or refractory B-cell malignancies: results from an open-label, multicentre, phase 1/2 study. | Jain, Hasmukh, Karulkar, Atharva, Kalra, Devanshi, Ravikumar, Smrithi, Shah, Shreshtha, Firfiray, Afrin, Pendhari, Juber, Jaiswal, Ankesh Kumar, Khan, Aalia, Sundharam, Manivasagam, Vaibhaw, Anand, Saroha, Ashish, Rajyopadhye, Shreewardhan, Basu, Moumita, Asija, Sweety, Chowdhury, Ambalika, Beher, Rohit, Banik, Ankit, ... | BACKGROUND: In low-income and middle-income counties (LMICs), the outcome of relapsed or refractory B-cell malignancies is poor due to the absence of effective therapies. We report the results of a phase 1/2 study of a novel humanised anti-CD19 4-1BB chimeric antigen receptor (CAR) T-cell therapy, talic... | The Lancet. Haematology | 13/03/2025 |
('LID', '10.1126/sciadv.ads8694') | A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections. | Zheng, Fuyuan, Wan, Xufeng, Zhang, Yangming, Yue, Yan, Li, Qiaochu, Zhang, Zhuang, Li, Shuoyuan, Xu, Hong, Su, Qiang, Chen, Xiaoting, Tong, Le, Zhao, Long, Cao, Jian, Tang, Xin, Yang, Xiao, Wu, Jiagang, Li, Jian, Lv, Xiang, Zhou, Zongke, Wang, Duan | Tracking and eradicating drug-resistant bacteria are critical for combating implant-associated infections, yet effective antibacterial therapies remain elusive. Herein, we propose an oxygen vacancy-rich (BiFe)(0.9)(BaTi)(0.1)O(3-)(x) nanoreactor as a piezoelectric sonosensitizer by spatiotemporal ultrasound... | Science advances | 14/03/2025 |
('LID', '10.1038/s41586-025-08697-6') | TGFβ links EBV to multisystem inflammatory syndrome in children. | Goetzke, Carl Christoph, Massoud, Mona, Frischbutter, Stefan, Guerra, Gabriela Maria, Ferreira-Gomes, Marta, Heinrich, Frederik, von Stuckrad, Anne Sae Lim, Wisniewski, Sebastian, Licha, Jan Robin, Bondareva, Marina, Ehlers, Lisa, Khaldi-Plassart, Samira, Javouhey, Etienne, Pons, Sylvie, Trouillet-Assant, Sophie, Ozsur... | In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock(1) termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion(2) and systemic hyperinflammation(3). The... | Nature | 12/03/2025 |
('LID', '10.1016/j.cell.2025.02.009') | Engineering mtDNA deletions by reconstituting end joining in human mitochondria. | Fu, Yi, Land, Max, Kavlashvili, Tamar, Cui, Ruobing, Kim, Minsoo, DeBitetto, Emily, Lieber, Toby, Ryu, Keun Woo, Choi, Elim, Masilionis, Ignas, Saha, Rahul, Takizawa, Meril, Baker, Daphne, Tigano, Marco, Lareau, Caleb A, Reznik, Ed, Sharma, Roshan, Chaligne, Ronan, Thompson, Craig B, Pe'er, Dana, Sfeir, Agnel | Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of genomes carrying pathogenic mutations. However, reconstituting mtDNA deletions linked to mitochondrial myopathies remains challenging. Here, we engineered mt... | Cell | 05/03/2025 |
('LID', '10.1186/s40337-023-00900-1') | A case series to test the acceptability, feasibility and preliminary efficacy of AVATAR therapy in anorexia nervosa. | Thompson, Alistair, Calissano, Chiara, Treasure, Janet, Ball, Hannah, Montague, Alice, Ward, Thomas, Cardi, Valentina | BACKGROUND: Patients with anorexia nervosa tend to experience an inner "eating disorder" voice. They struggle to recognise and assert their own identity over the illness's identity and relate to it from a powerless and subordinate position. AVATAR therapy was developed to help patients with psychosis to gai... | Journal of eating disorders | 13/10/2023 |
('LID', '10.1038/s41467-025-57924-1') | Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice. | Chi, Dongmei, Zhang, Kun, Zhang, Jianxing, He, Zhaoli, Zhou, Hongxia, Huang, Wan, Liu, Yang, Huang, Jingxiu, Zeng, Weian, Bai, Xiaohui, Ou, Chaopeng, Ouyang, Handong | Astrocytes are closely linked to depression, and the prefrontal cortex (PFC) is an important brain region involved in major depressive disorder (MDD). However, the underlying mechanism by which astrocytes within PFC contribute to MDD remains unclear. Using single-nucleus RNA sequencing analyses, we show a s... | Nature communications | 14/03/2025 |
('LID', '10.1093/cvr/cvaf023') | Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorr... | Davidson, Sean M, Andreadou, Ioanna, Antoniades, Charalambos, Bartunek, Jozef, Basso, Cristina, Brundel, Bianca J J M, Byrne, Robert A, Chiva-Blanch, Gemma, da Costa Martins, Paula, Evans, Paul C, Girão, Henrique, Giricz, Zoltan, Gollmann-Tepeköylü, Can, Guzik, Tomasz, Gyöngyösi, Mariann, Hübner, Norbert, Joner, Michae... | Animal models offer invaluable insights into disease mechanisms but cannot entirely mimic the variability and heterogeneity of human populations, nor the increasing prevalence of multi-morbidity. Consequently, employing human samples-such as whole blood or fractions, valvular and vascular tissues, myoca... | Cardiovascular research | 14/03/2025 |
('LID', '10.1097/HEP.0000000000001307') | HLA-DQB1*03:01 and risk of Hepatitis B virus-related hepatocellular carcinoma. | Zhang, Ting, Huang, Chih-Jen, Chen, Hai-Tao, Huang, Yu-Han, Pan, Mei-Hung, Lee, Mei-Hsuan, Viard, Mathias, Hildesheim, Allan, Pfeiffer, Ruth M, Carrington, Mary, Chen, Chien-Jen, Zhu, Bin, Lenz, Tobias L, Jiang, Deke, Yang, Hwai-I, Liu, Zhiwei | BACKGROUND AIMS: The human leukocyte antigen (HLA) locus is implicated in hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers. We investigated associations of HLA variants, amino acid polymorphisms, zygosity, and evolutionary divergence (HED) with HBV-related HCC in Han Chinese and... | Hepatology (Baltimore, Md.) | 14/03/2025 |
('LID', '10.1016/j.ccell.2025.02.015') | Hypoxia inducible factor-1α drives cancer resistance to cuproptosis. | Yang, Zhou, Su, Wei, Wei, Xiyi, Pan, Yitong, Xing, Mengying, Niu, Lili, Feng, Baijie, Kong, Weiyu, Ren, Xiaohan, Huang, Feng, Zhou, Jingwan, Zhao, Wei, Qiu, Yingyi, Liao, Tian, Chen, Qi, Qu, Shuang, Wang, Yunjun, Guan, Qing, Li, Duanshu, Zen, Ke, Chen, Yun, Qin, Chao, Wang, Yu, Zhou, Xiang, Xiang, Jun, Yao, Bing | Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME). Here we reveal that hypoxia inducible factor-1α (HIF-1α) is a driver of cuproptosis res... | Cancer cell | 04/03/2025 |
('LID', '10.1038/s41467-025-57610-2') | A skin organoid-based infection platform identifies an inhibitor specific for HFMD. | Li, Jun, Ma, Jie, Cao, Ruiyuan, Zhang, Qiyu, Li, Mansheng, Wang, Wenwen, Wang, Yujie, Li, Wei, Zhu, Yunping, Leng, Ling | The EV-A71 poses a serious threat to the health and lives of children. The EV-A71 can be transmitted by direct and indirect skin contact. Therefore, there is an urgent need to create novel skin models using human-derived cells to study the biology and pathogenesis of the virus and facilitate drug screening.... | Nature communications | 13/03/2025 |
('LID', '10.1186/s12933-025-02670-3') | Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease. | Li, Yujian, Li, Dun, Lin, Jing, Zhou, Lihui, Yang, Weiling, Yin, Xin, Xu, Chenjie, Cao, Zhi, Wang, Yaogang | Emerging evidence reveals a complex association between type 2 diabetes (T2D) and coronary heart disease (CHD), which share common risk factors and biological pathways. This study aims to identify the shared proteomic signatures of T2D and CHD, as well as whether the shared proteins predict incident CHD in ... | Cardiovascular diabetology | 14/03/2025 |
('LID', '10.1148/rycan.240213') | Deep Learning Radiopathomics Models Based on Contrast-enhanced MRI and Pathologic Imaging for Predicting Vessels Encapsulating Tumor Clusters and Prognosis in Hepatocellular Carcinoma. | Yu, Yixing, Cao, Lixiu, Shen, Binqing, Du, Mingzhan, Gu, Wenhao, Gu, Chunyan, Fan, Yanfen, Shi, Cen, Wu, Qian, Zhang, Tao, Zhu, Mo, Wang, Ximing, Hu, Chunhong | Purpose To develop deep learning (DL) radiopathomics models based on contrast-enhanced MRI and pathologic imaging to predict vessels encapsulating tumor clusters (VETC) and survival in hepatocellular carcinoma (HCC). Materials and Methods In this retrospective, multicenter study, 578 patients with HCC (mean... | Radiology. Imaging cancer | 00/03/2025 |
('LID', '10.1007/s13304-025-02166-5') | Diagnosis and management of caustic ingestion: an interdisciplinary nationwide cross-sectional survey from the Italian society of endoscopic surgery and new technologies (SICE), the Italian society of digestive endoscopy (SIED), the world society of emergency surgery-Italy chapter (WSESit), and the Italian ... | Giordano, Alessio, Mastronardi, Manuela, Podda, Mauro, Bonavina, Luigi, Cuccurullo, Diego, Anania, Gabriele, Bergamini, Carlo, Galloro, Giuseppe, Hassan, Cesare, Parodi, Maria Caterina, Agresta, Ferdinando, Montori, Giulia, Sartelli, Massimo, Catena, Fausto, Fugazzola, Paola, Ansaloni, Luca, Marciano, Emanuele, Geraci,... | Caustic ingestion (CI) in adults represents a potentially life-threatening condition. Diagnosis and management of CI in real life remain challenging. The aim of the survey is to evaluate on a national scale the multidisciplinary management of these patients. 24-item online Survey was sent to the mailing lis... | Updates in surgery | 13/03/2025 |
('LID', '10.1016/j.cell.2025.02.010') | Genome-scale resources in the infant gut symbiont Bifidobacterium breve reveal genetic determinants of colonization and host-microbe interactions. | Shiver, Anthony L, Sun, Jiawei, Culver, Rebecca, Violette, Arvie, Wynter, Char, Nieckarz, Marta, Mattiello, Samara Paula, Sekhon, Prabhjot Kaur, Bottacini, Francesca, Friess, Lisa, Carlson, Hans K, Wong, Daniel P G H, Higginbottom, Steven, Weglarz, Meredith, Wang, Weigao, Knapp, Benjamin D, Guiberson, Emma, Sanchez, Ju... | Bifidobacteria represent a dominant constituent of human gut microbiomes during infancy, influencing nutrition, immune development, and resistance to infection. Despite interest in bifidobacteria as a live biotic therapy, our understanding of colonization, host-microbe interactions, and the health-promoting... | Cell | 07/03/2025 |
('LID', '10.1016/j.immuni.2025.02.008') | Lactate: A key regulator of the immune response. | Llibre, Alba, Kucuk, Salih, Gope, Atrayee, Certo, Michelangelo, Mauro, Claudio | Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells-with the latter process known as the Warburg effect-is historically considered a mere waste product of cell and tissue metabolism. However, research over the past ten years has unveiled multifaceted func... | Immunity | 11/03/2025 |
('LID', '10.1016/j.apnr.2025.151911') | Effects of a 12-week lower limb resistance training with breathing regulation in patients with diabetes-related foot ulcers: A randomized controlled trial. | Wu, Jia-Ling, Yeh, Mei-Ling, Liao, Jocelyn | Patients with diabetes-related foot ulcers may require hospitalization and face an increased risk of amputation, which can significantly impact their quality of life. One potential solution is exercise, which can regulate blood glucose levels, improve wound healing, and enhance overall well-being. This rand... | Applied nursing research : ANR | 00/04/2025 |
('LID', '10.1182/blood.2024027999') | Clonal Hematopoiesis Landscape in Frequent Blood Donors. | Karpova, Darja, Huerga Encabo, Hector Dr, Donato, Elisa, Calderazzo, Silvia, Scherer, Michael, Llorian-Sopena, Miriam, Leppä, Aino-Maija, Würth, Roberto, Stelmach, Patrick, Papazoglou, Despoina, Ferrelli, Alessandra, Ngo, Steven, Kotova, Iuliia, Harenkamp, Sabine, Zimmer, Kai, Wolf, Dominik, Panten, Jasper, Reed, John,... | Donor blood saves lives, yet the potential impact of recurrent large-volume phlebotomy on donor health and hematopoietic stem cells (HSCs) remains largely unexplored. In our study, we conducted a comprehensive screening of 217 older male volunteer donors with a history of extensive blood donation (>100 life... | Blood | 11/03/2025 |
('LID', '10.1111/jocd.70102') | Finasteride Use: Evaluation of Depression and Suicide Risk. | Gupta, Aditya K, Bamimore, Mary A, Williams, Greg, Talukder, Mesbah | BACKGROUND: Oral finasteride 1 mg/day is indicated for androgenetic alopecia (AGA), while 5 mg/day is for benign prostatic hyperplasia (BPH). Oral finasteride has been linked with depression and suicide; however, a causal association is uncertain. The so-called post-finasteride syndrome (PFS) refers to a "c... | Journal of cosmetic dermatology | 00/03/2025 |
('LID', '10.1016/j.cell.2025.02.013') | Crop root bacterial and viral genomes reveal unexplored species and microbiome patterns. | Dai, Rui, Zhang, Jingying, Liu, Fang, Xu, Haoran, Qian, Jing-Mei, Cheskis, Shani, Liu, Weidong, Wang, Binglei, Zhu, Honghui, Pronk, Lotte J U, Medema, Marnix H, de Jonge, Ronnie, Pieterse, Corné M J, Levy, Asaf, Schlaeppi, Klaus, Bai, Yang | Reference genomes of root microbes are essential for metagenomic analyses and mechanistic studies of crop root microbiomes. By combining high-throughput bacterial cultivation with metagenomic sequencing, we constructed comprehensive bacterial and viral genome collections from the roots of wheat, rice, maize... | Cell | 10/03/2025 |
('LID', '10.1038/s41467-025-57452-y') | Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes. | Sevilla-González, Magdalena, Smith, Kirk, Wang, Ningyuan, Jensen, Aubrey E, Litkowski, Elizabeth M, Kim, Hyunkyung, DiCorpo, Daniel A, Hsu, Sarah, Cui, Jinrui, Liu, Ching-Ti, Yu, Chenglong, McNeil, John J, Lacaze, Paul, Westerman, Kenneth E, Chang, Kyong-Mi, Tsao, Philip S, Phillips, Lawrence S, Goodarzi, Mark O, Slade... | Elevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distin... | Nature communications | 15/03/2025 |
('LID', '10.1186/s12943-025-02288-9') | ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma. | Bandi, Dhana Sekhar Reddy, Nagaraju, Ganji Purnachandra, Sarvesh, Sujith, Carstens, Julienne L, Foote, Jeremy B, Graff, Emily C, Fang, Yu-Hua D, Keeton, Adam B, Chen, Xi, Valiyaveettil, Jacob, Berry, Kristy L, Bae, Sejong, Akce, Mehmet, Gorman, Greg, Yoon, Karina J, Manne, Upender, Boyd, Michael R, Buchsbaum, Donald J,... | BACKGROUND: Oncogenic KRAS mutations occur in nearly, 90% of patients with pancreatic ductal adenocarcinoma (PDAC). Targeting KRAS has been complicated by mutational heterogeneity and rapid resistance. We developed a novel pan-RAS inhibitor, ADT-1004 (an oral prodrug of ADT-007) and evaluated antitumor acti... | Molecular cancer | 13/03/2025 |
('LID', '10.1111/acel.70022') | Phosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging. | Yeom, Eunbyul, Mun, Hyejin, Lim, Jinhwan, Chun, Yoo Lim, Min, Kyung-Won, Lambert, Johana, Cowart, L Ashley, Pierce, Jason S, Ogretmen, Besim, Cho, Jung-Hyun, Chang, Jeong Ho, Buchan, J Ross, Pitt, Jason, Kaeberlein, Matt, Kang, Sung-Ung, Kwon, Eun-Soo, Ko, Seungbeom, Choi, Kyoung-Min, Lee, Yong Sun, Ha, Yoon-Su, Kim, S... | The metazoan lifespan is determined in part by a complex signaling network that regulates energy metabolism and stress responses. Key signaling hubs in this network include insulin/IGF-1, AMPK, mTOR, and sirtuins. The Hippo/Mammalian Ste20-like Kinase1 (MST1) pathway has been reported to maintain lifespan i... | Aging cell | 11/03/2025 |
('LID', '10.1080/0886022X.2025.2471016') | The association between nutritional-inflammatory status and chronic kidney disease prognosis: a population-based study. | Zhang, Xinyu, Hu, Xuanhan, Qian, Lin, Chen, Zeqi, Hua, Xintao, Zhang, Dahong, Wei, Haibin | BACKGROUND: Chronic kidney disease (CKD) prognosis is closely tied to the interplay between nutrition and inflammation. However, comprehensive nutritional-inflammatory indices for prognostic evaluation are rare in CKD. This study explored the association of the advanced lung cancer inflammation index (A... | Renal failure | 00/12/2025 |
('LID', '10.1182/blood.2024027336') | Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study. | Kuter, David J, Ghanima, Waleed, Cooper, Nichola, Liebman, Howard Allen, Zhang, Lei, Hu, Yu, Miyakawa, Yoshitaka, Homenda, Wojciech, Morales Galindo, Luisa Elena Elena MD, Basquiera, Ana Lisa, Tan, Chuen Wen, Saydam, Guray Prof Dr, Hütter-Krönke, Marie Luise, Chai-Adisaksopha, Chatree, Gomez-Almaguer, David, Tran, Huy,... | Rilzabrutinib is a covalent, reversible BTK inhibitor with multiple mechanisms targeting key immune thrombocytopenia (ITP) disease pathophysiology. The phase 3 LUNA3 study in previously treated adults with persistent/chronic ITP evaluated oral rilzabrutinib 400 mg bid (n=133) vs placebo (n=69) for 24 weeks.... | Blood | 16/03/2025 |
('LID', '10.1016/j.cgh.2025.01.016') | Proton Pump Inhibitors for Inducing and Maintaining Remission in Eosinophilic Esophagitis: An Updated Systematic Review and Meta-Analysis. | Lucendo, Alfredo J, Gutiérrez-Ramírez, Lucía, Tejera-Muñoz, Antonio, Molina-Infante, Javier, Arias, Ángel | BACKGROUND & AIMS: Proton pump inhibitor (PPI) therapy results in clinical and histological remission in approximately 50% of eosinophilic esophagitis (EoE) patients. We aimed to systematically update this topic due to cumulative data from pediatric/adult populations in wider geographical settings. METHODS:... | Clinical gastroenterology and hepatology : the official clinical practice journal | 13/03/2025 |
('LID', '10.1038/s43856-025-00785-y') | Identifying and ranking non-traditional risk factors for cardiovascular disease prediction in people with type 2 diabetes. | Dziopa, Katarzyna, Chaturvedi, Nishi, Asselbergs, Folkert W, Schmidt, Amand F | BACKGROUND: Cardiovascular disease (CVD) prediction models perform poorly in people with type 2 diabetes (T2DM). We aimed to identify potentially non-traditional CVD predictors for six facets of CVD (including coronary heart disease, ischemic stroke, heart failure, and atrial fibrillation) in people with ... | Communications medicine | 14/03/2025 |
('LID', '10.1016/j.ygyno.2019.11.028') | Combining copy number, methylation markers, and mutations as a panel for endometrial cancer detection via intravaginal tampon collection. | Sangtani, Ajleeta, Wang, Chen, Weaver, Amy, Hoppman, Nicole L, Kerr, Sarah E, Abyzov, Alexej, Shridhar, Viji, Staub, Julie, Kocher, Jean-Pierre A, Voss, Jesse S, Podratz, Karl C, Wentzensen, Nicolas, Kisiel, John B, Sherman, Mark E, Bakkum-Gamez, Jamie N | OBJECTIVE: We aimed to assess whether endometrial cancer (EC) can be detected in shed DNA collected with vaginal tampon by analyzing copy number, methylation markers, and mutations. METHODS: Tampons were collected prior to hysterectomy from 38 EC patients and 28 women with benign indications. Extracted tamp... | Gynecologic oncology | 00/02/2020 |
('LID', '10.1016/j.esmoop.2025.104301') | The role of physical activity, sedentary behaviour, diet, adiposity and body composition on health-related quality of life and cancer-related fatigue after diagnosis of colorectal cancer: a Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis. | Markozannes, G, Cividini, S, Aune, D, Becerra-Tomás, N, Kiss, S, Balducci, K, Vieira, R, Cariolou, M, Jayedi, A, Greenwood, D C, Brockton, N T, Croker, H, Mitrou, P, Copson, E, Renehan, A G, Bours, M, Demark-Wahnefried, W, Hudson, M M, May, A M, Odedina, F T, Skinner, R, Steindorf, K, Tjønneland, A, Velikova, G, Baskin... | BACKGROUND: The impact of physical activity, sedentary behaviour, diet, adiposity, and body composition on health-related quality of life (HRQoL) and cancer-related fatigue among colorectal cancer survivors remains uncertain. METHODS: PubMed, Embase, and CENTRAL were systematically searched until April ... | ESMO open | 13/03/2025 |
('LID', '10.7189/jogh.15.04025') | The impact of physical activity on inhibitory control of adult ADHD: a systematic review and meta-analysis. | Yang, Yi, Wu, Chang-Hong, Sun, Liang, Zhang, Ting-Ran, Luo, Jiong | OBJECTIVE: We aimed to Investigate physical activity's effects on inhibitory control in adult attention deficit hyperactivity disorder (ADHD).The benefits of physical activity on the inhibitory control of adult ADHD were explored in the hope of providing some suggestions for approaches to treating adult ADH... | Journal of global health | 14/03/2025 |
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