Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice. | This study was designed to investigate the effects of dried plum on the changes in bone metabolism and the immune response associated with ovarian hormone deficiency. Adult female C57BL/6J mice were either sham-operated (Sham) and fed AIN-93 diet (control) or ovariectomized (OVX) and fed a control diet with 0%, 5%, 15%... | ['Animals', 'Biomarkers', 'Body Weight', 'Bone Density', 'Bone Marrow Cells', 'Bone and Bones', 'Concanavalin A', 'Cytokines', 'Dietary Supplements', 'Disease Models, Animal', 'Eating', 'Female', 'Femur', 'Gene Expression', 'Insulin-Like Growth Factor I', 'Mice', 'Mice, Inbred C57BL', 'Organ Size', 'Osteoporosis', 'Ova... | 21,414,765 | [['B01.050'], ['D23.101'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G11.427.100'], ['A11.148', 'A15.378.316'], ['A02.835.232', 'A10.165.265'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Concussion Attitudes and Beliefs, Knowledge, and Clinical Practice: Survey of Physical Therapists. | BACKGROUND: A concussion is considered a mild traumatic brain injury that may cause physical, cognitive, affective, and sleep dysfunction. Physical therapists have been identified as health care providers involved in the multidisciplinary care of a patient with concussion.OBJECTIVE: The purpose of this study was to des... | ['Adult', 'Attitude of Health Personnel', 'Brain Concussion', 'Clinical Competence', 'Decision Making', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Physical Therapists', 'Referral and Consultation', 'Return to Sport', 'Self Efficacy', 'Surveys and Questionnaires', 'Trauma Severi... | 26,637,654 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['C10.228.140.199.444.250', 'C10.900.300.087.235.250', 'C10.900.300.350.300', 'C26.915.300.200.194.250', 'C26.915.300.450.500', 'C26.974.382.200'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['F02.463.785.373'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Nerve conduction velocity in human limbs with late sequelae after local cold injury. | Cold-induced neuropathy may play a dominant role in the long-term sequelae with cold sensitivity after local cold injuries (LCIs). Somatosensory functions were assessed and nerve conduction velocity (NCV) and motor distal delay (MDD) were measured in the limbs of 31 Norwegian former soldiers with persistent cold intole... | ['Adult', 'Cold Temperature', 'Forearm', 'Frostbite', 'Humans', 'Hypersensitivity', 'Leg', 'Motor Neurons', 'Neural Conduction', 'Neurons, Afferent', 'Pain Measurement'] | 8,817,155 | [['M01.060.116'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['A01.378.800.585'], ['C26.212.500', 'C26.417'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543'], ['A01.378.610.500'], ['A08.675.655.500', 'A11.671.655.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Concomitant replacement of language and mtDNA in South Caspian populations of Iran. | The Gilaki and Mazandarani occupy the South Caspian region of Iran and speak languages belonging to the North-Western branch of Iranian languages . It has been suggested that their ancestors came from the Caucasus region, perhaps displacing an earlier group in the South Caspian . Linguistic evidence supports this scena... | ['Chromosomes, Human, Y', 'DNA, Mitochondrial', 'Female', 'Genetics, Population', 'Geography', 'Haplotypes', 'Humans', 'Iran', 'Language', 'Male', 'Polymorphism, Single Nucleotide'] | 16,581,511 | [['A11.284.187.520.300.505.757', 'A11.284.187.865.983.500', 'G05.360.162.520.300.505.757', 'G05.360.162.865.983.500'], ['D13.444.308.283.225'], ['H01.158.273.343.335'], ['H01.277.500'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['F01.145.209.399', 'L01.559'], ['G05.365.7... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
[Activated coagulation time and the concentration of heparin in assessing the level of blood heparinization during operations using artificial blood circulation]. | Blood heparinization was assessed, using two techniques (activated coagulation time--ACT and heparin concentration) in 31 patients during cardiopulmonary bypass surgery. It has been shown that ACT-technique, not always revealing heparin concentration, may serve as a criterion for blood heparinization adequacy during ca... | ['Adolescent', 'Adult', 'Blood Coagulation Tests', 'Cardiac Surgical Procedures', 'Child', 'Child, Preschool', 'Extracorporeal Circulation', 'Female', 'Heparin', 'Humans', 'Male', 'Middle Aged', 'Whole Blood Coagulation Time'] | 2,742,179 | [['M01.060.057'], ['M01.060.116'], ['E01.370.225.625.115', 'E05.200.625.115'], ['E04.100.376', 'E04.928.220'], ['M01.060.406'], ['M01.060.406.448'], ['E04.292'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.625.115.950', 'E05.200.625.115.950', 'G09.188.960']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Eye health outreach services in the Pacific Islands region: an updated profile. | BACKGROUND: Anecdotal reports indicate a decreasing number of patients presenting for assessment, and in particular a reduction in the number of patients requiring cataract surgery in Pacific Island Countries (PICs). Furthermore, research and routine surveillance is uncommon.AIM: To analyse and describe the records of ... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Ambulatory Care Facilities', 'Community Health Services', 'Community Networks', 'Community-Institutional Relations', 'Eye Diseases', 'Female', 'Health Services Accessibility', 'Humans', 'Male', 'Middle Aged', 'Pacific Islands', 'Vision Disorders'] | 26,367,510 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['N02.278.035'], ['N02.421.143'], ['I01.880.853.500.300', 'L01.313.500.750.300.184', 'N02.421.143.202'], ['N04.452.822.210'], ['C11'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Cost Efficacy of Metal Stents for Palliation of Extrahepatic Bile Duct Obstruction in a Randomized Controlled Trial. | BACKGROUND & AIMS: Endoscopic stents are placed for palliation of extrahepatic bile duct obstruction. Although self-expandable metal stents (SEMS) remain patent longer than plastic stents, they are more expensive. We aimed to evaluate which type of stent (plastic, uncovered SEMS [uSEMS], or partially covered SEMS [pcSE... | ['Aged', 'Aged, 80 and over', 'Bile Ducts, Extrahepatic', 'Cholangiopancreatography, Endoscopic Retrograde', 'Cholestasis, Extrahepatic', 'Cost-Benefit Analysis', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Metals', 'Middle Aged', 'Palliative Care', 'Stents', 'Treatment Outcome'] | 25,790,742 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A03.159.183.079'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E04.210.240.160', 'E04.502.250.250.160'], ['C06.130.120.135.150'], ['N03.219.151.125'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350',... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Angiosarcoma associated with germ cell tumors. | In two patients with malignant germ cell tumors angiosarcoma developed through two apparently different mechanisms. In one case the angiosarcoma probably developed as a complication of therapeutic radiation, since radiation changes were demonstrated in tissue adjacent to the neoplasm and since the angiosarcoma was not ... | ['Adolescent', 'Adult', 'Dose-Response Relationship, Radiation', 'Hemangiosarcoma', 'Humans', 'Immunoenzyme Techniques', 'Male', 'Mediastinal Neoplasms', 'Microscopy, Electron', 'Neoplasms, Germ Cell and Embryonal', 'Radiotherapy', 'Teratoma', 'Testicular Neoplasms'] | 2,982,720 | [['M01.060.057'], ['M01.060.116'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['C04.557.450.795.390', 'C04.557.645.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['C04.588.894.479', 'C08.846.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Creation of a safety culture: reducing workplace injuries in a rural hospital setting. | A newly organized employee safety program, with an 11-step design, has been introduced at Valley General Hospital in Monroe, Washington, with the intention of changing the "culture of safety." A 1-year report of the results indicates that the overall incidence of injury claims, lost-time injuries, and needlestick injur... | ['Absenteeism', 'Accidents, Occupational', 'Ergonomics', 'Health Knowledge, Attitudes, Practice', 'Hospitals, General', 'Hospitals, Rural', 'Humans', 'Incidence', 'Lifting', 'Needlestick Injuries', 'Needs Assessment', 'Occupational Health', 'Organizational Culture', 'Organizational Objectives', 'Personnel, Hospital', '... | 16,193,911 | [['F02.784.692.107'], ['N06.850.135.240'], ['F02.784.412', 'J01.293.556'], ['F01.100.150.500', 'N05.300.150.410'], ['N02.278.421.389'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'H... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Results of 75 lung transplantations performed in Groningen in 1990-1995. Lung Transplantation Group Groningen]. | OBJECTIVE: To describe the development of the lung transplantation programme in Groningen, and the results of single and bilateral lung transplantations in the first 75 consecutive patients, up to December 1995.DESIGN: Retrospective.SETTING: Academic Hospital Groningen, the Netherlands.METHODS: The results of the lung ... | ['Adolescent', 'Adult', 'Child', 'Cystic Fibrosis', 'Humans', 'Hypertension, Pulmonary', 'Lung Diseases', 'Lung Transplantation', 'Middle Aged', 'Netherlands', 'Patient Selection', 'Pulmonary Fibrosis', 'Retrospective Studies', 'Survival Rate', 'Tissue Donors', 'Waiting Lists'] | 8,710,026 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['C08.381'], ['E04.928.600.495', 'E04.936.450.495'], ['M01.060.116.630'], ['Z01.542.651'], ['E05.581.500.653', 'N04.590.7... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Activation energy determinations suggest that thiols reverse autooxidation of tetrahydrobiopterin by a different mechanism than ascorbate. | In neutral aqueous solutions tetrahydrobiopterin is oxidized by dioxygen in a reaction that is succinctly described as autooxidation. Ascorbate and thiols moderate this reaction by reversing the oxidative process. In the present study the effect of various thiols on the apparent Arrhenius activation energy of tetrahydr... | ['Ascorbic Acid', 'Biopterin', 'Oxidation-Reduction', 'Sulfhydryl Compounds', 'Temperature'] | 16,777,471 | [['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['D03.633.100.733.631.202', 'D08.211.090'], ['G02.700', 'G03.295.531'], ['D02.886.489'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Isolation and preliminary characterization of amino acid substitution mutations that increase the activity of the osmoregulated ProP protein of Salmonella enterica serovar Typhimurium. | In Enterobacteriaceae, the ProP protein, which takes up proline and glycine betaine, is subject to a post-translational control mechanism that increases its activity at high osmolarity. In order to investigate the osmoregulatory mechanism of the Salmonella enterica ProP, we devised a positive selection for mutations th... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Bacterial Proteins', 'Models, Molecular', 'Molecular Sequence Data', 'Mutation, Missense', 'Phenotype', 'Proline', 'Protein Conformation', 'Protein Engineering', 'Salmonella typhimurium', 'Water-Electrolyte Balance'] | 22,360,681 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['D12.776.097'], ['E05.599.595'], ['L01.453.245.667'], ['G05.365.590.650'], ['G05.695'], ['D12.125.072.401.623'], ['G02.111.570.820.709'], ['E05.393.420.601'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['G02.111.6... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Quality of life and eating disorders. | OBJECTIVE: Eating disorders (EDs) can have a serious impact on various life domains and may lead to physical, mental and social impairment and consequently to poor quality of life (QOL). This study compared the QOL of ED patients and former ED patients in a large community based sample to the QOL of a normal reference ... | ['Adult', 'Attitude to Health', 'Feeding and Eating Disorders', 'Female', 'Humans', 'Mood Disorders', 'Netherlands', 'Personal Satisfaction', 'Quality of Life', 'Self Concept', 'Sickness Impact Profile', 'Stress, Psychological', 'Surveys and Questionnaires'] | 16,110,931 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['F03.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.600'], ['Z01.542.651'], ['F01.145.677'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['F01.752.747.792'], ['E05.318.308.980.438.475.730', 'N05.715.360.300.800.438.375.730', 'N06.850.520.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients. | OBJECTIVE: To investigate whether supplementation with fish oil given together with dietary advice and vitamin supplementation influenced the clinical outcome in newly diagnosed multiple sclerosis (MS) patients.MATERIAL AND METHODS: Sixteen consecutive, newly diagnosed patients with multiple sclerosis were recruited to... | ['Acute Disease', 'Adult', 'Diet, Fat-Restricted', 'Fatty Acids, Omega-3', 'Female', 'Humans', 'Male', 'Multiple Sclerosis, Relapsing-Remitting', 'Patient Education as Topic', 'Phospholipids', 'Prospective Studies', 'Secondary Prevention', 'Treatment Outcome', 'Vitamins'] | 10,987,373 | [['C23.550.291.125'], ['M01.060.116'], ['E02.642.249.260', 'G07.203.650.240.260'], ['D10.212.302.380.410', 'D10.251.355.337', 'D10.627.430.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.114.375.500.600', 'C10.314.350.500.600', 'C20.111.258.250.500.600'], ['I02.233.332.500', 'N02.421.726.407.680'], ['D10.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Intraoperative electroencephalographic monitoring during carotid surgery with routine shunting. | Fifty-nine patients undergoing sixty-four carotid reconstructions with routine intraluminal shunting had intraoperative electroencephalographic monitoring. The onset of rhythm or amplitude disturbances was demonstrated in 14 patients during exposure of the carotid artery, and in 24 patients during initial carotid clamp... | ['Aged', 'Anastomosis, Surgical', 'Blood Pressure', 'Brain Ischemia', 'Carotid Arteries', 'Carotid Artery Diseases', 'Electroencephalography', 'Endarterectomy', 'Female', 'Humans', 'Intraoperative Care', 'Intraoperative Complications', 'Male', 'Middle Aged', 'Monitoring, Physiologic'] | 2,364,045 | [['M01.060.116.100'], ['E04.035'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C10.228.140.300.150', 'C14.907.253.092'], ['A07.015.114.186'], ['C10.228.140.300.200', 'C14.907.253.123'], ['E01.370.376.300', 'E01.370.405.245'], ['E04.100.814.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.731.400', 'E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The PEDALS stationary cycling intervention and health-related quality of life in children with cerebral palsy: a randomized controlled trial. | AIM: The aim of this study was to assess health-related quality of life (HRQOL) following a stationary cycling intervention in children with cerebral palsy (CP).METHOD: This was a phase I multisite randomized controlled trial with single blinding. HRQOL was evaluated using the Pediatric Quality of Life Inventory SF15 (... | ['Adolescent', 'California', 'Cerebral Palsy', 'Child', 'Comorbidity', 'Exercise Therapy', 'Female', 'Health Status', 'Humans', 'Male', 'Missouri', 'Motor Skills', 'Quality of Life', 'Severity of Illness Index', 'Treatment Outcome'] | 22,582,760 | [['M01.060.057'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['C10.228.140.140.254'], ['M01.060.406'], ['N05.715.350.225', 'N06.850.490.687'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Structure-activity correlations in human kidney aldehyde reductase-catalyzed reduction of para-substituted benzaldehyde by 3-acetyl pyridine adenine dinucleotide phosphate. | Steady-state kinetic parameters of the human kidney aldehyde reductase-catalyzed reduction of para-substituted benzaldehydes by 3-acetyl pyridine dinucleotide phosphate (3-APADPH) were determined. The kcat of aldehyde reduction by 3-APADPH was 2- to 4-fold lower than by NADPH. The dissociation constant of 3-APADPH from... | ['Alcohol Dehydrogenase', 'Benzaldehydes', 'Catalysis', 'Humans', 'Kidney', 'Kinetics', 'NADP', 'Oxidation-Reduction', 'Structure-Activity Relationship'] | 2,015,291 | [['D08.811.682.047.820.250'], ['D02.047.222'], ['G02.130'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['G01.374.661', 'G02.111.490'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138.749', 'D13.695.827.068.749'], ['G02.700', 'G03.295.531'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hyperdynamic resuscitation improves survival in patients with life-threatening burns. | Our clinical experience has led to the conclusion, shared by others, that standard vital signs produce inadequate data for the resuscitation of severe burns. We reviewed three groups of burn patients including an index group (N = 53) whose resuscitation was guided by means of a pulmonary artery catheter, a control grou... | ['Adult', 'Burns', 'Cardiotonic Agents', 'Catheterization, Swan-Ganz', 'Colloids', 'Fluid Therapy', 'Hemodynamics', 'Humans', 'Resuscitation', 'Survival Rate'] | 9,063,781 | [['M01.060.116'], ['C26.200'], ['D27.505.954.411.222', 'D27.720.799.080'], ['E01.370.370.380.140.210', 'E02.148.224.165', 'E02.148.442.165', 'E04.100.814.529.937.165', 'E04.502.382.937.165', 'E05.157.250.165', 'E05.157.375.165'], ['D20.280', 'D26.255.165'], ['E02.319.360'], ['G09.330.380'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immediate pars plana vitrectomy improves outcome in retained intravitreal lens fragments after phacoemulsification. | PURPOSE: To investigate the clinical features, visual acuity outcomes and the most appropriate intervention time in patients with retained lens fragments managed by pars plana vitrectomy.METHODS: This was a retrospective review of the records of 78 patients who underwent pars plana vitrectomy for retained lens fragment... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Follow-Up Studies', 'Humans', 'Lens Subluxation', 'Male', 'Middle Aged', 'Phacoemulsification', 'Retrospective Studies', 'Risk Factors', 'Time Factors', 'Treatment Outcome', 'Visual Acuity', 'Vitrectomy'] | 18,560,248 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.510.598'], ['M01.060.116.630'], ['E04.540.825.249.704', 'E04.943.875'], ['E05.318.372.500.500.500', 'E05.318.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
How to Map Theory: Reliable Methods Are Fruitless Without Rigorous Theory. | Good science requires both reliable methods and rigorous theory. Theory allows us to build a unified structure of knowledge, to connect the dots of individual studies and reveal the bigger picture. Some have criticized the proliferation of pet "Theories," but generic "theory" is essential to healthy science, because qu... | ['Cognition', 'Decision Making', 'Humans', 'Judgment', 'Knowledge', 'Morals', 'Psychological Theory', 'Thinking'] | 28,873,328 | [['F02.463.188'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['K01.468'], ['F01.829.500', 'K01.752.566'], ['F02.739'], ['F02.463.785']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy. | It has been suggested that the phosphodiesterase-5 (PDE5) inhibitor sildenafil may be useful in the treatment of hypertension during pregnancy. However, we have reported a selective increase in renal inner medullary PDE5 that participates in the sodium retention of pregnancy. Therefore, the purpose of this study was to... | ['Animals', 'Blood Pressure', 'Creatinine', 'Cyclic Nucleotide Phosphodiesterases, Type 5', 'Female', 'Fetal Development', 'Fetus', 'Hematocrit', 'Hemodynamics', 'Phosphodiesterase 5 Inhibitors', 'Phosphodiesterase Inhibitors', 'Piperazines', 'Plasma Volume', 'Pregnancy', 'Pregnancy, Animal', 'Purines', 'Rats', 'Rats, ... | 19,955,496 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.383.129.308.207'], ['D08.811.277.352.640.150.500', 'D08.811.277.352.640.155.500', 'D12.644.360.008.500', 'D12.644.360.009.500', 'D12.776.476.008.500', 'D12.776.476.009.500'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['A16.378'], ['E01.370.225.625.40... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo evaluation of [11C]- and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. | Four analogues of the potent dopamine transporter ligand, WIN 35,428, were radiolabelled with 11C and 18F at the 2-beta-carboxy position for evaluation as potential ligands for imaging dopamine uptake sites by positron emission tomography (PET) namely, methyl (1R-2-exo-3-exo)-8- methyl-3-(4-methylphenyl)-8-azabicyclo[3... | ['Animals', 'Carbon Radioisotopes', 'Carrier Proteins', 'Cocaine', 'Dopamine Plasma Membrane Transport Proteins', 'Fluorine Radioisotopes', 'Injections, Intravenous', 'Ligands', 'Male', 'Membrane Glycoproteins', 'Membrane Transport Proteins', 'Nerve Tissue Proteins', 'Rats', 'Rats, Sprague-Dawley', 'Tissue Distribution... | 8,868,286 | [['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['D12.776.157'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['D12.776.157.530.450.625.124', 'D12.776.157.530.562.374.500.500', 'D12.776.157.530.937.500', 'D12.776.543.585.450.625.124', 'D12.776.54... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ICTV Virus Taxonomy Profile: Partitiviridae. | The Partitiviridae is a family of small, isometric, non-enveloped viruses with bisegmented double-stranded (ds) RNA genomes of 3-4.8 kbp. The two genome segments are individually encapsidated. The family has five genera, with characteristic hosts for members of each genus: either plants or fungi for genera Alphapartiti... | ['Alveolata', 'Fungi', 'Genome, Viral', 'Phylogeny', 'Plants', 'RNA Viruses', 'RNA, Viral', 'Terminology as Topic', 'Virion', 'Virus Replication'] | 29,214,972 | [['B01.043'], ['B01.300'], ['G05.360.340.358.840'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.650'], ['B04.820'], ['D13.444.735.828'], ['L01.559.598.400'], ['A21.249'], ['G06.920.925']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. | An optimally effective AIDS vaccine would likely require the induction of both neutralizing antibody and cell-mediated immune responses, which has proven difficult to obtain in previous clinical trials. Here we report on the induction of Human Immunodeficiency Virus Type-1 (HIV-1)-specific immune responses in healthy a... | ['AIDS Vaccines', 'Adolescent', 'Adult', 'HIV Antibodies', 'HIV Envelope Protein gp120', 'Human Experimentation', 'Humans', 'Immunoglobulin G', 'Interferon-gamma', 'Middle Aged', 'Neutralization Tests', 'T-Lymphocytes', 'Vaccines, DNA'] | 18,243,434 | [['D20.215.894.899.050'], ['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.254.150.440', 'D12.776.124.790.651.114.254.150.440', 'D12.776.377.715.548.114.254.150.440'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.520.350'], ['E05.445', 'H01.77... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
A liquor contacting area in the pineal recess of the golden hamster (Mesocricetus auratus). | The wall of the third ventricle in the pineal recess of the golden hamster (Mesocricetus auratus) has been investigated by light and electron microscopy. Deep in the pineal recess, where the ependymal lining is thin and non-ciliated, clusters of pinealocytes protrude into the ventricular lumen. They force the ependyma ... | ['Animals', 'Cerebral Ventricles', 'Cerebrospinal Fluid', 'Cricetinae', 'Ependyma', 'Male', 'Melatonin', 'Mesocricetus', 'Microscopy, Electron', 'Pineal Gland'] | 677,476 | [['B01.050'], ['A08.186.211.140'], ['A12.207.270.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['A08.186.211.140.460', 'A10.755.260'], ['D03.633.100.473.914.481', 'D06.472.506'], ['B01.050.150.900.649.313.992.635.075.250.500'], ['E01.370.350.515.402', 'E05.595.402'], ['A06.300.635', 'A06.688.733', 'A08.186.211.18... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Incidence of microcracks in maxillary first premolars after instrumentation with three different mechanized file systems: a comparative ex vivo study. | OBJECTIVES: The objective of this study is to determine the potential for microcracks in the radicular dentin of first maxillary premolars using three different mechanized endodontic instrumentation systems.METHODS: Eighty extracted maxillary first premolars with two root canals and no externally visible microcracks we... | ['Bicuspid', 'Dental Instruments', 'Equipment Design', 'Humans', 'In Vitro Techniques', 'Maxilla', 'Root Canal Preparation'] | 27,025,212 | [['A14.549.167.860.150'], ['E06.186.501', 'E07.222.501'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A02.835.232.781.324.502.645', 'A14.521.645'], ['E06.397.778.889', 'E06.931.625']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterisation of the water-isopropyl myristate system. | Partition coefficients for compounds (solutes) from water to isopropyl myristate, IPM, have been obtained from the literature, either as directly determined partition coefficients or from solubilities in water and in IPM. The general solvation equation of Abraham has been applied to 141 such partition coefficients, as ... | ['Epidermis', 'Humans', 'Myristates', 'Water'] | 15,814,236 | [['A10.272.497', 'A17.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.251.640.610'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The influence of the host cell on standardisation of influenza vaccine potency. | Conventional influenza vaccines are standardised using the single-radial-immunodiffusion (SRD) test where reagents are produced from egg-grown viruses. It is important to ensure homology between SRD antigen reagents and test vaccines. There was concern that cell-grown vaccines may differ antigenically from correspondin... | ['Animals', 'Antigens, Viral', 'Cell Line', 'Chick Embryo', 'Dogs', 'Humans', 'Immunodiffusion', 'Influenza A virus', 'Influenza Vaccines', 'Radioimmunoassay', 'Virus Cultivation'] | 10,494,972 | [['B01.050'], ['D23.050.327'], ['A11.251.210'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.735.645.350', 'E05.200.812.735.645.350', 'E05.478.594.760.645.350', 'E05.478.605.492.350'], ['B04.820.480.968.405.400'], ['D20.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Brachybacterium saurashtrense sp. nov., a halotolerant root-associated bacterium with plant growth-promoting potential. | A Gram-positive-staining, aerobic, non-motile, coccoid shaped, halotolerant bacterium (strain JG 06(T)) was isolated from the roots of Salicornia brachiata, an extreme halophyte. Phylogenetic analysis based on 16S rRNA gene sequence showed that the novel strain had sequence similarities of 99.2% to Brachybacterium para... | ['Actinomycetales', 'Base Composition', 'Chenopodiaceae', 'DNA, Bacterial', 'DNA, Ribosomal', 'Fatty Acids', 'Molecular Sequence Data', 'Phylogeny', 'Plant Roots', 'RNA, Ribosomal, 16S', 'Sodium Chloride'] | 21,216,918 | [['B03.510.024.049'], ['G02.111.080'], ['B01.650.940.800.575.912.250.200'], ['D13.444.308.212'], ['D13.444.308.475'], ['D10.251'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['A18.400'], ['D13.444.735.686.670'], ['D01.210.450.150.875', 'D01.857.650']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A study of sensory recovery following carpal tunnel release. | The purpose of this study was to define the testing parameters that are most sensitive to sensory loss in carpal tunnel syndrome and then to track recovery of these sensations postoperatively. Two dozen patients underwent standard nerve decompression and were subsequently re-evaluated at six weeks, three months, and si... | ['Adult', 'Aged', 'Carpal Tunnel Syndrome', 'Discrimination, Psychological', 'Female', 'Hand', 'Humans', 'Male', 'Middle Aged', 'Neurologic Examination', 'Sensation', 'Sensory Thresholds', 'Thermosensing', 'Touch', 'Vibration'] | 8,343,878 | [['M01.060.116'], ['M01.060.116.100'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['F02.463.593.257'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.376.550', 'E01.370.600.550'], ['F02.830.816', 'G11.561.790'], ['F02.463.593.710'], ['F02... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. | CONTEXT: Leptin deficiency is associated with dyslipidemia and insulin resistance in animals and humans with lipoatrophy; leptin replacement ameliorates these abnormalities.OBJECTIVE: The objective of the study was to evaluate the effects of leptin therapy in lipoatrophic HIV-infected patients with dyslipidemia and hyp... | ['Adipose Tissue', 'Adult', 'Body Composition', 'Cholesterol', 'HIV Infections', 'Humans', 'Leptin', 'Lipodystrophy', 'Middle Aged', 'Oxygen Consumption', 'Recombinant Proteins', 'Triglycerides', 'Viscera'] | 19,174,500 | [['A10.165.114'], ['M01.060.116'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Success of medical therapy in a rare case of cecal ameboma. | INTRODUCTION: Colitis caused by Entamoeba histolytica (EH) is prevalent in developing countries. Clinical presentation ranges from mild diarrhoea episodes to dysentery and liver abscess. Ameboma, a complication caused by EH invasion of the intestinal wall, is a rare presentation of amebiasis, occurring approximately in... | ['Amebiasis', 'Cecal Diseases', 'Female', 'Humans', 'Middle Aged', 'Remission Induction'] | 21,592,907 | [['C01.610.752.049'], ['C06.405.469.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.860']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pre-operative localization of aldosterone-secreting adrenal adenomas. | Techniques for pro-operative localization of aldosterone-secreting adrenal adenomas were studied in thirty-seven patients, each with hypertension and biochemical evidence of primary hyperaldosteronism and each later having adrenal surgery (thirty-two adenomas, five bilateral hyperplasia). Bilateral adrenal vein cathete... | ['Adenoma', 'Adrenal Gland Neoplasms', 'Adrenal Glands', 'Adult', 'Aged', 'Aldosterone', 'Catheterization', 'Female', 'Humans', 'Hyperplasia', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 7,326,851 | [['C04.557.470.035'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['A06.300.071'], ['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['E02.148', 'E05.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['M01.060.116.630'], ['E01.370.350.350.810... | ['Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine. | Carbofuran, a widely used carbamate pesticide, has been reported to cause neurotoxicity. However, the underlying mechanisms involved in carbofuran neurotoxicity are not well understood. The present study was envisaged to investigate the possible role of oxidative stress in carbofuran neurotoxicity and to evaluate the p... | ['Acetylcholinesterase', 'Acetylcysteine', 'Analysis of Variance', 'Animals', 'Avoidance Learning', 'Behavior, Animal', 'Brain', 'Brain Chemistry', 'Carbofuran', 'Cholinesterase Inhibitors', 'Drug Interactions', 'Free Radical Scavengers', 'Glutathione', 'Lipid Peroxidation', 'Male', 'Rats', 'Rats, Wistar', 'Rotarod Per... | 16,307,259 | [['D08.811.277.352.100.170.176'], ['D02.886.030.230.259', 'D12.125.166.230.259'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.113'], ['A08.186.211'], ['G02.111.150', 'G03.185'], ['D02.241.081.251.583.166'], ['D27.505.519.389.275',... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Immunofluorescence staining. | This unit provides a protocol for indirect immunofluorescence, which is a method that provides information about the locations of specific molecules and the structure of the cell. Antibody molecules for a specific target molecule are exposed to the cell or tissue being investigated. The binding of these molecules is de... | ['Animals', 'Antigen-Antibody Reactions', 'Cells, Cultured', 'Fluorescent Antibody Technique, Indirect', 'Fluorescent Dyes', 'Indicators and Reagents', 'Microscopy, Fluorescence', 'Specimen Handling', 'Staining and Labeling', 'Tissue Fixation'] | 18,228,363 | [['B01.050'], ['G12.122'], ['A11.251'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.607.512.240.310', 'E05.200.750.551.512.240.310', 'E05.478.583.375.310'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D27.720.470.410'], ['E01.370.350.515.458', 'E05.595.458'], ['E01.370.225.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrochemical screening of anti-microbial peptide LL-37 interaction with phospholipids. | LL-37 is an alpha-helical antimicrobial peptide of human origin. It is a 37 residue cathelicidin peptide. This paper explores the use of electrochemical methods to investigate the interaction of LL-37 with phospholipid and lipid A monolayers on a mercury drop electrode. Experiments were carried out in Dulbecco's phosph... | ['Antimicrobial Cationic Peptides', 'Electric Impedance', 'Electrochemistry', 'Lipid Bilayers', 'Materials Testing', 'Phospholipids', 'Porosity', 'Spectrum Analysis'] | 16,949,887 | [['D12.644.050', 'D12.776.543.695.054'], ['G01.358.500.249.277.350'], ['H01.181.529.307'], ['D10.570.510', 'J01.637.087.500.510'], ['E05.570'], ['D10.570.755'], ['G01.374.710'], ['E05.196.867']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Reconstitution of carotenoids into the light-harvesting complex B800-850 of Chromatium minutissimum. | Chromatophores and peripheral light-harvesting complexes B800-850 with a trace of carotenoids were isolated from Chromatium minutissimum cells in which carotenoid biosynthesis was inhibited by diphenylamine. Three methods previously used for the reconstitution of carotenoids into either the light-harvesting (LH1) type ... | ['Bacterial Proteins', 'Carotenoids', 'Chromatium', 'Chromatography, High Pressure Liquid', 'Diphenylamine', 'Mutation', 'Photosynthetic Reaction Center Complex Proteins'] | 12,948,391 | [['D12.776.097'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['B03.440.425.410.290', 'B03.660.250.110.150'], ['E05.196.181.400.300'], ['D02.092.146.350'], ['G05.365.590'], ['D05.500.562.488', 'D08.811.600.710', 'D12.776.543.930.500', 'D12.776.765.199.750.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genomic and transcriptome analysis of triclosan response of a multidrug-resistant Acinetobacter baumannii strain, MDR-ZJ06. | During the last decade, an increasing amount of attention has focused on the potential threat of triclosan to both the human body and environmental ecology. However, the role of triclosan in the development of drug resistance and cross resistance is still in dispute ascribed to largely unknown of triclosan resistance m... | ['Acinetobacter baumannii', 'Anti-Bacterial Agents', 'Drug Resistance, Multiple, Bacterial', 'Gene Expression Profiling', 'Genome, Bacterial', 'Genomics', 'Triclosan'] | 27,665,456 | [['B03.440.400.425.537.050.099', 'B03.660.250.530.050.099'], ['D27.505.954.122.085'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['E05.393.332'], ['G05.360.340.358.207'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['D02.355.726.900', 'D02.455.426.559.389.657.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity. | Several in vitro and in vivo studies have demonstrated suppression of tumour necrosis factor-alpha (TNF-alpha) synthesis by pentoxifylline. In the present study we compared the effect of pentoxifylline with that of five other xanthine derivatives. We addressed two questions. First, what is the relative potency of those... | ["3',5'-Cyclic-AMP Phosphodiesterases", 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Humans', 'Pentoxifylline', 'Theophylline', 'Tumor Necrosis Factor-alpha', 'Xanthines'] | 8,388,363 | [['D08.811.277.352.640.150', 'D12.644.360.008', 'D12.776.476.008'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.759.758.824.651.700'], ['D03.132.960.751', 'D03.633.100.759.758.824.751'], ['D12.644.276.374.500.800', 'D12.644.276.374.750.626', 'D12.7... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A voltage-clamp study of calcium currents in neurons freshly isolated from the dorsal root ganglion of adult rats. | Calcium currents were studied in a preparation of freshly isolated neurons of the dorsal root ganglion (DRG) of adult rats using the whole-cell voltage-clamp technique in conditions of minimal current flow through sodium and potassium channels. A low-threshold (LT) and a high-threshold (HT) current were distinguished o... | ['Animals', 'Cadmium', 'Calcium Channels', 'Electric Conductivity', 'Flunarizine', 'Ganglia, Spinal', 'Kinetics', 'Neurons', 'Nifedipine', 'Potassium Channels', 'Rats', 'Rats, Wistar', 'Sodium Channels'] | 7,508,292 | [['B01.050'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['G01.358.500.249.277'], ['D03.383.606.450'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G01.374.661', 'G02.111.490'], ['A08.675', 'A11.67... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nanotube surfactant design: the versatility of water-soluble perylene bisimides. | The synthesis of perylene-based single-walled carbon nanotube (SWCNT) surfactants and the dispersion and exfoliation of SWCNTs in water by a variety of designed surfactants is investigated. The quality of the nanotube dispersions is evaluated by optical absorption and emission spectroscopy, zeta-potential measurements ... | ['Imides', 'Microscopy, Atomic Force', 'Nanotubes, Carbon', 'Perylene', 'Spectrophotometry, Ultraviolet', 'Spectroscopy, Near-Infrared', 'Surface-Active Agents', 'Water'] | 20,217,789 | [['D02.478'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['D02.455.426.559.847.149.700', 'D02.455.426.559.847.680.500', 'D04.615.149.700', 'D04.615.680.500'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['E01.370.350.750', 'E05.196.867.851'], ['D27.720.877'], ['D... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effects of different phosphoric acid concentrations on surface enamel. | The purpose of this study was to evaluate the effects of different acid concentrations on the enamel surface morphology. The buccal surfaces of 25 extracted premolars from young patients were etched with 40%, 20%, 10%, 5%, and 2% phosphoric acid solutions for 60 seconds. The specimens were examined with a scanning elec... | ['Acid Etching, Dental', 'Adolescent', 'Child', 'Dental Enamel', 'Dental Enamel Solubility', 'Humans', 'Microscopy, Electron, Scanning', 'Phosphoric Acids', 'Time Factors'] | 1,554,164 | [['E06.931.475.111'], ['M01.060.057'], ['M01.060.406'], ['A14.549.167.900.255'], ['G10.549.181'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D01.029.260.700.675', 'D01.695.625.675'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Conceptual views on quality of life. | Quality of life can be discussed in many ways. One way is to analyse the empirical quantitative approach to determine whether the research categories are operational, empirically unambiguous, and thematically relevant; progress, in the sense of changing the number of research categories, does not take place through a s... | ['Adaptation, Psychological', 'Choice Behavior', 'Humanism', 'Humans', 'Neoplasms', 'Quality of Life', 'Research Design', 'Science'] | 1,514,971 | [['F01.058'], ['F02.463.785.373.346'], ['K01.752.566.479.174', 'N05.350.835'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.581.500', 'H01.770.644.728'], ['H01.770']] | ['Psychiatry and Psychology [F]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Current use of preoperative intra-aortic balloon counterpulsation in high-risk cardiac surgery: a cohort study. | OBJECTIVE: To determine whether preoperative introduction of intra-aortic balloon counterpulsation (IABC) reduced mortality in high-risk patients undergoing coronary artery bypass graft (CABG) surgery.METHODS: This was a retrospective cohort study of prospectively collected data on all patients who underwent cardiac su... | ['Aged', 'Coronary Artery Bypass', 'Female', 'Humans', 'Intra-Aortic Balloon Pumping', 'Length of Stay', 'Male', 'New South Wales', 'Postoperative Complications', 'Preoperative Care', 'Regression Analysis', 'Retrospective Studies', 'Risk Factors'] | 18,798,716 | [['M01.060.116.100'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.050.215.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['C23.550.767'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Personality dysfunction in adults who stutter: another look. | PURPOSE: Given reports of the frequent occurrence of personality disorders (PD) among individuals who stutter, this investigation was designed to determine the presence of personality disorders (PD) for individuals seeking treatment for stuttering, using a different self-report measure.METHOD: The sample included 50 ad... | ['Adolescent', 'Adult', 'Aged', 'Comorbidity', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personality', 'Personality Disorders', 'Personality Inventory', 'Self Report', 'Stuttering', 'Young Adult'] | 23,773,670 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N05.715.350.225', 'N06.850.490.687'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.752'], ['F03.675'], ['F04.711.647.513'], ['E05.318.308.980.500', 'N05.715.360.300.800.500', 'N06.850.520.308.980.500'], ['C10.597.606.150.500.800.75... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptional Response of Multiple ESBL Genes Within Escherichia coli Under Oxyimino-Cephalosporin Stress. | The expression of extended-spectrum beta-lactamases directly interferes with the treatment options in a clinical setting. It is not clearly defined why bacteria acquire multiple beta-lactamases and how they are being expressed in antibiotic stress. With this key question, the study was designed to understand the transc... | ['Adult', 'Aged', 'Anti-Bacterial Agents', 'Ceftazidime', 'Cephalosporins', 'Escherichia coli', 'Escherichia coli Infections', 'Escherichia coli Proteins', 'Female', 'Humans', 'Male', 'Microbial Sensitivity Tests', 'Middle Aged', 'Plasmids', 'Real-Time Polymerase Chain Reaction', 'Transcription, Genetic', 'beta-Lactama... | 27,214,038 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['D02.065.589.099.249.210.150', 'D02.886.665.074.210.150', 'D03.633.100.300.249.210.150'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['D12.776.097... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans. | We hypothesized that a short-term training program involving repeated all-out sprint training (RST) would be more effective than work-matched, low-intensity endurance training (ET) in enhancing the kinetics of oxygen uptake (Vo(2)) and muscle deoxygenation {deoxyhemoglobin concentration ([HHb])} following the onset of ... | ['Adaptation, Physiological', 'Bicycling', 'Exercise', 'Exercise Test', 'Female', 'Hemoglobins', 'Humans', 'Lung', 'Male', 'Muscle, Skeletal', 'Oxygen', 'Oxygen Consumption', 'Spectroscopy, Near-Infrared', 'Young Adult'] | 19,342,439 | [['G07.025', 'G16.012.500'], ['I03.450.642.845.140'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['A02.633.567', 'A10.690.552.500'], ['D01.268.185.550', 'D01.... | ['Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Prophylactic oophorectomy in the treatment of carcinoma of the breast. | Several prospective clinical trials have been conducted to investigate the efficacy of prophylactic ovarium ablation in the primary treatment of carcinoma of the breast. The results have varied and the follow-up periods have been rather short. A prospective randomized study was done at our institution from 1961 to 1966... | ['Adult', 'Aged', 'Breast Neoplasms', 'Carcinoma', 'Clinical Trials as Topic', 'Female', 'Follow-Up Studies', 'Humans', 'Lymph Node Excision', 'Mastectomy', 'Menopause', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Ovariectomy', 'Prospective Studies', 'Random Allocation'] | 3,513,347 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Big or small, room for all. | In today's world of high demand, nurses have more of an opportunity than ever to get just what they want. Nurses find rewards in what they do no matter where they work. SH profiles nurses from two Texas hospitals. | ['Career Choice', 'Health Facility Size', 'Job Satisfaction', 'Nursing Staff, Hospital', 'Personnel Selection', 'Salaries and Fringe Benefits', 'Texas'] | 10,114,754 | [['F02.463.785.373.346.400'], ['N02.278.306', 'N05.300.430.410'], ['F02.784.692.425'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['N04.452.677.500'], ['N01.824.417.700', 'N04.452.677.800'], ['Z01.107.567.875.760.750']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ministers' perceptions of church-based programs to provide depression care for African Americans. | African Americans, compared with white Americans, underutilize mental health services for major depressive disorder. Church-based programs are effective in reducing racial disparities in health; however, the literature on church-based programs for depression is limited. The purpose of this study was to explore minister... | ['African Americans', 'Depressive Disorder, Major', 'Female', 'Focus Groups', 'Humans', 'Male', 'Mental Health Services', 'Middle Aged', 'New York City', 'Professional Role', 'Protestantism', 'Psychotherapy', 'Religion and Psychology'] | 23,471,573 | [['M01.686.508.100.100', 'M01.686.754.100'], ['F03.600.300.375'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.408', 'N02.421.461'], ['M01.060.116.630'], ['Z01.107.567.875.350.530.530', 'Z01.107.567.875.500.530.530', 'Z01.433.741'], ['F01.829.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The randomized fast-track trial in palliative care: role, utility and ethics in the evaluation of interventions in palliative care? | BACKGROUND: Randomized trials are the gold standard method for evaluating treatments and services in health care. However, they are often difficult to complete in palliative care, and suffer from poor recruitment.AIM: To introduce the randomized fast-track trial and its potential use in palliative care.METHOD: The rand... | ['Data Collection', 'Evaluation Studies as Topic', 'Humans', 'Multiple Sclerosis', 'Palliative Care', 'Randomized Controlled Trials as Topic', 'Research Design', 'Waiting Lists', 'Workforce'] | 21,993,806 | [['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['E02.760.666', 'N02.421.585.666'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Comparison of an auto-stereoscopic display and polarized stereoscopic projection for macroscopic pathology. | We investigated stereoscopic imaging for gross examination in telepathology. A conventional macroscopic station was equipped with two cameras mounted 6.5 cm apart and images were produced of 30 different routine pathology specimens. Still images were displayed on a three-dimensional auto-stereoscopic display with a len... | ['Automation', 'Equipment Design', 'Humans', 'Image Processing, Computer-Assisted', 'Pathology'] | 15,273,030 | [['J01.897.104'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['H02.403.650']] | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Perceptions of Hospital-Dependent Patients on Their Needs for Hospitalization. | In the United States, older adults account for a significant proportion of hospitalizations, and a subset become hospital-dependent, for reasons that are unclear. We conducted a qualitative study to explore these individuals' perspectives on their need for hospitalizations. Twenty patients hospitalized at an academic m... | ['Aged', 'Aged, 80 and over', 'Female', 'Health Services Needs and Demand', 'Hospitalization', 'Humans', 'Male', 'Patient Satisfaction', 'Perception'] | 28,574,536 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['N03.349.380.420', 'N05.300.450'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['F02.463.593']] | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation. | We assessed the effect of early-onset exercise as a means of preventing childhood obesity using juvenile male rats selectively bred to develop diet-induced obesity (DIO) or to be diet resistant (DR) when fed a 31% fat high-energy diet. Voluntary wheel running begun at 36 days of age selectively reduced adiposity in DIO... | ['Adipose Tissue', 'Animal Feed', 'Animals', 'Body Weight', 'Brain-Derived Neurotrophic Factor', 'Caloric Restriction', 'Eating', 'Hypothalamus', 'Insulin', 'Leptin', 'Male', 'Neuropeptide Y', 'Obesity', 'Physical Conditioning, Animal', 'Pro-Opiomelanocortin', 'RNA, Messenger', 'Rats', 'Rats, Inbred Strains', 'Receptor... | 17,989,137 | [['A10.165.114'], ['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['E02.642.249.200', 'G07.203.650.240.3... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Identification of mimotopes by screening of a bacterially displayed random peptide library and its use in eliciting an immune response to native HBV-preS. | Bacterially-displayed peptide libraries have been widely used as an alternative to phage-displayed peptide libraries in screening epitopes or mimotopes of antibodies. Using a protective monoclonal antibody (mAb) 3B9 against hepatitis B virus (HBV) preS protein as target, mimotopes were successfully screened from a FliT... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Viral', 'Blotting, Western', 'Cloning, Molecular', 'DNA', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Female', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Mice', 'Mice, Inbred BALB C', 'Peptide Library', 'Protein Precursors'] | 14,505,920 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.393.220']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Restenosis after transluminal coronary angioplasty detected with exercise-gated radionuclide ventriculography. | Forty-one patients were evaluated with exercise-gated radionuclide ventriculography before and within 4 days after successful transluminal coronary angioplasty and 4 to 12 months later. Patients were subgrouped according to the degree of restenosis demonstrated angiographically at 4 to 12 months (Group I [n = 23]: less... | ['Aged', 'Angioplasty, Balloon', 'Constriction, Pathologic', 'Coronary Disease', 'Coronary Vessels', 'Female', 'Follow-Up Studies', 'Heart', 'Humans', 'Male', 'Middle Aged', 'Physical Exertion', 'Radionuclide Imaging', 'Recurrence', 'Sodium Pertechnetate Tc 99m', 'Stroke Volume', 'Time Factors'] | 6,094,635 | [['M01.060.116.100'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['C23.300.287'], ['C14.280.647.250', 'C14.907.585.250'], ['A07.015.114.269', 'A07.015.908.194'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A07.541'], ['B01.0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of Block Copolymerization on the Antifreeze Protein Mimetic Ice Recrystallization Inhibition Activity of Poly(vinyl alcohol). | Antifreeze (glyco) proteins are produced by many cold-acclimatized species to enable them to survive subzero temperatures. These proteins have multiple macroscopic effects on ice crystal growth which makes them appealing for low-temperature applications-from cellular cryopreservation to food storage. Poly(vinyl alcohol... | ['Antifreeze Proteins', 'Biomimetic Materials', 'Cryoprotective Agents', 'Crystallization', 'Hydrophobic and Hydrophilic Interactions', 'Ice', 'Polymerization', 'Polyvinyl Alcohol'] | 27,476,873 | [['D12.776.053'], ['J01.637.087'], ['D27.505.696.706.320', 'D27.720.799.180'], ['E05.196.300', 'G02.171'], ['G02.409'], ['D01.045.250.875.400', 'D01.248.497.158.459.650.400', 'D01.650.550.925.400', 'G16.500.275.410', 'G16.500.750.775.342', 'N06.230.291'], ['G02.750'], ['D02.033.750', 'D02.455.326.271.884.533.532', 'D05... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. | Few population-based case-control studies have assessed etiologic factors for penile cancer. Past infection with high-risk human papillomavirus (HPV) is a known risk factor for penile cancer; however, few previous studies have related the HPV DNA status of the tumor to potential demographic and behavioral risk factors ... | ['Adolescent', 'Adult', 'Aged', 'Case-Control Studies', 'Circumcision, Male', 'DNA, Viral', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Papillomavirus Infections', 'Penile Neoplasms', 'Phimosis', 'Risk Factors', 'Smoking'] | 15,825,185 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E02.218.085.170', 'E04.085.170', 'E04.950.774.860.226'], ['D13.444.308.568'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
How--and why--to request an autopsy. | Autopsy remains the touch-stone of diagnosis, but clinicians are often reluctant to request the procedure because of their discomfort in approaching the family. Fundamental to a successful autopsy request is sensitivity for the family's feelings, which bespeaks respect for the deceased and the family. For example, in a... | ['Autopsy', 'Communication', 'Death', 'Family', 'Informed Consent', 'Mortuary Practice', 'Professional-Family Relations'] | 3,975,184 | [['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['F01.145.209', 'L01.143'], ['C23.550.260'], ['F01.829.263', 'I01.880.853.150'], ['I01.880.604.473.650.718', 'I01.880.604.583.427', 'N03.706.437.650.312', 'N03.706.535.489'], ['H02.438'], ['F01.829.401.550']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications. | Acetate, together with other short chain fatty acids has been implicated in colorectal cancer (CRC) prevention/therapy. Acetate was shown to induce apoptosis in CRC cells. The precise mechanism underlying acetate transport across CRC cells membrane, that may be implicated in its selectivity towards CRC cells, is not fu... | ['Acetates', 'Biological Transport', 'Cell Line, Tumor', 'Colorectal Neoplasms', 'Glycolysis', 'Humans', 'Monocarboxylic Acid Transporters', 'Muscle Proteins', 'Pyruvates', 'Symporters'] | 28,874,966 | [['D02.241.081.018', 'D10.251.400.045'], ['G03.143'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['B01.050.150.90... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Performance of the Hemoccult test in the screening of colorectal cancer and adenoma. Results of 5 screening campaigns in Sa?ne-et-Loire]. | OBJECTIVES: The aim of this population-based study was to specify the positivity rate, the positive predictive value of Hemoccult test as well as the characteristics of the cancers and adenomas screened during the successive colorectal cancer screening campaigns.METHODS: This study focused on five colorectal cancer mas... | ['Adenoma', 'Aged', 'Aged, 80 and over', 'Colorectal Neoplasms', 'Female', 'France', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Occult Blood', 'Predictive Value of Tests', 'Retrospective Studies'] | 10,429,850 | [['C04.557.470.035'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580',... | ['Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Social and racial inequalities in preterm births in Western Australia, 1984 to 2006. | Preterm birth is associated with a range of childhood morbidities and in industrialised societies is the primary cause of infant mortality. Social and racial inequalities in preterm birth have been reported in North America, UK, Europe and New Zealand. This study utilised population-level data to investigate social and... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Infant, Newborn', 'Logistic Models', 'Male', 'Middle Aged', 'Oceanic Ancestry Group', 'Population Surveillance', 'Premature Birth', 'Prevalence', 'Socioeconomic Factors', 'Western Australia', 'Young Adult'] | 20,618,725 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525', 'N06.850.5... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. | DegS is a periplasmic Escherichia coli protease, which functions as a trimer to catalyze the initial rate-limiting step in a proteolytic cascade that ultimately activates transcription of stress response genes in the cytoplasm. Each DegS subunit consists of a protease domain and a PDZ domain. During protein folding str... | ['Allosteric Site', 'Bacterial Proteins', 'Crystallography, X-Ray', 'Dimerization', 'Escherichia coli', 'Escherichia coli Proteins', 'Gene Expression Regulation, Bacterial', 'Hydrogen Bonding', 'Kinetics', 'Mutation', 'Protein Binding', 'Protein Folding', 'Protein Structure, Tertiary'] | 20,739,286 | [['G02.111.570.120.147'], ['D12.776.097'], ['E05.196.309.742.225'], ['G02.206', 'G03.230'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G05.308.300'], ['G02.282'], ['G01.374.661', 'G02.111.490'], ['G05.365.590'], ['G02.111.679', 'G03.808'], ['G01.154.651', 'G02.111.688'], ['G02.111.57... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property. | Most reported carbazolyl G-quadruplex DNA (G4-DNA) ligands possess a rigid structure rather than a flexible one. The conformationally flexible ligands are paid much less attention. In this study, we report a novel class of non-rigid methylene-bridged biscarbazolyl ligand and their G4-DNA binding properties. Moreover, t... | ['Antineoplastic Agents', 'Apoptosis', 'Carbazoles', 'Cell Proliferation', 'DNA', 'G-Quadruplexes', 'Humans', 'Ligands', 'Neoplasms', 'Structure-Activity Relationship', 'Tumor Cells, Cultured'] | 31,255,989 | [['D27.505.954.248'], ['G04.146.954.035'], ['D03.633.100.473.144', 'D03.633.300.148'], ['G04.161.750', 'G07.345.249.410.750'], ['D13.444.308'], ['G02.111.570.820.486.550', 'G05.360.580.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['C04'], ['G02.111.830', 'G07.690.773.997'], ['A11.251.860... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating â-catenin. | Despite a lack of mutations, accumulating evidence supports an important role for the Wnt/â-catenin pathway in ovarian tumorigenesis. However, the molecular mechanism that contributes to the aberrant activation of the Wnt signaling cascade in ovarian cancer has not been fully elucidated. Here, we found that protein tyr... | ['Animals', 'Cell Line', 'Cell Line, Tumor', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'HEK293 Cells', 'Humans', 'Mice, Nude', 'Ovarian Neoplasms', 'Phosphorylation', 'RNA Interference', 'RNAi Therapeutics', 'Receptor-Like Protein Tyrosine Phosphatases, Class 7', 'Survival Analysi... | 31,653,698 | [['B01.050'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.393.332'], ['G05.308.370'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C1... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. | Cell division is controlled through cooperation of different kinases. Of these, polo-like kinase 1 (Plk1) and p90 ribosomal S6 kinase 1 (RSK1) play key roles. Plk1 acts as a G(2)/M trigger, and RSK1 promotes G(1) progression. Although previous reports show that Plk1 is suppressed by RSK1 during meiosis in Xenopus oocyt... | ['Amino Acid Sequence', 'Animals', 'Artemia', 'Aurora Kinases', 'Base Sequence', 'Blotting, Western', 'Cell Cycle Checkpoints', 'Cell Cycle Proteins', 'Extracellular Signal-Regulated MAP Kinases', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Enzymologic', 'HeLa Cells', 'Humans', 'Mitogen-Ac... | 22,427,657 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.500.131.365.060.050'], ['D08.811.913.696.620.682.700.103', 'D12.776.167.049'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.144.109... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Discovery and Characterization of Cyclotides from Rinorea Species. | Cyclotides are macrocyclic cystine-knotted peptides most commonly found in the Violaceae plant family. Although Rinorea is the second-largest genera within the Violaceae family, few studies have examined whether or not they contain cyclotides. To further our understanding of cyclotide diversity and evolution, we examin... | ['Amino Acid Sequence', 'Chromatography, High Pressure Liquid', 'Cyclotides', 'Plant Extracts', 'Sequence Homology, Amino Acid', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem Mass Spectrometry', 'Violaceae'] | 30,387,611 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.181.400.300'], ['D12.644.641.243'], ['D20.215.784.500', 'D26.667'], ['G02.111.810.200', 'G05.810.200'], ['E05.196.566.600'], ['E05.196.566.880'], ['B01.650.940.800.575.912.250.859.797.962']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Twenty-four hour blood pressure and heart rate profiles of diabetic patients with abnormal cardiovascular reflexes. | Twenty-four hour ambulatory blood pressure and heart rate profiles of 24 patients with diabetes were monitored in order to assess the effect of autonomic neuropathy on 24-h haemodynamic profiles. Eighteen patients had abnormal cardiovascular reflexes. Mean arterial pressure rose at night in six of the patients with aut... | ['Adult', 'Blood Pressure', 'Circadian Rhythm', 'Diabetes Mellitus', 'Diabetic Angiopathies', 'Diabetic Neuropathies', 'Female', 'Heart Rate', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Posture', 'Respiration', 'Valsalva Maneuver'] | 1,830,525 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G07.180.562.190'], ['C18.452.394.750', 'C19.246'], ['C14.907.320', 'C19.246.099.500'], ['C10.668.829.300', 'C19.246.099.937'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The impact of histology on recurrence patterns in esophageal cancer treated with definitive chemoradiotherapy. | BACKGROUND: To assess the impact of histology on recurrence patterns and survival outcomes in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT).METHODS: We analyzed 590 consecutive EC patients who received definitive CRT from 1998 to 2014, including 182 patients (30.8%) with squamous ... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Chemoradiotherapy', 'Cisplatin', 'Esophageal Neoplasms', 'Esophageal Squamous Cell Carcinoma', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Retrospective Studies', 'Salvage Therapy', 'Young Adult'] | 28,687,396 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Geographical distribution of Vip3Aa20 resistance allele frequencies in Spodoptera frugiperda (Lepidoptera: Noctuidae) populations in Brazil. | BACKGROUND: The use of Bt plants has been the main strategy for controlling the fall armyworm Spodoptera frugiperda (J. E. Smith) in Brazil. However, many resistance cases were already registered. The resistance of S. frugiperda to the Vip3Aa20 protein was recently characterized under laboratory conditions but it is st... | ['Animals', 'Bacterial Proteins', 'Brazil', 'Endotoxins', 'Gene Frequency', 'Hemolysin Proteins', 'Insect Proteins', 'Insecticide Resistance', 'Larva', 'Plants, Genetically Modified', 'Spodoptera', 'Zea mays'] | 31,106,516 | [['B01.050'], ['D12.776.097'], ['Z01.107.757.176'], ['D23.946.123.329'], ['G05.330'], ['D12.776.543.695.444'], ['D12.776.093.500'], ['G07.690.773.984.491'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.650.520', 'B05.620.600'], ['B01.050.500.131.617.720.500.500.937.650.700'], ['B01.650.940.800.575.912.250.822.966'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
A test of a mitochondrial gene-based phylogeny of woodpeckers (genus Picoides) using an independent nuclear gene, beta-fibrinogen intron 7. | A conservative estimate of the species tree for the woodpecker genus Picoides based on two mitochondrial protein-coding genes is tested using sequences of an independently evolving nuclear intron, beta-fibrinogen intron 7. The mitochondrial gene-based topology and the intron-based topology are concordant, and a partiti... | ['Animals', 'Birds', 'Cell Nucleus', 'Cytochrome b Group', 'DNA', 'DNA, Mitochondrial', 'Electron Transport Complex IV', 'Fibrinogen', 'Introns', 'Molecular Sequence Data', 'Phylogeny', 'Sequence Analysis, DNA'] | 11,820,845 | [['B01.050'], ['B01.050.150.900.248'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D08.244.187', 'D12.776.422.220.187'], ['D13.444.308'], ['D13.444.308.283.225'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.585.450.250.87... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Teicoplanin vs vancomycin: cost-effectiveness comparisons. | The rising incidence of methicillin-resistant staphylococci and resistant enterococci in recent years has led to increased use of vancomycin as an active combatant in the treatment of gram-positive infections. Teicoplanin is an investigational glycopeptide that shares a similar spectrum of activity with vancomycin and ... | ['Cost-Benefit Analysis', 'Drug Costs', 'Formularies, Hospital as Topic', 'Hospital Bed Capacity, 300 to 499', 'Humans', 'Michigan', 'Staphylococcal Infections', 'Teicoplanin', 'Vancomycin'] | 10,123,835 | [['N03.219.151.125'], ['N03.219.151.400.350', 'N05.300.375.300'], ['L01.178.682.192.836.535.561'], ['N02.278.306.472.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.500', 'Z01.107.567.875.510.500'], ['C01.150.252.410.868'], ['D09.400.420.405.500', 'D12.644.233.352.500'], ['D09.400.420.925'... | ['Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Identification of recurrent and novel mutations in the LDL receptor gene in Spanish patients with familial hypercholesterolemia. Mutations in brief no. 135. Online. | We used the single strand conformation polymorphism (SSCP) method to investigate 13 apparently unrelated Spanish patients with familial hypercholesterolemia (FH) for mutations in the promoter region and the 18 exons and their flanking intron sequences of the low density lipoprotein (LDL) receptor gene. We found 16 aber... | ['DNA Mutational Analysis', 'Frameshift Mutation', 'Humans', 'Hyperlipoproteinemia Type II', 'Mutation, Missense', 'Polymorphism, Single-Stranded Conformational', 'Receptors, LDL', 'Spain'] | 10,206,683 | [['E05.393.760.700.300'], ['G05.365.590.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.320.565.398.481', 'C18.452.584.500.500.644.475', 'C18.452.648.398.481'], ['G05.365.590.650'], ['G05.365.795.600'], ['D12.776.543.750.710.450'], ['Z01.542.846']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Peters' anomaly and combination with other malformations (series of 16 patients). | A series of 15 patients with Peters' anomaly observed from 1987-1991 and a patient showing Wolf-Hirschhorn syndrome were studied retrospectively. Combined ocular anomalies were: microphthalmos (9x), myopia (4x), aniridia (2x), cataract (2x). Five of the patients had combined general anomalies: mental retardation, deafn... | ['Abnormalities, Multiple', 'Adult', 'Anterior Eye Segment', 'Child', 'Child, Preschool', 'Corneal Opacity', 'Eye Abnormalities', 'Humans', 'Infant', 'Retrospective Studies'] | 1,495,763 | [['C16.131.077'], ['M01.060.116'], ['A09.371.060'], ['M01.060.406'], ['M01.060.406.448'], ['C11.204.299'], ['C11.250', 'C16.131.384'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of betaine aldehyde dehydrogenase (BetB) as an essential virulence factor of Brucella abortus. | The pathogenic mechanisms of Brucellosis used to adapt to the harsh intracellular environment of the host cell are not fully understood. The present study investigated the in vitro and in vivo characteristics of B. abortus betaine aldehyde dehydrogenase (BetB) (Gene Bank ID: 006932) using a betB deletion mutant constru... | ['Animals', 'Bacterial Adhesion', 'Bacterial Vaccines', 'Betaine-Aldehyde Dehydrogenase', 'Brucella abortus', 'Brucellosis', 'HeLa Cells', 'Humans', 'Macrophages', 'Mice', 'Mice, Inbred BALB C', 'Osmotic Pressure', 'Phagocytes', 'Sequence Deletion', 'Spleen', 'Virulence Factors'] | 24,210,811 | [['B01.050'], ['G06.099.050'], ['D20.215.894.135'], ['D08.811.682.657.163.515'], ['B03.440.400.425.215.500.100', 'B03.660.050.070.100.100'], ['C01.150.252.400.167'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372', 'A11.627.482', 'A11.733.39... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Wounding-Induced Stomatal Closure Requires Jasmonate-Mediated Activation of GORK K+ | Guard cells integrate various hormone signals and environmental cues to balance plant gas exchange and transpiration. The wounding-associated hormone jasmonic acid (JA) and the drought hormone abscisic acid (ABA) both trigger stomatal closure. In contrast to ABA however, the molecular mechanisms of JA-induced stomatal ... | ['Abscisic Acid', 'Arabidopsis', 'Arabidopsis Proteins', 'Phosphorylation', 'Plant Stomata', 'Potassium Channels', 'Signal Transduction'] | 30,528,785 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['A18.024.750.650', 'A18.024.812.650'], ['D12.776.157.530.400.600', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. | Atm, p53, and Gadd45a form part of a DNA-damage cellular response pathway; the absence of any one of these components results in increased genomic instability. We conducted an in vivo examination of the frequency of spontaneous homologous recombination in Atm-, p53-, or Gadd45a-deficient mice. In the absence of p53, we... | ['Animals', 'Ataxia Telangiectasia Mutated Proteins', 'Cell Cycle Proteins', 'DNA-Binding Proteins', 'Eye Color', 'Female', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mutation', 'Nuclear Proteins', 'Protein-Serine-Threonine Kinases', 'Recombination, Genetic', 'Tumor Suppressor Protein p53', 'Tumor Suppressor Proteins'] | 14,500,365 | [['B01.050'], ['D08.811.913.696.620.682.700.097', 'D12.776.157.687.125', 'D12.776.660.720.125'], ['D12.776.167'], ['D12.776.260'], ['G14.340', 'G16.690.360'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['G05.365.590'], ['D12.776.660']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Highly multiplexed antibody suspension bead arrays for plasma protein profiling. | Alongside the increasing availability of affinity reagents, antibody microarrays have become a powerful tool to screen for target proteins in complex samples. Applying directly labeled samples onto arrays instead of using sandwich assays offers an approach to facilitate a systematic, high-throughput, and flexible explo... | ['Antibodies, Immobilized', 'Biotinylation', 'Blood Proteins', 'Humans', 'Protein Array Analysis'] | 23,765,623 | [['D12.776.124.486.485.114.207', 'D12.776.124.790.651.114.207', 'D12.776.377.715.548.114.207', 'D12.776.463.250'], ['E05.601.085', 'G02.111.109', 'G03.162'], ['D12.776.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.588.570.700', 'E05.601.680']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oral health status of vulnerable groups in a village of the Central Highlands, southern Vietnam. | OBJECTIVES: Oral health status of vulnerable people in developing countries tends to be given lower priority than other health issues. Consequently, few studies have examined the oral health status of the poor and minorities in developing countries. We aim to examine the dental caries and periodontal status, and explor... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'DMF Index', 'Dental Caries', 'Developing Countries', 'Dietary Sucrose', 'Ethnic Groups', 'Feeding Behavior', 'Female', 'Humans', 'Male', 'Middle Aged', 'Oral Health', 'Periodontal Diseases', 'Periodontal Index', 'Prevalence', 'Risk Factors', 'Rural Health', 'Surveys... | 16,637,908 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.308.980.438.300.350', 'E06.208.266', 'N05.715.360.300.800.438.300.340', 'N06.850.520.308.980.438.300.350', 'N06.890.160.100'], ['C07.793.720.210'], ['I01.615.500.300'], ['D09.301.831.250', 'D09.698.629.305.770.200', 'D09.947.500.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psycholog... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Mangiferin Mitigates Gastric Ulcer in Ischemia/ Reperfused Rats: Involvement of PPAR-ã, NF-êB and Nrf2/HO-1 Signaling Pathways. | Mangiferin (MF), a xanthonoid from Mangifera indica, has been proved to have antisecretory and antioxidant gastroprotective effects against different gastric ulcer models; however, its molecular mechanism has not been previously elucidated. Therefore, the aim of this study was to test its modulatory effect on several s... | ['Animals', 'Anti-Inflammatory Agents', 'Anti-Ulcer Agents', 'Antioxidants', 'Gene Expression Regulation', 'Heme Oxygenase-1', 'Male', 'Mangifera', 'NF-E2-Related Factor 2', 'NF-kappa B', 'Omeprazole', 'PPAR gamma', 'Rats', 'Rats, Wistar', 'Reperfusion Injury', 'Signal Transduction', 'Stomach Ulcer', 'Xanthones'] | 26,196,679 | [['B01.050'], ['D27.505.954.158'], ['D27.505.954.483.203'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G05.308'], ['D08.811.682.690.708.410.500'], ['B01.650.940.800.575.912.250.044.416'], ['D12.776.260.108.737', 'D12.776.930.127.737'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600', 'D12.776... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stereodynamics of tetramezine. | The antidepressant drug tetramezine [1,2-bis-(3,3-dimethyldiaziridin-1-yl)ethane] consists of two bridged diaziridine moieties with four stereogenic nitrogen centers, which are stereolabile and, therefore, are prone to interconversion. The adjacent substituents at the nitrogen atoms of the diaziridines moieties exist o... | ['Algorithms', 'Antidepressive Agents', 'Aziridines', 'Chromatography, Gas', 'Molecular Conformation', 'Stereoisomerism', 'Thermodynamics'] | 20,845,424 | [['G17.035', 'L01.224.050'], ['D27.505.954.427.700.122'], ['D03.383.097.217'], ['E05.196.181.349'], ['G02.111.570.820'], ['G02.607.445.682'], ['G01.906']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Physical activity and ischaemic heart disease in middle-aged British men. | OBJECTIVE: To assess the relation between reported physical activity and the risk of heart attacks in middle aged British men.DESIGN: Prospective study of middle-aged men followed for a period of eight years (The British Regional Heart Study).SETTING: One general practice in each of 24 British towns.PARTICIPANTS: 7735 ... | ['Adult', 'Age Factors', 'Coronary Disease', 'Follow-Up Studies', 'Forced Expiratory Volume', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Physical Exertion', 'Prospective Studies', 'Risk Factors', 'Sports', 'United Kingdom'] | 1,747,302 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C14.280.647.250', 'C14.907.585.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Allopurinol Administration for the Prevention of Contrast-Induced Nephropathy: A Network Meta-analysis With Trial Sequential Analysis. | Contrast-induced nephropathy represents a major source of morbidity in patients undergoing coronary angiography. Various preventive measures have been proposed, although the optimal one remains still unknown. The aim of the present meta-analysis is to accumulate current literature knowledge and evaluate the renoprotect... | ['Acute Kidney Injury', 'Allopurinol', 'Contrast Media', 'Cytoprotection', 'Fluid Therapy', 'Gout Suppressants', 'Humans', 'Incidence', 'Kidney', 'Network Meta-Analysis', 'Randomized Controlled Trials as Topic', 'Risk Factors', 'Treatment Outcome'] | 30,829,731 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['D03.633.100.759.160'], ['D27.505.259.500', 'D27.720.259'], ['G07.690.773.500'], ['E02.319.360'], ['D27.505.954.329.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis. | This is the first completed prospective randomized clinical efficacy trial of antifungals in the treatment of invasive aspergillosis (IA) and the first to compare the clinical efficacy of two dosages of liposomal amphotericin B (L-AmB) for IA in neutropenic patients with cancer or those undergoing bone marrow transplan... | ['Adult', 'Aged', 'Amphotericin B', 'Antifungal Agents', 'Aspergillosis', 'Drug Carriers', 'Female', 'Humans', 'Liposomes', 'Male', 'Middle Aged', 'Prospective Studies', 'Survival Analysis', 'Treatment Outcome'] | 9,868,651 | [['M01.060.116'], ['M01.060.116.100'], ['D02.540.576.500.500'], ['D27.505.954.122.136'], ['C01.150.703.080'], ['D26.255.260', 'E02.319.300.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['M01.060.116.630'], ['E05.318.372.500.750.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Business oriented EU human cell and tissue product legislation will adversely impact Member States' health care systems. | The transplantation of conventional human cell and tissue grafts, such as heart valve replacements and skin for severely burnt patients, has saved many lives over the last decades. The late eighties saw the emergence of tissue engineering with the focus on the development of biological substitutes that restore or impro... | ['Cell Transplantation', 'Commerce', 'Delivery of Health Care', 'Drug Industry', 'European Union', 'Humans', 'Legislation as Topic', 'Policy', 'Transplants'] | 24,052,113 | [['E02.095.147.500', 'E04.936.225'], ['J01.219'], ['N04.590.374', 'N05.300'], ['J01.576.655.750'], ['I01.615.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.615'], ['I01.655', 'N03.623'], ['A01.941']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Interactions between rat prolactin gene promoter and enhancer regions in mammosomatotrope and lactotrope cell lines. | Although both promoter and enhancer sequences of the PRL gene 5'-flanking DNA are required for cell-specific, high level expression in transgenic animals, reports of the relative contributions of these elements determined in transient transfection experiments have varied. In this study we examined the transcriptional a... | ['Animals', 'DNA, Neoplasm', 'Enhancer Elements, Genetic', 'Gene Expression Regulation, Neoplastic', 'Growth Hormone', 'Pituitary Neoplasms', 'Prolactin', 'Promoter Regions, Genetic', 'Rats', 'Transfection', 'Tumor Cells, Cultured'] | 1,791,833 | [['B01.050'], ['D13.444.308.425'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['G05.308.370'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.140.211.885.500.600', 'C10.228.140.617.477.600', 'C10.228.140... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sexual Scripts and Criminal Statutes: Gender Restrictions, Spousal Allowances, and Victim Accountability After Rape Law Reform. | The author provides a mixed-methods assessment of U.S. rape statutes to assess progress in reform. Contemporary statutes offer restrictive frameworks for distinguishing criminal from noncriminal sexual violence, many of which are grounded in gendered and heterosexist assumptions. Fourteen states retain gender restricti... | ['Crime', 'Crime Victims', 'Criminal Law', 'History, 20th Century', 'History, 21st Century', 'Humans', 'Rape', 'Sexual Behavior', 'Social Perception', 'Social Responsibility', 'United States'] | 29,332,509 | [['I01.198.240', 'I01.880.735.191'], ['M01.135'], ['I01.198.290', 'I01.880.604.583.100'], ['K01.400.504.968'], ['K01.400.504.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.198.240.748.640', 'I01.198.240.856.744', 'I01.880.735.900.772'], ['F01.145.802'], ['F02.463.593.752'], ['F01.829.500.760', 'K01.752.5... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Humanities [K]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Diagnostic value of symptom screening for pulmonary tuberculosis in China. | OBJECTIVE: To evaluate the diagnostic value of symptom screening for tuberculosis (TB) case finding defined in National Tuberculosis Control Program in China (China NTP) among elderly people(?65 years) and younger people(<65 years).METHODS: We made a secondary analysis in a population-based TB prevalence survey in Chin... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Predictive Value of Tests', 'Prevalence', 'Radiography, Thoracic', 'Sensitivity and Specificity', 'Sputum', 'Tuberculosis, Pulmonary'] | 26,001,190 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['M01.060.116.630'], ['E05.318.370.800.650... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genetic diversities of cytochrome B in Xinjiang Uyghur unveiled its origin and migration history. | BACKGROUND: Uyghurs are one of the many populations of Central Eurasia that is considered to be genetically related to Eastern and Western Eurasian populations. However, there are some different opinions on the relative importance of the degree of Eastern and Western Eurasian genetic influence. In addition, the genetic... | ['Asian Continental Ancestry Group', 'China', 'Cytochromes b', 'Genetic Variation', 'Genotype', 'Haplotypes', 'History, Ancient', 'Human Migration', 'Humans', 'Polymorphism, Genetic', 'Sequence Analysis, DNA'] | 24,103,151 | [['M01.686.508.200'], ['Z01.252.474.164'], ['D08.244.187.249', 'D12.776.422.220.187.249'], ['G05.365'], ['G05.380'], ['G05.380.360'], ['K01.400.470'], ['I01.240.600.525', 'N01.224.625.525', 'N06.850.505.400.700.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795'], ['E05.393.760.700']] | ['Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Prevalence of iron deficiency anemia in a group of pre-school and school children, living in conditions of poverty]. | Iron deficiency is common during the first years of life. Yet, there is a paucity of data on scholar children. Our main objective was to estimate the prevalence of ferropenic anemia in children 3 to 12 years of age living under conditions of poverty. A total of 323 children were included, 171 attended to a day care ins... | ['Anemia, Iron-Deficiency', 'Argentina', 'Child', 'Child Day Care Centers', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Poverty', 'Prevalence'] | 15,637,823 | [['C15.378.071.196.300', 'C18.452.565.100'], ['Z01.107.757.077'], ['M01.060.406'], ['J03.160', 'N02.421.143.098'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.... | ['Diseases [C]', 'Geographicals [Z]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Is an antiemetic prophylactic treatment needed for patients submitted to consecutive days of 5-fluorouracil? An observational study. | AIMS AND BACKGROUND: The necessity of an antiemetic prophylaxis in patients treated with chemotherapy of low emetogenic potential, such as 5-fluorouracil +/- folinic acid fractionated over several consecutive days, is controversial. The aim of the study was to evaluate the therapeutic behavior of oncologists on this is... | ['Aged', 'Antiemetics', 'Antimetabolites, Antineoplastic', 'Antineoplastic Combined Chemotherapy Protocols', 'Drug Administration Schedule', 'Drug Prescriptions', 'Female', 'Fluorouracil', 'Humans', 'Incidence', 'Italy', 'Leucovorin', 'Male', 'Medical Oncology', 'Middle Aged', 'Outcome and Process Assessment, Health Ca... | 11,989,589 | [['M01.060.116.100'], ['D27.505.696.663.050.030', 'D27.505.954.427.095', 'D27.505.954.483.200'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.319.283'], ['E02.319.307', 'N02.421.668.778.500'], ['D03.383.742.698.875.404'], ['B01.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides. | There is a pressing need for the development of novel adjuvants for human use. The minimal bioactive structure of bacterial peptidoglycan (PGN), muramyldipeptide (MDP), and its derivative murabutide (MB) have long been known for their adjuvant activities. For this reason, a series of novel desmuramyldipeptides have bee... | ['Acetylmuramyl-Alanyl-Isoglutamine', 'Cytokines', 'Dipeptides', 'Dose-Response Relationship, Drug', 'Drug Design', 'HEK293 Cells', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Immunologic Factors', 'Leukocytes, Mononuclear', 'Nod2 Signaling Adaptor Protein', 'Time Factors'] | 22,716,113 | [['D09.067.550.050', 'D09.811.522.050', 'D12.644.233.050'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.644.456.345'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Carotid artery stenting in the first 100 consecutive patients: results and follow up. | BACKGROUND: Carotid artery stenting is now used as an alternative to surgical endarterectomy. The availability of cerebral protection systems has expanded the area of application of this procedure.OBJECTIVE: To assess the feasibility, safety, and immediate and late clinical outcome in patients undergoing percutaneous c... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carotid Stenosis', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Ischemic Attack, Transient', 'Male', 'Middle Aged', 'Recurrence', 'Stents'] | 12,231,597 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.15... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pyriform sinus malformations: a cadaveric representation. | BACKGROUND/PURPOSE: The most important aspects in management of pyriform sinus malformations are awareness of the diagnosis, familiarity with the clinical manifestations, and complete surgical excision of the entire tract. Pyriform sinus anomalies are the least common branchial apparatus malformations and present anato... | ['Abscess', 'Adolescent', 'Airway Obstruction', 'Branchial Region', 'Bronchial Neoplasms', 'Cadaver', 'Child', 'Female', 'Humans', 'Hypopharynx', 'Infant, Newborn', 'Larynx', 'Male', 'Models, Anatomic', 'Pharyngeal Neoplasms', 'Retropharyngeal Abscess', 'Thyroiditis, Suppurative'] | 11,877,683 | [['C01.830.025', 'C23.550.470.756.100'], ['M01.060.057'], ['C08.618.846.185'], ['A16.142'], ['C04.588.894.797.520.109', 'C08.127.265', 'C08.785.520.100'], ['C23.550.260.224'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.623.490', 'A14.724.490'], ['M01.060.703.520'], ['A04.329'], ['J01.897.28... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Precipitation, stabilization and molecular modeling of ZnS nanoparticles in the presence of cetyltrimethylammonium bromide. | ZnS nanoparticles were precipitated in aqueous dispersions of cationic surfactant cetyltrimethylammonium bromide (CTAB). The sphere radii of ZnS nanoparticles calculated by using band-gap energies steeply decreased from 4.5 nm to 2.2 nm within CTAB concentrations of 0.4-1.5 mmol L(-1). Above the concentration of 1.5 mm... | ['Cetrimonium', 'Cetrimonium Compounds', 'Chemical Precipitation', 'Light', 'Models, Molecular', 'Nanoparticles', 'Particle Size', 'Scattering, Radiation', 'Spectrophotometry, Ultraviolet', 'Surface Properties', 'Surface-Active Agents', 'Zinc Sulfate'] | 22,520,213 | [['D02.092.877.883.111.500', 'D02.675.276.190.500'], ['D02.092.877.883.111', 'D02.675.276.190'], ['E05.196.150', 'G02.159'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.595'], ['J01.637.512.600'], ['G02.712'], ['E05.196.822', 'G01.867'], ['E05.196.712.726.802', 'E05.196.867.8... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Survival and neurodevelopmental outcomes of preterm infants. | Survival of preterm infants, which increased dramatically during the years after the introduction of neonatal intensive care, reached a plateau in the mid- to late 1990s. Neonatal morbidity, which increased initially, has decreased since 2000 and resulted in a decrease in the rates of cerebral palsy. Follow-up of prete... | ['Cerebral Palsy', 'Child', 'Child Development', 'Child, Preschool', 'Developmental Disabilities', 'Humans', 'Infant', 'Infant Mortality', 'Infant, Newborn', 'Infant, Premature', 'Prognosis', 'Survival Analysis'] | 18,185,079 | [['C10.228.140.140.254'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['F03.625.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N06.850.505.400.975.550.475', 'N06.850.520.308.985.550.475'], ['M01.060.703.520'], ['... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Choledochotomy and primary repair of extrahepatic biliary duct rupture in seven dogs and two cats. | OBJECTIVE: To report clinical findings and outcome in dogs and cats undergoing choledochotomy or primary repair of extrahepatic biliary duct rupture.METHODS: Retrospective study of dogs (n=7) and cats (n=2) that had choledochotomy or primary bile duct repair.RESULTS: Extrahepatic biliary obstruction was confirmed at su... | ['Animals', 'Bile Duct Diseases', 'Bile Ducts, Extrahepatic', 'Biliary Tract Surgical Procedures', 'Cat Diseases', 'Cats', 'Choledocholithiasis', 'Cholestasis, Extrahepatic', 'Dog Diseases', 'Dogs', 'Female', 'Gallbladder', 'Gallbladder Diseases', 'Male', 'Retrospective Studies', 'Rupture, Spontaneous', 'Treatment Outc... | 21,143,234 | [['B01.050'], ['C06.130.120'], ['A03.159.183.079'], ['E04.210.120'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C06.130.120.250.174', 'C06.130.409.267'], ['C06.130.120.135.150'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A03.159.439'], ['C06.130.564'], ['E05.318.372.500.500.500', ... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Repeated whole cigarette smoke exposure alters cell differentiation and augments secretion of inflammatory mediators in air-liquid interface three-dimensional co-culture model of human bronchial tissue. | In vitro models of human bronchial epithelium are useful for toxicological testing because of their resemblance to in vivo tissue. We constructed a model of human bronchial tissue which has a fibroblast layer embedded in a collagen matrix directly below a fully-differentiated epithelial cell layer. The model was applie... | ['Bronchi', 'Cell Differentiation', 'Coculture Techniques', 'Cytochrome P-450 CYP1A1', 'Cytokines', 'Epithelial Cells', 'Fibroblasts', 'Gene Expression', 'Humans', 'NF-kappa B', 'Smoke', 'Tissue Culture Techniques', 'Tobacco'] | 27,596,523 | [['A04.411.125'], ['G04.152'], ['E05.481.500.374'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332', 'D12.776.422.220.453.100.500'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.436'], ['A11.329.228'], ['G... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell transformation by v-Jun deactivates ERK MAP kinase signalling. | Previous studies have shown that v-Jun accelerates G1 progression and enables cells to sustain S phase entry in the absence of serum growth factors. Since growth factor-dependent ERK MAP kinase signalling plays an important role in regulating the G1/S transition, we investigated whether aberrant ERK regulation might co... | ['Animals', 'Blotting, Western', 'Cell Division', 'Cell Transformation, Neoplastic', 'Chick Embryo', 'Down-Regulation', 'Fibroblasts', 'Humans', 'Immunoenzyme Techniques', 'MAP Kinase Kinase Kinase 1', 'Mitogen-Activated Protein Kinases', 'Oncogene Protein p65(gag-jun)', 'Phosphorylation', 'Protein-Serine-Threonine Kin... | 12,226,757 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A13.350.150', 'A16.331.200'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Altered metabolic incorporation of fucose and leucine into PNS myelin of 25-week-old diabetic (C57BL/Ks [db/db]) mice: effects of untreated diabetes on nerve metabolism. | Sciatic nerves of 25-week-old genetically diabetic (C57BL/Ks [db/db]) mice and their litter-mate controls were removed, and their metabolic incorporation of [3H]fucose and [14C]leucine into myelin was studied in vitro. Untreated diabetic animals showed significant increases (p less than 0.05) in the fucose/leucine inco... | ['Animals', 'Carbon Radioisotopes', 'Diabetes Mellitus, Experimental', 'Diabetic Neuropathies', 'Fucose', 'Leucine', 'Male', 'Mice', 'Mice, Mutant Strains', 'Myelin Proteins', 'Myelin Sheath', 'Sciatic Nerve', 'Tritium'] | 6,888,648 | [['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C10.668.829.300', 'C19.246.099.937'], ['D09.254.488'], ['D12.125.070.637', 'D12.125.142.441'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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