Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Human kidney anion exchanger 1 interacts with kinesin family member 3B (KIF3B). | Impaired trafficking of human kidney anion exchanger 1 (kAE1) to the basolateral membrane of á-intercalated cells of the kidney collecting duct leads to the defect of the Cl(-)/HCO(3)(-) exchange and the failure of proton (H(+)) secretion at the apical membrane of these cells, causing distal renal tubular acidosis (dRT... | ['Amino Acid Motifs', 'Anion Exchange Protein 1, Erythrocyte', 'Gene Knockdown Techniques', 'HEK293 Cells', 'Humans', 'Immunoprecipitation', 'Kidney', 'Kinesin'] | 21,871,436 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D12.776.157.530.450.162.193.500', 'D12.776.157.530.450.437.249.500', 'D12.776.157.530.937.656.249.500', 'D12.776.543.550.190.276.500', 'D12.776.543.550.779.249.500', 'D12.776.543.585.450.162.193.500', 'D12.776.543.585.450.437.249.500', 'D12.776.543.585.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Application of growth-related sublethal endpoints in ecotoxicological assessments using a harpacticoid copepod. | In ecotoxicology, there is an increasing demand for sensitive sublethal endpoints. The primary aim of the present study was therefore to evaluate the relative sensitivity and usefulness of four sublethal endpoints - development time, body length, RNA content and growth rate - in the harpacticoid copepod Nitocra spinipe... | ['Animals', 'Body Size', 'Copepoda', 'Dose-Response Relationship, Drug', 'Environmental Monitoring', 'Growth and Development', 'Mortality', 'RNA', 'Simvastatin', 'Time Factors', 'Toxicity Tests', 'Water Pollutants, Chemical'] | 16,504,314 | [['B01.050'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['B01.050.500.131.365.160'], ['G07.690.773.875', 'G07.690.936.500'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G07.345'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains. | Pseudomonas aeruginosa PAO1 is the most commonly used strain for research on this ubiquitous and metabolically versatile opportunistic pathogen. Strain PAO1, a derivative of the original Australian PAO isolate, has been distributed worldwide to laboratories and strain collections. Over decades discordant phenotypes of ... | ['Amino Acid Substitution', 'Animals', 'Chromosome Inversion', 'Chromosomes, Bacterial', 'DNA, Bacterial', 'Female', 'Gene Duplication', 'Genetic Variation', 'Laboratories', 'Mice', 'Mice, Inbred C3H', 'Molecular Sequence Data', 'Physical Chromosome Mapping', 'Point Mutation', 'Pseudomonas Infections', 'Pseudomonas aer... | 20,023,018 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['C23.550.210.190', 'G05.365.590.175.190', 'G05.365.590.770.500', 'G05.558.805.500'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['D13.444.308.212'], ['G05.365.590.320', 'G05.558.320'], ['G05.365'], ['J03.520', 'N02.278.487'], ['B01.050.150.900.649.313.992.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis. | OBJECTIVES: Listeria monocytogenes is a food-borne pathogen that can cause meningitis. The listerial genotype ST6 has been linked to increasing rates of unfavourable outcome over time. We investigated listerial genetic variation and the relation with clinical outcome in meningitis.METHODS: We sequenced 96 isolates from... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Anti-Infective Agents, Local', 'Benzalkonium Compounds', 'Cohort Studies', 'Drug Resistance, Bacterial', 'Female', 'Genetic Variation', 'Genome, Bacterial', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Listeria monocytogenes', 'Male', 'Meningitis, ... | 27,998,823 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['D27.505.954.122.187'], ['D02.092.877.096.040', 'D02.675.276.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['G05.365'], ['G05.360.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Leadership, organizational stress, and emotional exhaustion among hospital nursing staff. | UNLABELLED: STUDY'S RATIONALE AND OBJECTIVES: We examined the effect of work stressors and head nurses' transactional and transformational leadership on the levels of emotional exhaustion experienced among their staff.METHODOLOGICAL DESIGN AND RESEARCH METHODS: A questionnaire was sent to all nurses of a university hos... | ['Adult', 'Belgium', 'Burnout, Professional', 'Female', 'Humans', 'Interprofessional Relations', 'Leadership', 'Male', 'Multivariate Analysis', 'Nursing Staff, Hospital', 'Regression Analysis', 'Role', 'Social Support', 'Task Performance and Analysis', 'Workload'] | 11,529,953 | [['M01.060.116'], ['Z01.542.115'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['F01.752.609'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Experimental trichinellosis in horses: biological and parasitological evaluation. | Three groups of three horses each were, respectively, infected with 5000, 20,000 and 50,000 larvae of Trichinella spiralis. The strain used was isolated from a human biopsy during horsemeat-related outbreaks of trichinellosis in France. Transient muscular disorders were only observed in two of the horses infected with ... | ['Animals', 'Creatine Kinase', 'Diaphragm', 'Enzyme-Linked Immunosorbent Assay', 'Eosinophils', 'Female', 'Fluorescent Antibody Technique', 'Fructose-Bisphosphate Aldolase', 'Horse Diseases', 'Horses', 'Immunoglobulin G', 'L-Lactate Dehydrogenase', 'Leukocyte Count', 'Male', 'Masseter Muscle', 'Tongue', 'Trichinellosis... | 2,658,299 | [['B01.050'], ['D08.811.913.696.640.150'], ['A02.633.567.900.300'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['E01.370.225.500.607.512.240', 'E01.370.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lack of small intestinal ulcerogenecity of nitric oxide-releasing indomethacin, NCX-530, in rats. | AIM: To evaluate the intestinal ulcerogenic property of nitric oxide-releasing indomethacin (NCX-530) in the rat, in comparison with indomethacin.METHODS: Animals were given indomethacin or NCX-530 subcutaneously and killed 24 h later for macroscopic examination of the small intestine.RESULTS: A single administration o... | ['Acetates', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Bacterial Translocation', 'Indoles', 'Indomethacin', 'Injections, Subcutaneous', 'Intestinal Mucosa', 'Intestine, Small', 'Male', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Peroxidase', 'Rats', 'Rats, Sprague-Dawley'] | 11,148,446 | [['D02.241.081.018', 'D10.251.400.045'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G06.099.114'], ['D03.633.100.473'], ['D03.633.100.473.420'], ['E02.319.267.530.620'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.684'], ['D01.339.387', 'D01.625.550.500',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gorlin-Goltz syndrome. | BACKGROUND: Gorlin-Goltz syndrome is an autosomal dominant inherited disorder characterized by a predisposition to various cancers. Clinicopathological findings of syndrome are very diverse and many symptoms begin to manifest in a certain period of life.CASE: The authors describe a case report of a man who, at the age ... | ['Adult', 'Basal Cell Nevus Syndrome', 'Humans', 'Male', 'Prognosis'] | 30,995,852 | [['M01.060.116'], ['C04.182.089.530.690.150', 'C04.557.470.200.165.150', 'C04.557.470.565.165.150', 'C04.700.175', 'C05.116.099.105', 'C05.500.470.690.150', 'C07.320.450.670.130', 'C16.131.077.130', 'C16.320.700.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
RETRACTED: Effects of ethanol on monosodium urate crystal-induced inflammation. | This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).
This article has been retracted at the request of the Editor-in-Chief.
Image duplication has been observed within Figure 3. The corresponding author has been asked... | ['Animals', 'Cell Line, Tumor', 'Crystallization', 'Ethanol', 'Female', 'Humans', 'Inflammation', 'Inflammation Mediators', 'Leukocytes', 'Mice', 'Mice, Inbred C57BL', 'Monocytes', 'Neutrophils', 'Uric Acid'] | 18,282,764 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.300', 'G02.171'], ['D02.033.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['D23.469'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.9... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Polyviologen as Electron Transport Material in Photosystem I-Based Biophotovoltaic Cells. | The photosynthetic protein complex, photosystem I (PSI), can be photoexcited with a quantum efficiency approaching unity and can be integrated into solar energy conversion devices as the photoactive electrode. The incorporation of PSI into conducting polymer frameworks allows for improved conductivity and orientational... | ['Bioelectric Energy Sources', 'Electrochemistry', 'Electrodes', 'Electrons', 'Oxidation-Reduction', 'Photosystem I Protein Complex', 'Polymers', 'Solar Energy', 'Viologens'] | 30,495,963 | [['E07.305.124.150'], ['H01.181.529.307'], ['E07.305.250'], ['G01.249.335', 'G01.358.500.750'], ['G02.700', 'G03.295.531'], ['D05.500.562.488.500', 'D08.811.600.710.500', 'D12.776.157.530.450.250.875.492', 'D12.776.543.585.450.250.875.492', 'D12.776.543.930.500.500', 'D12.776.765.199.750.750.500'], ['D05.750', 'D25.720... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Yours, mine, and ours: the importance of scientific collaboration in advancing the field of behavior change research. | The Behavior Change Consortium (BCC) has provided a unique opportunity to combine and explore resources, data, processes, and knowledge as a means of strengthening the validity, reliability, and outcomes that compose the field of behavioral science. The workgroups of the BCC were able to transcend disciplinary boundari... | ['Behavior Therapy', 'Behavioral Research', 'Cooperative Behavior', 'Feedback', 'Health Behavior', 'Humans', 'Interdisciplinary Communication', 'Peer Review'] | 15,921,484 | [['F04.754.137'], ['F04.096.144', 'H01.770.644.108'], ['F01.145.813.115'], ['L01.906.394.211'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143.865.500'], ['F01.829.316.549', 'I01.880.604.640', 'N03.706.700']] | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
The pregnancy-induced increase of plasma angiotensin-(1-7) is blunted in gestational diabetes. | BACKGROUND AND OBJECTIVE: It has been shown that the circulating Renin-Angiotensin System (RAS) is activated during normal pregnancy, but little is known about RAS in pregnancies complicated by gestational diabetes (GDM). GDM is considered not merely a temporary condition, but a harbinger of hypertension and type 2 dia... | ['Adult', 'Angiotensin I', 'Angiotensin II', 'Case-Control Studies', 'Diabetes, Gestational', 'Female', 'Gestational Age', 'Humans', 'Peptide Fragments', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Pregnancy Trimester, Third', 'Radioimmunoassay', 'Renin-Angiotensin System'] | 17,291,601 | [['M01.060.116'], ['D06.472.699.094.075', 'D12.644.400.070.075', 'D12.644.456.073.021', 'D12.644.548.058.075', 'D12.776.631.650.070.075', 'D23.469.050.050.025'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['E05.318.372.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of fluconazole on pharmacokinetics of 2',3'-dideoxyinosine in persons seropositive for human immunodeficiency virus. | Fluconazole inhibits cytochrome P-450-mediated enzymatic metabolism of several drugs. Since hepatic metabolism is partially responsible for 2',3'-dideoxyinosine (didanosine or ddI) elimination, fluconazole therapy may lead to increased ddI concentrations in serum and subsequent concentration-dependent adverse effects. ... | ['Adult', 'Didanosine', 'Drug Interactions', 'Female', 'Fluconazole', 'HIV Seropositivity', 'Half-Life', 'Humans', 'Male', 'Middle Aged', 'Radioimmunoassay'] | 7,625,787 | [['M01.060.116'], ['D03.633.100.759.590.616.130', 'D13.570.230.500.090', 'D13.570.583.616.130', 'D13.570.800.573.130'], ['G07.690.773.968'], ['D03.383.129.799.450'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500', 'C01.925.813.400.500', 'C20.673.480.500'], ['G01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Soluble tumour-specific antigen and its relationship to tumour growth. | Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capacit... | ['Animals', 'Antibodies, Neoplasm', 'Antibody Specificity', 'Antigens, Neoplasm', 'BCG Vaccine', 'Epitopes', 'Graft Rejection', 'Immunization', 'Male', 'Methylcholanthrene', 'Neoplasm Transplantation', 'Rats', 'Rats, Inbred Strains', 'Sarcoma, Experimental', 'Transplantation, Homologous'] | 50,290 | [['B01.050'], ['D12.776.124.486.485.114.240', 'D12.776.124.790.651.114.240', 'D12.776.377.715.548.114.240'], ['G12.100'], ['D23.050.285'], ['D20.215.894.135.825.100'], ['D23.050.550'], ['G12.875.545.328'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['D02... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString). | BACKGROUND: Neuroendocrine tumors of the lung (NELC) account for 25% of all lung cancer cases and transcription factors may drive dedifferentiation of these tumors. This study was conducted to identify supportive diagnostic and prognostic biomarkers.MATERIALS & METHODS: A total of 16 TC, 13 AC, 16 large cell neuroendoc... | ['Aged', 'Biomarkers, Tumor', 'Eye Proteins', 'Gene Expression Profiling', 'Homeodomain Proteins', 'Humans', 'Lung Neoplasms', 'Lymphatic Metastasis', 'Middle Aged', 'Neuroendocrine Tumors', 'PAX6 Transcription Factor', 'Paired Box Transcription Factors', 'RNA, Messenger', 'Repressor Proteins', 'SOXC Transcription Fact... | 25,804,118 | [['M01.060.116.100'], ['D23.101.140'], ['D12.776.306'], ['E05.393.332'], ['D12.776.260.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['C04.557.465.625.650', 'C04.557.580.625.650'], ['D12.776... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
NDRG1 deficiency is associated with regional metastasis in oral cancer by inducing epithelial-mesenchymal transition. | Regional metastasis is the single most important prognostic factor in oral squamous cell carcinoma (OSCC). Abnormal expression of N-myc downstream-regulated genes (NDRGs) has been identified to occur in several tumor types and to predict poor prognosis. In OSCC, the clinical significance of deregulated NDRG expression ... | ['Animals', 'Apoptosis', 'Biomarkers, Tumor', 'Carcinoma, Squamous Cell', 'Cell Cycle Proteins', 'Cell Proliferation', 'Epithelial-Mesenchymal Transition', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Mouth N... | 32,112,078 | [['B01.050'], ['G04.146.954.035'], ['D23.101.140'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D12.776.167'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.356.500'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['B01.050.150.900.649.313.992.635.505.500'], ['B... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Blood pressure and lifespan following brief ACE inhibitor treatment in young spontaneously hypertensive rats. | 1. Brief treatment with angiotensin-converting enzyme (ACE) inhibitors in young spontaneously hypertensive rats (SHR) causes a reduction in blood pressure that persists into maturity. The lifetime effects of such treatment have not been studied. 2. Nineteen male SHR were treated with either water (n = 9) or perindopril... | ['Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Blood Pressure', 'Body Weight', 'Indoles', 'Life Expectancy', 'Male', 'Perindopril', 'Rats', 'Rats, Inbred SHR'] | 8,039,264 | [['D27.505.519.389.745.085'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D03.633.100.473'], ['E05.318.308.985.450', 'N01.224.935.464', 'N06.850.505.400.975.450', 'N06.850.520.308.985.450'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Neuropeptide FF receptors 1 and 2 exert an anti-opioid activity in acutely dissociated rat dorsal raphe and periventricular hypothalamic neurones. | We measured the reduction by nociceptin of the [Ca(2+)](i) transient triggered by depolarization in acutely dissociated neurones of the rat dorsal raphe and periventricular hypothalamic nuclei that express NPFF(2) and NPFF(1) receptors, respectively, in the absence and presence of 10 nM of NPA-NPFF or NPVF, two peptide... | ['Animals', 'Humans', 'Neural Inhibition', 'Neurons', 'Opioid Peptides', 'Paraventricular Hypothalamic Nucleus', 'Raphe Nuclei', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Neuropeptide'] | 12,932,818 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.265.755', 'G11.561.616'], ['A08.675', 'A11.671'], ['D12.644.400.575', 'D12.776.631.650.575'], ['A08.186.211.180.497.342.400', 'A08.186.211.200.317.357.342.400'], ['A08.186.211.132.659.413.875.618', 'A08.186.211.132.810.428.600.650.562', 'A08.186.211.1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hybridization of evolutionary algorithms and local search by means of a clustering method. | This paper presents a hybrid evolutionary algorithm (EA) to solve nonlinear-regression problems. Although EAs have proven their ability to explore large search spaces, they are comparatively inefficient in fine tuning the solution. This drawback is usually avoided by means of local optimization algorithms that are appl... | ['Algorithms', 'Artificial Intelligence', 'Biological Evolution', 'Cluster Analysis', 'Information Storage and Retrieval', 'Nonlinear Dynamics', 'Pattern Recognition, Automated', 'Regression Analysis'] | 16,761,808 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['G05.045', 'G16.075'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['L01.313.500.750.280', 'L01.470'], ['E05.599.850', 'H01.548.675'], ['L01.399.750'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Comparison of adaptive neuro-fuzzy inference system (ANFIS) and Gaussian processes for machine learning (GPML) algorithms for the prediction of skin temperature in lower limb prostheses. | Monitoring of the interface temperature at skin level in lower-limb prosthesis is notoriously complicated. This is due to the flexible nature of the interface liners used impeding the required consistent positioning of the temperature sensors during donning and doffing. Predicting the in-socket residual limb temperatur... | ['Amputees', 'Artificial Limbs', 'Fuzzy Logic', 'Lower Extremity', 'Neural Networks, Computer', 'Normal Distribution', 'Skin Temperature'] | 27,452,775 | [['M01.150.100'], ['E07.695.050', 'E07.858.082.050', 'E07.858.442.050'], ['E05.599.250', 'K01.752.448.250', 'L01.224.050.375.250'], ['A01.378.610'], ['G17.485', 'L01.224.050.375.605'], ['E05.318.740.994.500', 'G17.820.500', 'N05.715.360.750.750.565', 'N06.850.520.830.994.500'], ['G07.110.753', 'G13.750.844']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Information Science [L]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Monoclonal antibodies specific for the tau subunit of the DNA polymerase III holoenzyme of Escherichia coli. Use to demonstrate that tau is the product of the dnaZX gene and that both it and gamma, the dnaZ gene product, are integral components of the same enzyme assembly. | We have established two murine hybridoma cell lines that secrete monoclonal antibodies directed against the tau subunit of the DNA polymerase III holoenzyme of Escherichia coli. Both antibodies have been purified and identified to be of the IgG1 class. Competition assays indicate that they bind to two distinct portions... | ['Antibodies, Bacterial', 'Antibodies, Monoclonal', 'Bacterial Proteins', 'DNA Polymerase III', 'DNA-Directed DNA Polymerase', 'Escherichia coli', 'Genes', 'Genes, Bacterial', 'Multienzyme Complexes'] | 3,040,763 | [['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.097'], ['D08.811.913.696.445.308.300.235'], ['D08.811.913.696.445.308.300'], ['B03.440.450.425.325.300', 'B03.660.250.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predominantly night-time feeding and maternal glycaemic levels during pregnancy. | Little is known about the influence of meal timing and energy consumption patterns throughout the day on glucose regulation during pregnancy. We examined the association of maternal feeding patterns with glycaemic levels among lean and overweight pregnant women. In a prospective cohort study in Singapore, maternal 24-h... | ['Adiposity', 'Adolescent', 'Adult', 'Blood Glucose', 'Body Mass Index', 'Diabetes, Gestational', 'Energy Intake', 'Feeding Behavior', 'Female', 'Humans', 'Linear Models', 'Overweight', 'Postprandial Period', 'Pregnancy', 'Prospective Studies', 'Reference Values', 'Young Adult'] | 26,949,026 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.057'], ['M01.060.116'], ['D09.947.875.359.448.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C13.703.170', 'C18.452.394.750.448', 'C19.246.200'], ['G07.203... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Generalized SMASH imaging. | A generalized parallel imaging method has been developed that uses coil profiles to generate missing k-space lines. The proposed method is an extension of SMASH, which uses linear combinations of coil sensitivity profiles to synthesize spatial harmonics. In the generalized SMASH approach described here, coil sensitivit... | ['Fourier Analysis', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Phantoms, Imaging'] | 11,754,455 | [['E05.377', 'G17.226', 'L01.224.800.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['E07.671']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Characterization of an equine mannose-binding lectin and its roles in disease. | The mannose-binding lectin (MBL), a pattern recognition serum protein, participates in the innate immune system of mammals as an opsonin. In humans, MBL plays a key role in first-line host defense against infection during the lag period prior to the development of a specific immune response. MBL also activates compleme... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Female', 'Horse Diseases', 'Horses', 'Mannose-Binding Lectins', 'Mannose-Binding Protein-Associated Serine Proteases', 'Molecular Sequence Data', 'Phylogeny', 'Sequence Alignment'] | 16,574,074 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['D12.776.503.311'], ['D08.811.277.656.300.760.501', 'D08.811.277.656.959.350.501', 'D12.776.124.486.274.045.387.875'], ['L01.453.245.667'], ['G05.69... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Life after funding: a strategy for survival of a program to prevent substance abuse. | Problems associated with the use of alcohol and other drugs are among the most serious public health threats found on college and university campuses in the United States. The United States Department of Education's Fund for the Improvement of Postsecondary Education program has supported a nationwide effort among coll... | ['Alcoholism', 'California', 'Cost Control', 'Fund Raising', 'Humans', 'Organizations, Nonprofit', 'Student Health Services', 'Substance-Related Disorders', 'United States'] | 8,908,882 | [['C25.775.100.250', 'F03.900.100.350'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['N03.219.151.160'], ['N03.219.463.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.540.630'], ['N02.421.897'], ['C25.775', 'F03.900'], ['Z01.107.567.875']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Antagonism of morphine analgesia by prolyl-leucyl-glycinamide (MIF-1) in humans. | Prolyl-leucyl-glycinamide (MIF-1) has been observed to inhibit the analgesic effect of morphine in a series of animal studies. In the present study, the naloxone-like properties of MIF-1 were assessed in human subjects. Eight men received a capsule containing 60 mg of MIF-1 or placebo followed one hour later by a 10 mg... | ['Adult', 'Cold Temperature', 'Double-Blind Method', 'Humans', 'MSH Release-Inhibiting Hormone', 'Male', 'Morphine', 'Pain', 'Time Factors'] | 6,151,672 | [['M01.060.116'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.327.700.500', 'D... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chloroquine-Primaquine versus Chloroquine Alone to Treat Vivax Malaria in Afghanistan: An Open Randomized Superiority Trial. | Afghanistan's national guidelines recommend primaquine (PQ) for radical treatment of Plasmodium vivax malaria, but this is rarely implemented because of concerns over potential hemolysis in patients who have G6PD deficiency. Between August 2009 and February 2014, we conducted an open-label, randomized controlled trial ... | ['Adolescent', 'Adult', 'Afghanistan', 'Aged', 'Aged, 80 and over', 'Antimalarials', 'Child', 'Child, Preschool', 'Chloroquine', 'Drug Therapy, Combination', 'Female', 'Follow-Up Studies', 'Genotyping Techniques', 'Glucosephosphate Dehydrogenase Deficiency', 'Humans', 'Malaria, Vivax', 'Male', 'Middle Aged', 'Plasmodiu... | 29,141,719 | [['M01.060.057'], ['M01.060.116'], ['Z01.252.245.500.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.250.100.085'], ['M01.060.406'], ['M01.060.406.448'], ['D03.633.100.810.050.180'], ['E02.319.310'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.... | ['Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A newly discovered tRNA(1Asp) gene (aspV) of Escherichia coli K12. | We report a new tRNA(1Asp) gene near the dnaQ gene, which is located at 5 min on the Escherichia coli linkage map. We named it aspV. The sequence corresponding to the mature tRNA is identical with that of the two previously identified tRNA(1Asp) genes (aspT and aspU), but there is no homology in the sequences of their ... | ['Base Sequence', 'Escherichia coli', 'Genes', 'Genes, Bacterial', 'Genetic Linkage', 'RNA, Transfer, Amino Acyl'] | 3,295,485 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.348'], ['D12.125.780', 'D13.444.735.757.715']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ultrasonographic ovarian dynamic, plasma progesterone, and non-esterified fatty acids in lame postpartum dairy cows. | The objective of this study was to compare ovulation rate, number of large ovarian follicles, and concentrations of plasma progesterone (P4) and non-esterified fatty acids (NEFA) between lame (n = 10) and non-lame (n = 10) lactating Holstein cows. The study was conducted in an organic dairy farm, and cows were evaluate... | ['Animals', 'Cattle', 'Cattle Diseases', 'Fatty Acids, Nonesterified', 'Female', 'Lameness, Animal', 'Ovarian Follicle', 'Ovulation', 'Progesterone', 'Ultrasonography'] | 29,486,532 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['D10.251.310'], ['C22.510'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['G08.686.784.690'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['E01.370.350.850']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unveiling patterns of salary inequity: suggested measurement strategy for health care organizations. | This paper focuses on how potential race related salary inequity and racial discrimination patterns can be measured in health care organizations. Incorporating ethical principals to the measurement strategy helps conceptualize potential patterns of salary inequity. Convergent validity assessment through triangulation m... | ['Female', 'Health Facilities', 'Humans', 'Male', 'Minority Groups', 'Prejudice', 'Salaries and Fringe Benefits', 'Truth Disclosure', 'United States'] | 16,803,747 | [['N02.278'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.853.300'], ['F01.145.813.550', 'F01.829.595'], ['N01.824.417.700', 'N04.452.677.800'], ['F01.829.401.046.800', 'I01.880.604.583.080.134.800'], ['Z01.107.567.875']] | ['Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Time course of the distribution of morphine in brain regions and spinal cord after intravenous injection to spontaneously hypertensive and normotensive Wistar-Kyoto rats. | Previous studies from this laboratory have demonstrated that the analgesic and hyperthermic effects of morphine were found to be greater in spontaneously hypertensive (SHR) rats than in normotensive Wistar-Kyoto (WKY) rats. The enhanced response to morphine could not be explained on the basis of any of the pharmacokine... | ['Analgesia', 'Animals', 'Blood Pressure', 'Body Temperature', 'Brain', 'Injections, Intravenous', 'Male', 'Morphine', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY', 'Species Specificity', 'Spinal Cord', 'Tissue Distribution'] | 1,602,368 | [['E03.091'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.571'], ['B01.050.150.900.649.313.992.635.505.700'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Archenteron cells are responsible for the increase in ribosomal RNA synthesis in sea urchin gastrulae. | Paracentrotus lividus embryos were continuously labeled with P32 from hatching blastula to pluteus. The archenteron cells were then separated from the rest of the embryo and the radioactivity accumulated into the ribosomal RNA of the two cell groups measured. The results clearly indicate that the bulk of ribosomal RNA ... | ['Animals', 'Blastocyst', 'Ectoderm', 'Embryo, Nonmammalian', 'Gastrula', 'RNA, Ribosomal', 'Sea Urchins'] | 509,544 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preoperative assessment of the infant, child, and adolescent. | The preoperative nursing assessment is a valuable tool for perioperative nurses. This article describes the pediatric history, approach to pediatric physical examination, methods of examination, and a system-by-system review of important considerations for the pediatric patient. | ['Adolescent', 'Child', 'Child, Preschool', 'Humans', 'Infant', 'Medical History Taking', 'Nursing Assessment', 'Physical Examination', 'Preoperative Care'] | 7,780,423 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.510'], ['N04.590.233.508.480'], ['E01.370.600'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Usability of the revised NIOSH lifting equation. | Following the revision of the 1981 National Institute for Occupational Safety and Health (NIOSH) lifting equation, research needs related to the new equation were outlined. Aside from epidemiological studies, the need to evaluate the usability of the 1991 NIOSH equation in realistic work environments was expressed. Thi... | ['Guideline Adherence', 'Humans', 'Inservice Training', 'Lifting', 'National Institute for Occupational Safety and Health, U.S.', 'Occupational Health', 'Reproducibility of Results', 'Task Performance and Analysis', 'United States'] | 12,487,684 | [['N04.761.337', 'N05.715.360.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.574'], ['G01.374.669'], ['I01.409.418.750.600.650.200.520', 'N03.540.348.500.500.600.650.225.520'], ['N01.400.525'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['F02.784.412.846', 'F02.784.... | ['Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Managing care: utilization review in action at two capitated medical groups. | Despite widespread concern about denials of coverage by managed care organizations, little empirical information exists on the profile and outcomes of utilization review decisions. This study examines the outcomes of nearly a half-million coverage requests in two large medical groups that contract with health plans to ... | ['California', 'Group Practice, Prepaid', 'Humans', 'Insurance Claim Review', 'Insurance, Health, Reimbursement', 'Managed Care Programs', 'United States', 'Utilization Review'] | 14,527,261 | [['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['N04.452.758.244.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.215'], ['N03.219.521.576.343.480', 'N03.219.521.710'], ['N03.219.521.576.343.800', 'N04.590.374.410'], ['Z01.107.567.875'], ['N04.761.879', 'N05.700.900']] | ['Geographicals [Z]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Fixed-interval behavior maintained by conditioned reinforcement. | The key-pecking of a pigeon was reinforced with grain on an 18-min second-order schedule. During the 18 min, a key peck which completed a 3-min fixed interval produced a stimulus of 0.5-sec duration. The first 3-min fixed interval completed after 18 min resulted in primary reinforcement. Behavior characteristic of fixe... | ['Animals', 'Behavior, Animal', 'Columbidae', 'Conditioning, Psychological', 'Male', 'Reinforcement Schedule', 'Reinforcement, Psychology'] | 6,056,800 | [['B01.050'], ['F01.145.113'], ['B01.050.150.900.248.165.150'], ['F02.463.425.179'], ['F02.463.425.770.644'], ['F02.463.425.770']] | ['Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relationship between Obstructive Sleep Apnea and Self-assessed Oral Health Status: An Internet Survey. | The purpose of this study based on a cross-sectional internet survey was to investigate the relationship between risk of obstructive sleep apnea (OSA) and self-assessed oral health status. The participants, who comprised individuals registered with an online research company, were required to complete a self-reported q... | ['Adult', 'Age Factors', 'Aged', 'Body Mass Index', 'Cross-Sectional Studies', 'Dental Health Surveys', 'Diagnostic Self Evaluation', 'Female', 'Gingival Diseases', 'Gingival Hemorrhage', 'Halitosis', 'Humans', 'Hypertension', 'Internet', 'Male', 'Middle Aged', 'Oral Health', 'Sex Factors', 'Sleep Apnea, Obstructive', ... | 27,665,695 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.438.300', 'E06.208', 'N05.715.360.300.800.438.300'... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Liquid crystal forehead temperature strips. A clinical appraisal. | We recently compared two brands of liquid crystal temperature strips, designed for application to the forehead, Clinitemp and Fever Scan, with recently calibrated rectal and oral glass thermometers in 134 children. The Clinitemp identified as febrile nine (28%) of 33 children who had fever verified by a glass thermomet... | ['Adolescent', 'Child', 'Child, Preschool', 'Crystallization', 'Fever', 'Humans', 'Infant', 'Thermometers'] | 7,064,942 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.196.300', 'G02.171'], ['C23.888.119.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E07.900']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[A familial outbreak of verotoxin-producing Escherichia coli O103:H2 infection in which a calf was the suspected infectious source]. | A familial outbreak of Verotoxin-producing Escherichia coli (VTEC) infection occurred in July 1996 in AKITA prefecture. Four VTEC strains harboring VT-1 and eaeA genes were isolated from three patients and a calf, breeding farm for which was located as close as 4 meters from the house where the patients lived in. All o... | ['Animals', 'Bacterial Toxins', 'Cattle', 'Child', 'Child, Preschool', 'Disease Outbreaks', 'Enterotoxins', 'Escherichia coli', 'Escherichia coli Infections', 'Family', 'Humans', 'Infant', 'Japan', 'Male', 'Serotyping', 'Shiga Toxin 1', 'Zoonoses'] | 9,745,220 | [['B01.050'], ['D23.946.123'], ['B01.050.150.900.649.313.500.380.271'], ['M01.060.406'], ['M01.060.406.448'], ['N06.850.290'], ['D23.946.330'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of pH on the speciation and solubility of divalent metals in human and bovine milks. | Computer models estimated the ligand speciation and solubility of calcium, magnesium, zinc, and copper over a pH range for low molecular weight fractions characteristic of either human or bovine milks. Above pH 4 calcium is the only metal predicted to precipitate. Most of the remaining soluble calcium, magnesium, and z... | ['Animals', 'Biological Availability', 'Calcium', 'Caseins', 'Cattle', 'Humans', 'Hydrogen-Ion Concentration', 'Magnesium', 'Metals', 'Milk', 'Milk, Human', 'Solubility', 'Spectrophotometry, Atomic', 'Ultrafiltration', 'Zinc'] | 3,701,327 | [['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['B01.050.150.900.649.313.500.380.271'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D01... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Tobacco-Free Cigarette Smoke Exposure Induces Anxiety and Panic-Related Behaviours in Male Wistar Rats. | Smokers, who generally present with lung damage, are more anxious than non-smokers and have an associated augmented risk of panic. Considering that lung damage signals specific neural pathways that are related to affective responses, the aim of the present study was to evaluate the influence of pulmonary injury on anxi... | ['Animals', 'Anxiety', 'Behavior, Animal', 'Male', 'Maze Learning', 'Panic', 'Rats', 'Rats, Wistar', 'Tobacco Smoke Pollution'] | 29,563,583 | [['B01.050'], ['F01.470.132'], ['F01.145.113'], ['F02.463.425.874.500'], ['F01.470.361.585'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D20.633.937.680', 'N06.850.460.100.555']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Interactions of cantharidin-like inhibitors with human protein phosphatase-5 in a Mg2+ | The serine/threonine protein phosphatase type 5 (PP5) is a promising target for designing new antitumor drugs. This enzyme is a member of the PPP phosphatases gene family, which catalyzes a dephosphorylation reaction: a regulatory process in the signal transduction pathway that controls various biological processes. Th... | ['Cantharidin', 'Catalytic Domain', 'Cations, Divalent', 'Drug Design', 'Enzyme Inhibitors', 'Humans', 'Magnesium', 'Molecular Dynamics Simulation', 'Nuclear Proteins', 'Phosphoprotein Phosphatases'] | 30,280,322 | [['D03.633.100.127.125'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['D01.248.497.300.333'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.505.519.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['E05.599.595... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Endovascular treatment of cerebral aneurysms with selectively detachable platinum coils]. | In 14 patients (eight men, six women; mean age 58 [31-72] years) with intracranial aneurysm (basilar artery in nine, anterior branches in five) the aneurysm was occluded by electrically detachable platinum coils, advanced into the aneurysm introduced via a percutaneously introduced catheter system, under local anaesthe... | ['Acute Disease', 'Adult', 'Aged', 'Anesthesia, Local', 'Aneurysm, Ruptured', 'Cerebral Angiography', 'Embolization, Therapeutic', 'Evaluation Studies as Topic', 'Female', 'Fluoroscopy', 'Follow-Up Studies', 'Humans', 'Intracranial Aneurysm', 'Male', 'Middle Aged', 'Platinum', 'Subarachnoid Hemorrhage', 'Time Factors',... | 7,768,161 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['E03.155.086.231'], ['C14.907.055.185'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['E02.520.360', 'E02.926.500'], ['E05.337', 'N05.715.360.335'], ['... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison between mainly mucosa-supported and combined mucosa-implant-supported mandibular overdentures. | The purpose of this study is to compare mainly mucosa-supported and combined mucosa-implant-supported complete mandibular overdentures. Ten completely edentulous patients received 20 press-fit dental implants at the canine regions of the mandible. Each patient received 2 implants, which were left submerged and unloaded... | ['Alveolar Bone Loss', 'Dental Implantation', 'Dental Implantation, Endosseous', 'Dental Plaque', 'Dental Prosthesis, Implant-Supported', 'Dental Restoration Failure', 'Dental Stress Analysis', 'Denture Design', 'Denture Retention', 'Denture, Overlay', 'Female', 'Gingivitis', 'Humans', 'Jaw, Edentulous', 'Magnetics', '... | 15,592,001 | [['C05.116.264.150', 'C07.465.714.354.500'], ['E04.545.550.280', 'E04.650.230', 'E06.645.550.280', 'E06.780.314'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['C07.793.208.377'], ['E06.780.346.706', 'E07.695.190.185'], ['E06.323.400', 'E06.780.346.725'], ['E06.308'], ['E06.780... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Determination of the full-genome sequence of hepatitis E virus (HEV) SAAS-FX17 and use as a reference to identify putative HEV genotype 4 virulence determinants. | BACKGROUND: Four major genotypes of hepatitis E virus (HEV), the causative agent of hepatitis E, have so far been recognized. While genotypes 3 and 4 are both zoonotic, the disease symptoms caused by the latter tend to be more severe. To examine if specific nucleotide/amino acid variations between genotypes 3 and 4 pla... | ["3' Untranslated Regions", "5' Untranslated Regions", 'Animals', 'Base Sequence', 'Genome, Viral', 'Genotype', 'Hepatitis E virus', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Open Reading Frames', 'Phylogeny', 'RNA, Viral', 'Sequence Alignment', 'Sequence Analysis, DNA', 'Swine', 'Virulence'] | 23,134,633 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['D13.444.735.544.875.885', 'D13.444.735.790.878.885', 'G05.360.340.024.220.880.885', 'G05.360.340.024.340.137.910.885'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Chronic corticosterone administration dose-dependently modulates Abeta(1-42)- and NMDA-induced neurodegeneration in rat magnocellular nucleus basalis. | The impact of glucocorticoids on beta-amyloid(1-42) (Abeta(1-42)) and NMDA-induced neurodegeneration was investigated in vivo. Abeta(1-42) or NMDA was injected into the cholinergic magnocellular nucleus basalis in adrenalectomized (ADX) rats, ADX rats supplemented with 25%, 100%, 2x100% corticosterone pellets, or sham-... | ['Amyloid beta-Peptides', 'Animals', 'Basal Nucleus of Meynert', 'Corticosterone', 'Dose-Response Relationship, Drug', 'Excitatory Amino Acid Agonists', 'Male', 'N-Methylaspartate', 'Nerve Degeneration', 'Neuroprotective Agents', 'Peptide Fragments', 'Rats', 'Rats, Wistar', 'Time Factors'] | 10,844,576 | [['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['A08.186.211.200.885.287.249.880.100'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['D12.125.067.500.400', 'D12.125.119.170.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Time from symptom onset to treatment and outcomes after thrombolytic therapy. GUSTO-1 Investigators. | OBJECTIVES: This study sought to examine the relations among patient characteristics, time to thrombolysis and outcomes in the international GUSTO-I trial.BACKGROUND: Studies have shown better left ventricular function and decreased infarct size as well as increased survival with earlier thrombolysis, but the relative ... | ['Aged', 'Female', 'Fibrinolytic Agents', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Plasminogen Activators', 'Streptokinase', 'Thrombolytic Therapy', 'Time Factors', 'Tissue Plasminogen Activator', 'Treatment Outcome'] | 8,636,549 | [['M01.060.116.100'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['D08.811.277.656.300.760.635', 'D08.811.277.656.959.350.635', 'D12.776... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy. | AIM: This study aimed to evaluate the effects of monotherapy with valproate or oxcarbazepine on the linear growth of children with idiopathic epilepsy.METHODS: Antiepileptic treatment with valproate or oxcarbazepine was initiated in 76 patients. These were evaluated at baseline and at 6 and 18 months after commencement... | ['Adolescent', 'Anticonvulsants', 'Body Height', 'Carbamazepine', 'Child', 'Child, Preschool', 'Epilepsy', 'Female', 'Ghrelin', 'Humans', 'Insulin-Like Growth Factor Binding Protein 3', 'Insulin-Like Growth Factor I', 'Male', 'Oxcarbazepine', 'Puberty', 'Valproic Acid'] | 22,630,163 | [['M01.060.057'], ['D27.505.954.427.080'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['D03.633.300.240.127'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.140.490'], ['D06.472.699.301', 'D12.644.548.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
HHV-6-DNAemia related to CMV-DNAemia after liver transplantation. | In addition to cytomegalovirus (CMV), activation of other betaherpesviruses, especially human herpesvirus 6 (HHV-6), has been reported in liver transplant patients. The purpose of this study was to investigate the posttransplant HHV-6-DNAemia in relation to CMV-DNAemia in liver transplant patients. Thirty-one adult liv... | ['Adult', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'DNA, Viral', 'Follow-Up Studies', 'Herpesvirus 6, Human', 'Humans', 'Liver Transplantation', 'Polymerase Chain Reaction', 'Postoperative Complications', 'Postoperative Period', 'Roseolovirus Infections', 'Time Factors', 'Transplantation, Homologous'] | 15,848,678 | [['M01.060.116'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['D13.444.308.568'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B04.280.382.150.750.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Abnormal responses to ingested substances in murine systemic lupus erythematosus: apparent effect of a casein-free diet on the development of systemic lupus erythematosus in NZB/W mice. | To assess the development of oral tolerance to casein in NZB/W female mice, they must be bred and raised on a casein free diet. We examined the specific immune responses of the mice to the long term experimental feeding of casein. Twelve of fifteen casein free mice were still alive at 10 months of age, although by this... | ['Animals', 'Antibodies, Antinuclear', 'Caseins', 'DNA', 'Female', 'Food Hypersensitivity', 'Lupus Erythematosus, Systemic', 'Lupus Nephritis', 'Mice', 'Mice, Inbred NZB'] | 3,497,268 | [['B01.050'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['D13.444.308'], ['C20.543.480.370'], ['C17.300.480', 'C20.111.590'], ['C12.777.419.570.363.680', 'C13.351.968.419.570.363.680', 'C17.300.480.680', 'C2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Polymorphisms at IL28B gene as predictors of viral relapse in genotype 4 Egyptian hepatitis C patients. | Chronic HCV is one of the commonest causes of chronic liver disease worldwide with about 15% of population infected in Egypt. Certain single nucleotide polymorphisms (SNPs) lying near the IL28B gene were found to affect the spontaneous clearance as well as treatment outcome of HCV. To examine the association between di... | ['Adult', 'Antiviral Agents', 'Cross-Sectional Studies', 'Drug Therapy, Combination', 'Egypt', 'Female', 'Genotype', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Interferons', 'Interleukins', 'Male', 'Middle Aged', 'Polyethylene Glycols', 'Polymorphism, Single Nucleotide',... | 26,280,154 | [['M01.060.116'], ['D27.505.954.122.388'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E02.319.310'], ['Z01.058.266.317'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Factors associated with stigma among caregivers of patients with bipolar disorder in the STEP-BD study. | OBJECTIVE: Little is known about the factors contributing to mental illness stigma among caregivers of people with bipolar disorder.METHODS: A total of 500 caregivers of patients participating in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study were interviewed in a cross-sectional desi... | ['Adolescent', 'Adult', 'Aged', 'Bipolar Disorder', 'Caregivers', 'Cost of Illness', 'Cross-Sectional Studies', 'Depression', 'Female', 'Health Promotion', 'Humans', 'Male', 'Middle Aged', 'Psychology', 'Severity of Illness Index', 'Social Support', 'Stereotyping'] | 17,215,411 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F03.084.500'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['I02.233... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Familial risks for nerve, nerve root and plexus disorders in siblings based on hospitalisations in Sweden. | BACKGROUND: Nerve, nerve root and plexus disorders are common diseases, but little is known about familial clustering in these diseases. This is, to our knowledge, the first systematic family study carried out on these diseases.METHODS: Familial risks for siblings who were hospitalised for nerve, nerve root and plexus ... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Cohort Studies', 'Cranial Nerve Diseases', 'Female', 'Genetic Predisposition to Disease', 'Hospitalization', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Peripheral Nervous System Diseases', 'Risk Assessment', 'Risk Factors', 'Siblings', 'S... | 17,183,020 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C10.292'], ['C23.550.291.687.500', 'G05.380.355'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Investigation into the lignin decomposition mechanism by analysis of the pyrolysis product of Pinus radiata. | Lignin pyrolysis chemistry was investigated via the analysis of the products obtained from the fast pyrolysis of a pine wood at different temperatures. Methoxy phenols, such as guaiacols and eugenols, were produced mainly at 375 and 475°C, while non-methoxy phenols, such as alkyl phenols and pyrocatechols were dominant... | ['Hot Temperature', 'Lignin', 'Phenols', 'Pinus', 'Wood'] | 27,501,034 | [['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D05.750.078.562.180.515', 'D05.750.078.687', 'D20.538', 'D25.720.099.687', 'J01.637.051.720.099.687'], ['D02.455.426.559.389.657'], ['B01.650.940.800.575.912.625.875.777'], ['A18.4... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Computing with synthetic protocells. | In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The architecture of a computing machine relies on these generic and composable building blocks, computation units, that can be used in multiple instances to perform complex boo... | ['Algorithms', 'Artificial Cells', 'Computer Simulation', 'Electrons', 'Enzymes', 'Oxidative Phosphorylation', 'Photosynthesis', 'Synthetic Biology', 'Thermodynamics'] | 25,969,126 | [['G17.035', 'L01.224.050'], ['J01.637.051.479.258', 'J01.637.087.500.254'], ['L01.224.160'], ['G01.249.335', 'G01.358.500.750'], ['D08.811'], ['G02.111.665.550', 'G03.295.631', 'G03.796.550'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['H01.158.273.9... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. | We tested whether cyclooxygenase 2 (COX-2) expression and unacetylated COX-1 in newly formed platelets might contribute to persistent thromboxane (TX) biosynthesis in aspirin-treated essential thrombocythemia (ET). Forty-one patients on chronic aspirin (100 mg/day) and 24 healthy subjects were studied. Platelet COX-2 e... | ['Adult', 'Aspirin', 'Cyclooxygenase 1', 'Cyclooxygenase 2', 'Cyclooxygenase Inhibitors', 'Drug Therapy, Combination', 'Etoricoxib', 'Female', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Platelet Aggregation Inhibitors', 'Pyridines', 'Sulfones', 'Thrombocythemia, Essential', 'Thromboxane A2', 'Thromboxane... | 19,887,674 | [['M01.060.116'], ['D02.455.426.559.389.657.410.595.176'], ['D08.811.600.720.500'], ['D08.811.600.720.750'], ['D27.505.519.389.310', 'D27.505.696.663.850.014.040.500.500', 'D27.505.954.158.030.500', 'D27.505.954.329.030.500'], ['E02.319.310'], ['D02.886.590.444', 'D03.383.725.354'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
National emergency response programs for dental health care professionals. | BACKGROUND: Members of the established public health systems and medical community must understand that, in medical surge events, members of the dental profession and other non-traditional disaster health care personnel are an additional source of assistance in response activities.METHODS: The authors relied on hands-o... | ['Civil Defense', 'Dental Auxiliaries', 'Dentists', 'Disaster Medicine', 'Disaster Planning', 'Disasters', 'Education, Dental', 'Emergency Medical Services', 'Emergency Medicine', 'Humans', 'Life Support Care', 'Rescue Work', 'Terrorism', 'United States', 'Volunteers'] | 18,682,621 | [['I01.451.227'], ['M01.526.485.067.105', 'N02.360.067.105'], ['M01.526.485.330', 'N02.360.330'], ['H02.403.230'], ['N06.230.100.035'], ['N06.230.100'], ['I02.358.274'], ['N02.421.297'], ['H02.403.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.440', 'N02.421.585.440'], ['N06.230.100.350'], ['I01.198.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of prolonged intermittent thyrotropin-releasing hormone administration to fetal and neonatal rats. | Fetal and neonatal rats received daily subcutaneous injections of 10 microgram thyrotropin-releasing hormone (TRH) until 7 or 14 days postnatally. At 70 days the pups were challenged with 1 microgram TRH intravenously via an indwelling jugular cannula. Basal serum thyroxine, triiodothyronine, and thyroid-stimulating ho... | ['Animals', 'Animals, Newborn', 'Female', 'Fetus', 'Pregnancy', 'Rats', 'Thyrotropin', 'Thyrotropin-Releasing Hormone', 'Time Factors'] | 106,940 | [['B01.050'], ['B01.050.050.282'], ['A16.378'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['D06.472.699.631.525.883', 'D12.644.548.691.525.883'], ['D06.472.699.327.740.880', 'D12.644.400.400.740.880', 'D12.644.456.837', 'D12.644.548.365.740.880', 'D12.776.631.650.405.740.880', 'D12.776.631.650.8... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[An attempt to use ofloxacin in patients with mucoviscidosis]. | The literature data and the data of the authors on the pathogenesis and pathogenetic and etiotropic therapy of mucoviscidosis are presented. The use of ofloxacin as an antibacterial agent in the complex treatment of mucoviscidosis is considered expedient. The drug was administered intravenously in a dose of 400 mg twic... | ['Administration, Oral', 'Anti-Infective Agents', 'Cystic Fibrosis', 'Humans', 'Klebsiella', 'Microbial Sensitivity Tests', 'Neutrophils', 'Ofloxacin', 'Prognosis', 'Pseudomonas aeruginosa', 'Respiratory Burst', 'Sputum', 'Staphylococcus aureus'] | 9,005,785 | [['E02.319.267.100'], ['D27.505.954.122'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.450.425.425', 'B03.660.250.150.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Galangin, a dietary flavonol inhibits tumor initiation during experimental pulmonary tumorigenesis by modulating xenobiotic enzymes and antioxidant status. | The aim of present study was to elucidate anti-initiating efficacy of galangin against benzo(a)pyrene (B(a)P)-induced lung carcinogenesis in male Swiss albino mice. Therefore, the activities of xenobiotic metabolic enzymes such as phase I and II were examined in lung as well as liver tissues (to compare the effects bet... | ['Animals', 'Antioxidants', 'Carcinogenesis', 'Flavonoids', 'Lung Neoplasms', 'Male', 'Mice', 'Xenobiotics'] | 24,497,035 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C04.697.098', 'C23.550.727.098'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['D26.969']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fired ceramic inlays: a 6-year follow up. | OBJECTIVES: The aim of this study was to evaluate feldspathic ceramic inlays luted with dual-cured resin composite or glass polyalkenoate (ionomer) cement (GIC) during a 6-year follow-up.METHODS: One-hundred and eighteen Class II fired feldspathic ceramic inlays were placed in 50 patients. In each patient half of the i... | ['Adult', 'Aged', 'Composite Resins', 'Dental Porcelain', 'Dental Restoration Failure', 'Female', 'Glass Ionomer Cements', 'Humans', 'Inlays', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Resin Cements'] | 9,594,473 | [['M01.060.116'], ['M01.060.116.100'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['D25.339.376', 'J01.637.051.339.376', 'J01.637.153.377'], ['E06.323.400', 'E06.780.346.725'], ['D25.339.291.402', 'J01.637.051.339.291.402'], ['B01.050.150... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Death from inappropriate therapy for Lyme disease. | A 30-year-old woman died as a result of a large Candida parapsilosis septic thrombus located on the tip of a Groshong catheter. The catheter had been in place for 28 months for administration of a 27 month course of intravenous cefotaxime for an unsubstantiated diagnosis of chronic Lyme disease. | ['Adult', 'Candidiasis', 'Catheterization, Central Venous', 'Catheters, Indwelling', 'Cefotaxime', 'Cephalosporins', 'Diagnostic Errors', 'Fatal Outcome', 'Female', 'Humans', 'Iatrogenic Disease', 'Lyme Disease', 'Thrombosis'] | 11,049,799 | [['M01.060.116'], ['C01.150.703.160'], ['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['E07.132.500'], ['D02.065.589.099.249.190.190', 'D02.886.665.074.190.190', 'D03.633.100.300.249.190.190'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['E01.354', 'N02.421.450.280'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Use of a First Large-Sized Coil Versus Conventional Coils for Embolization of Cerebral Aneurysms: Effects on Packing Density, Coil Length, and Durable Occlusion. | OBJECTIVE: To investigate effects of using a large-sized coil first on embolizing cerebral aneurysms compared with conventional coils.MATERIALS AND METHODS: Forty-six patients with 51 saccular intracranial aneurysms who underwent embolization with a large-sized coil first were enrolled as the large-sized coil group. Th... | ['Aged', 'China', 'Cohort Studies', 'Embolization, Therapeutic', 'Female', 'Follow-Up Studies', 'Humans', 'Intracranial Aneurysm', 'Male', 'Middle Aged', 'Treatment Outcome'] | 30,946,999 | [['M01.060.116.100'], ['Z01.252.474.164'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.520.360', 'E02.926.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.600'... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hamartoma of the spleen: a manfestation of tuberous sclerosis. | An unusual case of tuberous sclerosis is presented in which splenomegaly and abdominal pain predominated. The clinical manifestations of the disease are discussed, and the generalized hamartonmatous nature of the diseases is emphasized. | ['Adolescent', 'Blood Cell Count', 'Blood Platelets', 'Hamartoma', 'Humans', 'Male', 'Radiography', 'Splenic Neoplasms', 'Tuberous Sclerosis'] | 1,166,974 | [['M01.060.057'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['A11.118.188', 'A15.145.229.188'], ['C04.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700'], ['C04.588.842', 'C15.604.744.680'], ['C0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inverse laminoplasty for the treatment of lumbar spinal stenosis. | STUDY DESIGN: Fifteen patients with lumbar spinal stenosis were treated by a new technique, inverse laminoplasty, and the results were evaluated clinically and radiologically.OBJECTIVE: To present the advantages of inverse laminoplasty over laminectomy for the treatment of lumbar spinal stenosis.SUMMARY AND BACKGROUND ... | ['Adolescent', 'Adult', 'Bone Plates', 'Disability Evaluation', 'Female', 'Follow-Up Studies', 'Humans', 'Laminectomy', 'Lumbar Vertebrae', 'Lumbosacral Region', 'Male', 'Medical Illustration', 'Middle Aged', 'Neurosurgical Procedures', 'Orthopedic Procedures', 'Prospective Studies', 'Spinal Canal', 'Spinal Stenosis', ... | 12,131,752 | [['M01.060.057'], ['M01.060.116'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E01.370.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.718.563', 'E04.188.400', 'E04.525.450', 'E04.55... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 |
Gastric dilatation-volvulus in the dog with histological evidence of preexisting inflammatory bowel disease: a retrospective study of 23 cases. | The gastric dilatation-volvulus (GDV) syndrome in the dog is considered to be multifactorial. The medical records of 42 dogs treated for GDV between 1990 and 1994 were reviewed in an effort to evaluate the correlation between GDV and preexisting gastrointestinal disease. Twenty-three cases fit the inclusion criteria of... | ['Animals', 'Biopsy', 'Dog Diseases', 'Dogs', 'Edema', 'Female', 'Gastric Dilatation', 'Inflammatory Bowel Diseases', 'Intestinal Obstruction', 'Jejunum', 'Male', 'Neutrophils', 'Retrospective Studies', 'Syndrome'] | 8,784,718 | [['B01.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C23.888.277'], ['C06.405.748.300'], ['C06.405.205.731', 'C06.405.469.432'], ['C06.405.469.531'], ['A03.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Basal local cerebral glucose utilization is not altered after behavioral sensitization to quinpirole. | Sensitization to psychostimulants results in a behavioral response of a greater magnitude than that produced by a given single dose. Previously, we have shown that sensitization to the D(2)/D(3) dopamine receptor agonist quinpirole produces alterations in quinpirole-stimulated local cerebral glucose utilization (LCGU) ... | ['Animals', 'Autoradiography', 'Behavior, Animal', 'Binding, Competitive', 'Central Nervous System Stimulants', 'Cerebral Cortex', 'Deoxyglucose', 'Dopamine', 'Dopamine Agonists', 'Energy Metabolism', 'Glucose', 'Male', 'Motor Activity', 'Neurons', 'Quinpirole', 'Rats', 'Rats, Long-Evans', 'Receptors, Dopamine D2', 'Se... | 17,997,222 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['F01.145.113'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D27.505.696.282', 'D27.505.954.427.220'], ['A08.186.211.200.885.287.500'], ['D09.254.229'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342']... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hepatoblastoma. | Hepatoblastoma is a rare hepatic tumor generally presenting during the first three years of life as an enlarging abdominal mass. Other symptoms are nonspecific; however, it may be associated with hemihypertrophy, virilization, and osteoporosis. The serum bilirubin infrequently is elevated, but up to 2/3's will have ele... | ['Carcinoma, Hepatocellular', 'Child, Preschool', 'Humans', 'Infant', 'Liver Neoplasms', 'Male', 'Radiography', 'Radionuclide Imaging'] | 3,028,688 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E01.370.350.700'], ['E01.370.350.710', 'E01.370.384.730']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of nitric oxide on detrusor relaxation. | PURPOSE: Recently we (1994) reported the photo-induced adequate nitric oxide (PIANO) system, in which an NO- or NO2-carrying molecule which has been photoactivated to release NO, could be exploited to investigate the role of NO in various smooth muscle functions. This study was designed to characterize the effect of ni... | ['Animals', 'Arginine', 'Cyclic GMP', 'In Vitro Techniques', 'Isometric Contraction', 'Male', 'Methylene Blue', 'Muscle, Smooth', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitroarginine', 'Pyrogallol', 'Radioimmunoassay', 'Rats', 'Rats, Sprague-Dawley', 'Streptozocin', 'Ultraviolet Rays', 'Urinary Bladder'] | 8,618,342 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['E05.481'], ['G11.427.494.472'], ['D02.886.369.517', 'D03.633.300.783.517'], ['A02.633.570', 'A10.690.467'], ['D01.339.387', 'D01.625.550.500', 'D01... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression. | The -330 IL2 gene promoter polymorphism has been associated with multiple sclerosis (MS) [J. Neuroimmunol. 119 (2001) 101], but the basis underlying this association remains unknown to date. In the present work, we have found that IL2 promoter-luciferase constructs, transfected in Jurkat cell line, showed twofold highe... | ['Alleles', 'Cell Line, Tumor', 'Disease Susceptibility', 'Gene Expression', 'Gene Expression Regulation', 'Genetic Predisposition to Disease', 'Humans', 'Interleukin-2', 'Luciferases', 'Lymphocytes', 'Molecular Sequence Data', 'Multiple Sclerosis', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length', ... | 14,975,604 | [['G05.360.340.024.340.030'], ['A11.251.210.190', 'A11.251.860.180'], ['C23.550.291.687', 'G07.100.250'], ['G05.297'], ['G05.308'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Preparation of (001)-oriented Pb(Zr,Ti)O3 thin films and their piezoelectric applications. | Preparation of (001)-oriented Pb(Zr,Ti)O(3) (PZT) thin films and their applications to a sensor and actuators were investigated. These thin films, which have a composition close to the morphotropic phase boundary, were epitaxially grown on (100)MgO single-crystal substrates by RF magnetron sputtering. These (001)-orien... | ['Electrochemistry', 'Equipment Design', 'Equipment Failure Analysis', 'Lead', 'Materials Testing', 'Membranes, Artificial', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Titanium', 'Transducers', 'Ultrasonography', 'Zirconium'] | 18,276,534 | [['H01.181.529.307'], ['E05.320'], ['E05.325.192'], ['D01.268.556.435', 'D01.552.544.435'], ['E05.570'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.... | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
[Severe rectal bleeding after transrectal US-guided prostate biopsy. Case report]. | CASE: The Authors report their experience about a case of severe rectal bleeding after transrectal ultrasound-guided prostate biopsy.INTERVENTION: After correct and sure diagnosis, the patient was submitted to resolutive endoscopic haemostatic treatment (failure of haemostatic mechanical manoeuvres, emergency colonscop... | ['Biopsy, Needle', 'Gastrointestinal Hemorrhage', 'Humans', 'Male', 'Middle Aged', 'Prostate', 'Rectal Diseases', 'Rectum', 'Severity of Illness Index', 'Ultrasonography'] | 17,064,492 | [['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A05.360.444.575', 'A10.33... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The peopling of Greenland: further insights from the analysis of genetic diversity using autosomal and X-chromosomal markers. | The peopling of Greenland has a complex history shaped by population migrations, isolation and genetic drift. The Greenlanders present a genetic heritage with components of European and Inuit groups; previous studies using uniparentally inherited markers in Greenlanders have reported evidence of a sex-biased, admixed g... | ['Chromosomes, Human, X', 'Genetic Markers', 'Genetic Variation', 'Greenland', 'Human Migration', 'Humans', 'Inuits'] | 24,801,759 | [['A11.284.187.520.300.325.680', 'A11.284.187.865.982.500', 'G05.360.162.520.300.325.680', 'G05.360.162.865.982.500'], ['D23.101.387', 'G05.695.450'], ['G05.365'], ['Z01.107.567.403', 'Z01.542.816.124.500', 'Z01.639.400'], ['I01.240.600.525', 'N01.224.625.525', 'N06.850.505.400.700.525'], ['B01.050.150.900.649.313.988.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Gonadal function in boys with steroid-responsive nephrotic syndrome treated with cyclophosphamide for short periods. | Semen analysis was undertaken in 19 men over the age of 18 years who had been treated during childhood for steroid-responsive nephrotic syndrome with a single course of cyclophosphamide 3 mg/kg bodyweight for 8 weeks. A further 4 men who received two such courses of treatment were also studied. Plasma total androgens a... | ['Adolescent', 'Adult', 'Child', 'Cyclophosphamide', 'Follow-Up Studies', 'Humans', 'Libido', 'Male', 'Nephrotic Syndrome', 'Risk', 'Sperm Motility', 'Spermatogenesis', 'Testis'] | 6,112,527 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.739.794.511'], ['C12.777.419.630.643', 'C13.351.968.419.630.643'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site. | DBI (diazepam-binding inhibitor) is a putative neuromodulatory peptide isolated from rat brain that acts on gamma-aminobutyric acid-benzodiazepine-Cl- ionophore receptor complex inducing beta-carboline-like effects. We used a cDNA probe complementary to DBI mRNA and a specific antibody for rat DBI to study in rat brain... | ['Animals', 'Brain', 'Chlordiazepoxide', 'DNA', 'Diazepam', 'Diazepam Binding Inhibitor', 'Kinetics', 'Male', 'Neuropeptides', 'Nucleic Acid Hybridization', 'RNA, Messenger', 'Rats', 'Rats, Inbred Strains', 'Receptors, GABA-A'] | 3,029,781 | [['B01.050'], ['A08.186.211'], ['D03.633.100.079.080.150'], ['D13.444.308'], ['D03.633.100.079.080.070.216'], ['D12.644.136'], ['G01.374.661', 'G02.111.490'], ['D12.644.400', 'D12.776.631.650'], ['E05.393.661', 'G02.111.611'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760',... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dabrafenib Therapy in 30 Patients with Melanoma Metastatic to the Brain: a Single-centre Controlled Retrospective Study in Hungary. | Dabrafenib is a potent BRAF inhibitor, which showed intracranial tumor activity. The purpose of our retrospective analysis was to evaluate the efficacy of dabrafenib for patients with melanoma brain metastasis (BM). We studied 30 BRAF mutant melanoma patients with BM, who received dabrafenib after local control of the ... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Brain Neoplasms', 'Disease-Free Survival', 'Female', 'Humans', 'Hungary', 'Imidazoles', 'Male', 'Melanoma', 'Middle Aged', 'Oximes', 'Retrospective Studies', 'Treatment Outcome', 'Young Adult'] | 28,567,600 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Brain Structural Networks in Mouse Exposed to Chronic Maternal Undernutrition. | Brain structural connectivity is known to be altered in cases of intrauterine growth restriction and premature birth, although the specific effect of maternal nutritional restriction, a common burden in human populations, has not been assessed yet. Here we analyze the effects of maternal undernutrition during pregnancy... | ['Animals', 'Brain', 'Female', 'Fetal Growth Retardation', 'Fetal Nutrition Disorders', 'Magnetic Resonance Imaging', 'Mice', 'Mice, Inbred C57BL', 'Neural Pathways', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Prenatal Nutritional Physiological Phenomena'] | 29,631,020 | [['B01.050'], ['A08.186.211'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['C13.703.277.677', 'C18.654.521.625'], ['E01.370.350.825.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A08.612'], ['G08.686.784.769'], ['C13.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of donor and host age on the regeneration and blood flow of splenic transplants. | After splenectomy there is an increased risk of fatal overwhelming postsplenectomy sepsis, especially in children. If all alternatives to splenectomy fail, autotransplantation of splenic fragments is indicated. These fragments regenerate after a necrotic phase to small splenic nodules. Regulatory factors governing the ... | ['Age Factors', 'Animals', 'Male', 'Rats', 'Rats, Inbred Lew', 'Regeneration', 'Spleen', 'Tissue Donors'] | 3,263,490 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.280', 'B01.050.150.900.649.313.992.635.505.700.400.280'], ['G16.762'], ['A10.549.700', 'A15.382.520.604.700'], ['M01.898']] | ['Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. | OBJECTIVE: Thiol oxidative stress leads to macrophage dysfunction and cell injury, and has been implicated in the development of atherosclerotic lesions. We investigated if strengthening the glutathione-dependent antioxidant system in macrophages by overexpressing glutathione reductase (GR) decreases the severity of at... | ['Adenoviridae', 'Animals', 'Atherosclerosis', 'Bone Marrow Cells', 'Bone Marrow Transplantation', 'Cells, Cultured', 'Cytosol', 'Dietary Fats', 'Disease Models, Animal', 'Female', 'Genetic Therapy', 'Genetic Vectors', 'Glutathione', 'Glutathione Reductase', 'Humans', 'LDL-Receptor Related Proteins', 'Lipoproteins, LDL... | 17,363,688 | [['B04.280.030'], ['B01.050'], ['C14.907.137.126.307'], ['A11.148', 'A15.378.316'], ['E02.095.147.725.040', 'E04.936.580.040'], ['A11.251'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.095.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A web service for enabling medical image retrieval integrated into a social medical image sharing platform. | Content-based visual image access is in the process from a research domain towards real applications. So far, most image retrieval applications have been in one specialized domain such as lung CTs as diagnosis aid or for classification of general images based on anatomic region, modality, and view. This article describ... | ['Diagnostic Imaging', 'Information Storage and Retrieval', 'Internet', 'Radiology Information Systems', 'User-Computer Interface'] | 20,841,889 | [['E01.370.350'], ['L01.313.500.750.280', 'L01.470'], ['L01.224.230.110.500'], ['N04.452.515.825'], ['L01.224.900.910']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction. | STUDY QUESTION: Does phthalate exposure from prescription drugs affect semen quality?SUMMARY ANSWER: Exposure to phthalate-containing drugs is associated with poor semen quality.WHAT IS KNOWN ALREADY: Phthalates and their metabolites have been shown to disrupt the hormone signalling in animal studies. One study has sho... | ['Adult', 'Denmark', 'Environmental Exposure', 'Fertilization in Vitro', 'Humans', 'Male', 'Phthalic Acids', 'Prescription Drugs', 'Registries', 'Semen Analysis', 'Sperm Count', 'Spermatozoa'] | 29,425,332 | [['M01.060.116'], ['Z01.542.816.124'], ['N06.850.460.350'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.223.805'], ['D26.670'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['E01.370.225.992', 'E05.200.992'], ['E01.370.2... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells. | BACKGROUND AND AIMS: Acyl-CoA synthetase 5 (ACS5) has been reported to be associated with the development of various cancers, but the role of it in colorectal cancer (CRC) is not well understood. The present study aimed to explore the potential role of ACS5 in the development and progression of CRC.METHODS: ACS5 expres... | ['Cadherins', 'Caspase 3', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Coenzyme A Ligases', 'Colorectal Neoplasms', 'Disease Progression', 'Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown Techniques', 'HT29 Cells', 'Humans', 'Hyaluronan Receptors', 'Inhibitor of Apoptosis Pro... | 28,808,653 | [['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.2... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Injection of day 2 embryo culture supernatant into the uterine cavity did not improve the pregnancy rate of day 3 embryo transfer in patients who underwent in vitro fertilization-embryo transfer: a randomized clinical trial. | OBJECTIVE: To evaluate the effectiveness of uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer in patients who are undergoing in vitro fertilization-embryo transfer.DESIGN: Randomized controlled trial.SETTING: A reproductive medical centre.PATIENT(S): A total of 90 infertile women... | ['Adult', 'Algorithms', 'Culture Media, Conditioned', 'Embryo Culture Techniques', 'Embryo Implantation', 'Embryo Transfer', 'Female', 'Fertilization in Vitro', 'Humans', 'Infertility, Female', 'Injections', 'Male', 'Pregnancy', 'Pregnancy Rate', 'Time Factors', 'Uterus', 'Young Adult'] | 19,439,284 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['D27.720.470.305.250', 'E07.206.250'], ['E05.481.500.468'], ['G08.686.784.170.104.500'], ['E02.875.800.500', 'E05.820.800.500'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['E02.319.267.530'], ['G08.686... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Ovarian cancer--a comparison between CT diagnosis and serum tumor markers]. | In 40 patients undergoing pre-treatment for an ovarian tumor, a CT scan of the pelvis and measurements of their CA 125, CA 19-9, IAP (immunosuppressive acidic antigen), and TPA (tissue polypeptide antigen were performed. The specificity and sensitivity of the CT diagnosis was found to be better than any of other tumor ... | ['Antigens, Neoplasm', 'Antigens, Tumor-Associated, Carbohydrate', 'Biomarkers, Tumor', 'Female', 'Humans', 'Neoplasm Proteins', 'Ovarian Neoplasms', 'Peptides', 'Tissue Polypeptide Antigen', 'Tomography, X-Ray Computed'] | 3,422,324 | [['D23.050.285'], ['D23.050.285.050', 'D23.050.550.325', 'D23.101.140.075'], ['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.624'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['D12.644'], ['D12.644.875', 'D23.050.285.840', 'D23.10... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinoma. | BACKGROUND/AIMS: Ribonucleotide reductase M1 (RRM1) is a key molecule for gemcitabine resistance. This study evaluated the immunohistochemical expression of RRM1 in resected specimens of intrahepatic cholangiocarcinoma (ICC) and investigated the efficacy of gemcitabine-based neoadjuvant chemotherapy in relation to RRM1... | ['Adult', 'Aged', 'Bile Duct Neoplasms', 'Bile Ducts, Intrahepatic', 'Biomarkers, Tumor', 'Chi-Square Distribution', 'Cholangiocarcinoma', 'Female', 'Humans', 'Immunoenzyme Techniques', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoadjuvant Therapy', 'Ribonucleotide Reductases', 'Survival Rate', 'Tomography, X-Ray Comp... | 21,940,346 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['A03.159.183.158', 'A03.620.150'], ['D23.101.140'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C04.557.470.200.025.450'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands. | We encountered two cases of low malignant mucoepidermoid carcinoma with scanty cellular atypism which originated in the parotid or submandibular gland and was characterized by marked fibrosis and eosinophilic infiltration within tumor tissue despite the predominance of the squamous component. Here we report these two c... | ['Adult', 'Biomarkers, Tumor', 'Carcinoma, Mucoepidermoid', 'Diagnosis, Differential', 'Eosinophilia', 'Female', 'Fibrosis', 'Humans', 'Immunohistochemistry', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Parotid Neoplasms', 'Sclerosis', 'Submandibular Gland Neoplasms'] | 12,049,340 | [['M01.060.116'], ['D23.101.140'], ['C04.557.470.200.025.340', 'C04.557.470.590.340'], ['E01.171'], ['C15.378.553.231'], ['C23.550.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Round-headed spermatozoa in semen specimens from fertile and subfertile men. | OBJECTIVE: To investigate the frequency of round-headed, or acrosomeless, spermatozoa, determine the percentage and evaluate the possible correlation with other semen parameters.STUDY DESIGN: Semen specimens from 114 subfertile men aged 24-53 years (mean +/- SD 33.3 +/- 6.3) and from 60 fertile men aged 24-44 years (33... | ['Acrosome', 'Adult', 'Case-Control Studies', 'Humans', 'Infertility, Male', 'Male', 'Middle Aged', 'Semen', 'Severity of Illness Index', 'Sperm Count', 'Sperm Injections, Intracytoplasmic', 'Sperm Midpiece', 'Sperm Motility', 'Sperm-Ovum Interactions'] | 12,092,019 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['M01.060.116.630'], ['A12.200.732'], ['E05.318.308.980.438.47... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Primary rhabdomyosarcoma of the cerebellum--a light, electron microscopic, and immunohistochemical study. | A primary cerebellar rhabdomyosarcoma (RMS) in a six and a half year old boy is reported. Microscopy of the surgical material revealed lobules of closely packed cells with a high mitotic rate, pleomorphic hyperchromatic nuclei and scant cytoplasm. At their periphery, the lobules merged with rounded cells with similar n... | ['Cerebellar Neoplasms', 'Child', 'Humans', 'Immunochemistry', 'Male', 'Microscopy, Electron', 'Rhabdomyosarcoma'] | 6,737,010 | [['C04.588.614.250.195.411.211', 'C10.228.140.211.500.200', 'C10.228.140.252.200', 'C10.551.240.250.400.300'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.486', 'H01.181.122.605', 'H02.403.044.500'], ['E01.370.350.515.402', 'E05.595.402'], ['C04.557.450.590.550.660', 'C04.557.450.795... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
A medical geographical anniversary. | It is now 200 years since L. L. Finke wrote his treatise on a global medical geography, Versuch einer allgemeinen medicinisch-praktischen Geographie. It was both the most extensive book in substantive content, and the most detailed in conceptual discussion on medical geography written to that point. Although it is one ... | ['Geography', 'Germany', 'History, 18th Century', 'Humans', 'Manuscripts, Medical as Topic'] | 8,211,285 | [['H01.277.500'], ['Z01.542.315'], ['K01.400.504.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.178.682.608.526']] | ['Disciplines and Occupations [H]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes. | We report the identification of a human cDNA encoding a 25 kDa protein of relevant evolutionary and lymphoid interest (PRELI). PRELI was cloned by screening a B lymphocyte-specific cDNA library with a probe generated by mRNA differential display. PRELI amino acid sequence is 85% similar to the avian px19 protein, expre... | ['Adult', 'Amino Acid Sequence', 'Animals', 'B-Lymphocytes', 'Blotting, Northern', 'Cell Line', 'DNA, Complementary', 'Evolution, Molecular', 'Fetus', 'Germinal Center', 'Humans', 'Mitochondrial Proteins', 'Molecular Sequence Data', 'Proteins', 'Quail', 'RNA, Messenger', 'Sequence Alignment', 'Viscera'] | 10,784,606 | [['M01.060.116'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A11.251.210'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
A placebo-controlled trial of isoprinosine in patients with multiple sclerosis. | Isoprinosine was used under double-blind, randomised, and placebo-controlled conditions in 52 patients with relapsing/remitting or progressive multiple sclerosis. All patients received pulsed treatment with methylprednisolone. There was no significant effect of treatment on clinical disability or the accumulation of MR... | ['Administration, Oral', 'Adult', 'Analysis of Variance', 'Double-Blind Method', 'Female', 'Humans', 'Inosine Pranobex', 'Magnetic Resonance Imaging', 'Male', 'Multiple Sclerosis', 'Recurrence', 'Treatment Outcome'] | 7,510,330 | [['E02.319.267.100'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.199.092.450', 'D02.092.146.113.092.450', 'D03.633.100.759.590.616.450... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. | Extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) by DNA damage is a major cause of caspase-independent cell death in ischemia and inflammation. Here we show that NAD(+) depletion and mitochondrial permeability transition (MPT) are sequential and necessary steps in PARP-1-mediated cell death. Cultured mous... | ['Animals', 'Apoptosis', 'Apoptosis Inducing Factor', 'Astrocytes', 'Flavoproteins', 'Intracellular Membranes', 'Membrane Potentials', 'Membrane Proteins', 'Mice', 'Mice, Knockout', 'Mitochondria', 'NAD', 'Permeability', 'Poly(ADP-ribose) Polymerases', 'Protein Transport'] | 14,960,594 | [['B01.050'], ['G04.146.954.035'], ['D08.811.682.608.047', 'D12.644.360.075.311', 'D12.776.157.687.063', 'D12.776.331.161', 'D12.776.476.075.311', 'D12.776.660.720.063'], ['A08.637.200', 'A11.650.200'], ['D12.776.331'], ['A11.284.149.450', 'A11.284.835.514'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Quality parameters of cryoprecipitates from stored blood preservation]. | The investigations of a series of 281 cryoprecipitates produced from blood stored at 10 degrees C for 12-18 hours resulted in equal values as compared with those preparations from a control group of 53 preparations which had been prepared from blood maximally stored for 4 hours. Thus, international experiences could be... | ['Blood Preservation', 'Factor VIII', 'Freezing', 'Humans', 'Time Factors'] | 2,435,639 | [['E02.792.833.230', 'E05.760.833.230'], ['D12.776.124.125.350', 'D12.776.811.286', 'D23.119.350'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland. | Systemic lipopolysaccharide (LPS) administration induces an innate immune response and stimulates the hypothalamic-pituitary-adrenal axis. We studied Angiotensin II AT(1) receptor participation in the LPS effects with focus on the pituitary gland. LPS (50 microg/kg, i.p.) enhanced, 3h after administration, gene express... | ['Adrenocorticotropic Hormone', 'Analysis of Variance', 'Angiotensin II Type 1 Receptor Blockers', 'Animals', 'Autoradiography', 'Benzimidazoles', 'Corticosterone', 'Cytokines', 'Dinoprostone', 'Enzyme-Linked Immunosorbent Assay', 'Hypothalamo-Hypophyseal System', 'In Situ Hybridization', 'Inflammation', 'Lipopolysacch... | 19,427,376 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.519.162.500'], ['B01.050'], ['E01.370.225.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers. | A novel group of racemic isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate isomers [(+/-)-12-14] were prepared using a modified Hantzsch reaction that involved the condensation of nitroacetone with isopropyl 3-aminocrotonate and 2-, 3-, or 4-pyridinecarboxaldehyde. Determination of their in v... | ['3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester', 'Animals', 'Calcium Channel Agonists', 'Calcium Channel Blockers', 'Carboxylic Acids', 'Guinea Pigs', 'Heart', 'Heart Ventricles', 'Hypertension', 'In Vitro Techniques', 'Male', 'Membrane Potentials', 'Muscle Co... | 7,543,577 | [['D03.383.725.203.600', 'D03.383.725.547.900'], ['B01.050'], ['D27.505.519.562.124', 'D27.505.696.260.250', 'D27.505.954.411.793.205'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D02.241'], ['B01.050.150.900.649.313.992.550'], ['A07.541'], ['A07.541.560'], ['C14.907.489'], ['E05.481'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Is accredited social health activists' basic oral health knowledge appropriate in educating rural Indian population? | INTRODUCTION: Accredited social health activists (ASHAs) are the grassroot level health activists in the community who are involved in health education and community mobilization toward utilizing the health services.MATERIALS AND METHODS: A descriptive cross-sectional study was carried out to assess the oral health kno... | ['Accreditation', 'Adult', 'Community Health Workers', 'Cross-Sectional Studies', 'Educational Status', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'India', 'Male', 'Oral Health', 'Rural Health Services', 'Rural Population', 'Workforce'] | 29,072,211 | [['N03.706.110.070', 'N05.700.200.100'], ['M01.060.116'], ['M01.526.485.067.080', 'N02.360.067.080'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N01.824.196'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['N01.400.53... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Disease and immunity in the pre-Spanish Philippines. | It is generally asserted that Filipino populations did not suffer the same demographic collapse that followed Spanish conquest in the Americas because they had previously acquired immunity to Old World diseases through trading contacts with Asia. This assertion is examined by trying to establish which diseases were pre... | ['China', 'Colonialism', 'Disease Outbreaks', 'Disease Vectors', 'Emigration and Immigration', 'Environmental Microbiology', 'History, 16th Century', 'History, 17th Century', 'History, 18th Century', 'History, 19th Century', 'Humans', 'Immunity, Innate', 'Infections', 'Japan', 'Philippines', 'Population Dynamics', 'Top... | 10,405,020 | [['Z01.252.474.164'], ['I01.696.116'], ['N06.850.290'], ['N06.850.335.188', 'N06.850.520.203.375'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['H01.158.273.540.274', 'N06.850.425'], ['K01.400.475.750'], ['K01.400.504.750'], ['K01.400.504.875'], ['K01.400.504.937'], ['B01.050.150.900... | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Effects of dietary eritadenine on the liver microsomal Delta6-desaturase activity and its mRNA in rats. | Eritadenine, a hypocholesterolemic factor of Lentinus edodes mushroom, has a wide range of effects on lipid metabolism such as an increase in the liver microsomal phosphatidylethanolamine (PE) concentration, a decrease in the liver microsomal Delta6-desaturase activity, and an alteration of the fatty acid and molecular... | ['Adenine', 'Animals', 'Dietary Supplements', 'Hypercholesterolemia', 'Lipids', 'Male', 'Microsomes, Liver', 'Phospholipids', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Stearoyl-CoA Desaturase', 'Time Factors'] | 12,843,651 | [['D03.633.100.759.138'], ['B01.050'], ['G07.203.300.456', 'J02.500.456'], ['C18.452.584.500.500.396'], ['D10'], ['A11.284.835.540.541'], ['D10.570.755'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D08.811.682.690.708.392.625'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Identification of runs of homozygosity affecting female fertility and milk production traits in Finnish Ayrshire cattle. | Inbreeding gives rise to continuous lengths of homozygous genotypes called runs of homozygosity (ROH) that occur when identical haplotypes are inherited from both parents. ROHs are enriched for deleterious recessive alleles and can therefore be linked to inbreeding depression, defined as decreased phenotypic performanc... | ['Animals', 'Cattle', 'Female', 'Fertility', 'Genotype', 'Homozygote', 'Milk'] | 32,123,255 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G08.686.210'], ['G05.380'], ['G05.380.554'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. | BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain. Data from many epidemiological studies in different levels of malaria endemicity and in areas... | ['Animals', 'Antimalarials', 'Artemisinins', 'Drug Resistance', 'Drug Therapy, Combination', 'Health Policy', 'Humans', 'Lactones', 'Malaria', 'Models, Theoretical', 'Plasmodium', 'Thailand'] | 18,976,503 | [['B01.050'], ['D27.505.954.122.250.100.085'], ['D01.248.497.158.685.750.212', 'D01.339.431.374.212', 'D01.650.550.750.200', 'D02.389.338.055', 'D02.455.849.765.211'], ['G07.690.773.984'], ['E02.319.310'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
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